Journal of the Korean Society of Visualization (한국가시화정보학회지)

The Korean Society of Visualization (한국가시화정보학회)
권호 표지
DOI QR코드

DOI QR Code

On-demand Acoustofluidic Droplet Generation with Tunable Droplet Volume

음향미세유체역학적 미세액적 생성 및 부피 제어

  • Kim, Woo Hyuk (School of Mechanical Engineering, Chonnam National University) ;
  • Park, Jinsoo (School of Mechanical Engineering, Chonnam National University)
  • Received : 2020.07.24
  • Accepted : 2020.08.26
  • Published : 2020.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

On-demand droplet generation with tunable droplet volume is fundamental in many droplet microfluidic applications. In this work, we propose an acoustofluidic method to produce water-in-oil droplets with prescribed volume in an on-demand manner. Surface acoustic waves produced from a slanted interdigital transducer are coupled with parallel laminar streams of dispersed and continuous phase fluids. Acoustic radiation force acting on the fluid interface enable generation of droplets in a microfluidic chip. We expect that the proposed acoustofluidic droplet generation method will serve as a promising tool for on-demand droplet generation with on-chip droplet volume control.

Keywords

References

  1. Schneider, T., Kreutz, J., and Chiu, D. T., 2013, "The potential impact of droplet microfluidics in biology," Anal Chem, Vol. 85(7), pp. 3476-3482. https://doi.org/10.1021/ac400257c
  2. Sesen, M., Alan, T., and Neild, A, 2017, "Droplet control technologies for microfluidic high throughput screening (${\mu}$HTS)," Lab Chip, Vol. 17(15), pp. 2372-2394. https://doi.org/10.1039/C7LC00005G
  3. Mashaghi, S., Abbaspourrad, A., Weitz, D.A., and van Oijen, A.M., 2016, "Droplet microfluidics: A tool for biology, chemistry and nanotechnology," TrAC Trends in Analytical Chemistry, Vol. 82, pp. 118-125. https://doi.org/10.1016/j.trac.2016.05.019
  4. Zhu, P. and Wang, L., 2016, "Passive and active droplet generation with microfluidics: a review," Lab Chip, Vol. 17(1), pp. 34-75. https://doi.org/10.1039/C6LC01018K
  5. He, M., Kuo, J. S., and Chiu, D. T., 2005, "Electro-generation of single femtoliter- and picoliter-volume aqueous droplets in microfluidic systems," Applied Physics Letters, Vol. 87(3), pp. 031916-1-031916-3. https://doi.org/10.1063/1.1997280
  6. Park, S. Y., Wu, T. H., Chen, Y., Teitell, M. A., and Chiou, P. Y., 2011, "High-speed droplet generation on demand driven by pulse laser-induced cavitation," Lab Chip, Vol. 11(7), pp. 1010-1012. https://doi.org/10.1039/c0lc00555j
  7. Collins, D. J., Alan, T., Helmerson, K., and Neild, A., 2013, "Surface acoustic waves for on-demand production of picoliter droplets and particle encapsulation," Lab Chip, Vol. 13(16), pp. 3225-3231. https://doi.org/10.1039/c3lc50372k
  8. Park, J., Jung, J. H., Park, K., Destgeer, G., Ahmed, H., Ahmad, R., and Sung, H. J., 2018, "On-demand acoustic droplet splitting and steering in a disposable microfluidic chip," Lab Chip, Vol. 18(3), pp. 422-432. https://doi.org/10.1039/C7LC01083D
  9. Park, J., Destgeer, G., Kim, H., Cho, Y., and Sung, H. J., 2018, "In-droplet microparticle washing and enrichment using surface acoustic wave-driven acoustic radiation force," Lab Chip, Vol. 18(19), pp. 2936-2945. https://doi.org/10.1039/C8LC00733K
  10. Park, J., Jung, J. H., Destgeer, G., Ahmed, H., Park, K., and Sung, H. J., 2017, "Acoustothermal tweezer for droplet sorting in a disposable microfluidic chip," Lab Chip, Vol. 17(6), pp. 1031-1040. https://doi.org/10.1039/C6LC01405D