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Determination of Possible Prognostic Indicators in Dogs with Pyometra

  • Lee, Jun-Am (Wellcare Veterinary Hospital) ;
  • Kim, Ill-Hwa (Laboratory of Veterinary Theriogenology, Veterinary Teaching Hospital and College of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Tae-Ku (Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation) ;
  • Hwang, Dae-Youn (Department of Biomaterials Science, Pusan National University) ;
  • Kang, Hyun-Gu (Laboratory of Veterinary Theriogenology, Veterinary Teaching Hospital and College of Veterinary Medicine, Chungbuk National University)
  • Received : 2020.08.11
  • Accepted : 2020.08.18
  • Published : 2020.08.31

Abstract

The aims of this study were to analyze canine pyometra cases at Veterinary Medical Center of Chungbuk National University, and to identify prognostic factors of canine pyometra at the stage of diagnosis. Records of cases about intact female dogs presented to Veterinary Medical Center from 2005 to 2019 were used for analysis. A total of 147 intact female dogs with canine pyometra were analyzed from outpatients' caseload. Median outbreak age was 9.6 years (range, 8 months to 17 years). The highest prevalence of pyometra over 14 years was observed in Maltese (22.4%, n = 33). Urologic disorders (21.8%, n = 32) including acute renal failure and cystic calculi were the most frequently observed concurrent disorders in dogs with pyometra. In other cases of pyometra, tumor (15.0%, n = 29), cardiovascular disorders (15.0%, n = 22) and systemic disorders (10.9%, n = 16) were accompanied with pyometra. The concentrations of BUN, creatinine and glucose were higher than reference range in cases of poor prognosis. According to the binominal logistic regression analysis, prognosis in pyometra was related to abdominal distension (p = 0.036), urologic disorder (p = 0.016), gastrointestinal disorder (p = 0.001), and serum level of blood urea nitrogen (BUN) (p = 0.045). This study describes that prognosis of canine pyometra can be predicted at the stage of diagnosis by abdominal distension, urologic disorder, gastrointestinal disorder, and serum level of BUN.

Keywords

References

  1. Biddle D, Macintire DK. Obstetrical emergencies. Clin Tech Small Anim Pract 2000; 15: 88-93. https://doi.org/10.1053/svms.2000.6803
  2. Bigliardi E, Parmigiani E, Cavirani S, Luppi A, Bonati L, Corradi A. Ultrasonography and cystic hyperplasia-pyometra complex in the bitch. Reprod Domest Anim 2004; 39: 136-140. https://doi.org/10.1111/j.1439-0531.2004.00489.x
  3. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644-1655. https://doi.org/10.1378/chest.101.6.1644
  4. Borresen B. Pyometra in the dog. II.-A pathophysiological investigation. II. Anamnestic, clinical and reproductive aspects. Nord Vet Med 1979; 31: 251-257.
  5. Coggan JA, Melville PA, de Oliveira CM, Faustino M, Moreno AM, Benites NR. Microbiological and histopathological aspects of canine pyometra. Braz J Microbiol 2008; 39: 477-483. https://doi.org/10.1590/S1517-838220080003000012
  6. Conti-Patara A, de Araujo Caldeira J, de Mattos-Junior E, de Carvalho Hda S, Reinoldes A, Pedron BG, Patara M, Francisco Talib MS, Faustino M, de Oliveira CM, Cortopassi SR. Changes in tissue perfusion parameters in dogs with severe sepsis/septic shock in response to goal-directed hemodynamic optimization at admission to ICU and the relation to outcome. J Vet Emerg Crit Care 2012; 22: 409-418. https://doi.org/10.1111/j.1476-4431.2012.00769.x
  7. de Schepper J, van der Stock J, Capiau E. The characteristic pattern of aspartate aminotransferase and alanine aminotransferase in the bitch with the cystic hyperplasia-pyometra complex: effect of medical or surgical treatment. Vet Res Commun 1987; 11: 65-75. https://doi.org/10.1007/BF00361327
  8. Dow C. The cystic hyperplasia-pyometra complex in the bitch. J Comp Pathol 1959; 69: 237.
  9. Egenvall A, Hagman R, Bonnett BN, Hedhammar A, Olson P, Lagerstedt AS. Breed risk of pyometra in insured dogs in Sweden. J Vet Intern Med 2001; 15: 530-538. https://doi.org/10.1892/0891-6640(2001)015<0530:BROPII>2.3.CO;2
  10. Faldyna M, Laznicka A, Toman M. Immunosuppression in bitches with pyometra. J Small Anim Pract 2001; 42: 5-10. https://doi.org/10.1111/j.1748-5827.2001.tb01976.x
  11. Fayrer-Hosken RA, Mahaffey M, Miller-Liebl D, Caudle AB. Early diagnosis of canine pyometra using ultrasonography. Vet Radiol 1991; 32: 287-289. https://doi.org/10.1111/j.1740-8261.1991.tb00125.x
  12. Fransson B, Lagerstedt AS, Hellmen E, Jonsson P. Bacteriological findings, blood chemistry profile and plasma endotoxin levels in bitches with pyometra or other uterine diseases. Zentralbl Veterinarmed A. 1997; 44: 417-426.
  13. Fukuda S. Incidence of pyometra in colony-raised beagle dogs. Exp Anim 2001; 50: 325-329. https://doi.org/10.1538/expanim.50.325
  14. Gibson A, Dean R, Yates D, Stavisky J. A retrospective study of pyometra at five RSPCA hospitals in the UK: 1728 cases from 2006 to 2011. Vet Rec 2013; 173: 396. https://doi.org/10.1136/vr.101514
  15. Gilbert RO, Nothling JO, Oettle EE. A retrospective study of 40 cases of canine pyometra-metritis treated with prostaglandin F-2 alpha and broad-spectrum antibacterial drugs. J Reprod Fertil (Suppl) 1989; 39: 225-229.
  16. Hagman R, Kindahl H, Lagerstedt AS. Pyometra in bitches induces elevated plasma endotoxin and prostaglandin $F_{2{\alpha}}$ metabolite levels. Acta Vet Scand 2006; 47: 55-67. https://doi.org/10.1186/1751-0147-47-55
  17. Hagman R. Diagnostic and prognostic markers for uterine diseases in dogs. Reprod Domest Anim (Suppl 2) 2014; 49: 16-20.
  18. Hagman R, Lagerstedt AS, Hedhammar A, Egenvall A. A breed-matched case-control study of potential risk-factors for canine pyometra. Theriogenology 2011; 75: 1251-1257. https://doi.org/10.1016/j.theriogenology.2010.11.038
  19. Heiene R, Moe L, Molmen G. Calculation of urinary enzyme excretion, with renal structure and function in dogs with pyometra. Res Vet Sci 2001; 70: 129-137. https://doi.org/10.1053/rvsc.2000.0451
  20. Jitpean S, Hagman R, Strom Holst B, Hoglund OV, Pettersson A, Egenvall A. Breed variations in the incidence of pyometra and mammary tumours in Swedish dogs. Reprod Domest Anim (Suppl 6) 2012; 47: 347-350. https://doi.org/10.1111/rda.12103
  21. Kaymaz M, Bastan A, Erunal N, Aslan S, Findik M. The use of laboratory findings in the diagnosis of CEH-pyometra complex in the bitch. Turk J Vet Anim Sci 1999; 23: 127-133.
  22. Krook L, Larsson S, Rooney JR. The interrelationship of diabetes mellitus, obesity, and pyometra in the dog. Am J Vet Res 1960; 21: 120-127.
  23. Nelson RW, Feldman EC, Stabenfeldt GH. Treatment of canine pyometra and endometritis with prostaglandin F2 alpha. J Am Vet Med Assoc 1982; 181: 899-903.
  24. Niskanen M, Thrusfield MV. Associations between age, parity, hormonal therapy and breed, and pyometra in Finnish dogs. Vet Rec 1998; 143: 493-498. https://doi.org/10.1136/vr.143.18.493
  25. Nomura K, Nishida A. Histological variations of canine deciduoma induced in non pregnant horn at different stages of unilateral pregnancy. J Vet Med Sci 1998; 60: 623-626. https://doi.org/10.1292/jvms.60.623
  26. Okano S, Tagawa M, Takase K. Relationship of the blood endotoxin concentration and prognosis in dogs with pyometra. J Vet Med Sci 1998; 60: 1265-1267. https://doi.org/10.1292/jvms.60.1265
  27. Pretzer SD. Clinical presentation of canine pyometra and mucometra: a review. Theriogenology 2008; 70: 359-363. https://doi.org/10.1016/j.theriogenology.2008.04.028
  28. Purvis D, Kirby R. Systemic inflammatory response syndrome: septic shock. Vet Clin North Am Small Anim Pract 1994; 24: 1225-1247.
  29. Rubio A, Boyen F, Tas O, Kitshoff A, Polis I, Van Goethem B, de Rooster H. Bacterial colonization of the ovarian bursa in dogs with clinically suspected pyometra and in controls. Theriogenology 2014; 82: 966-971. https://doi.org/10.1016/j.theriogenology.2014.07.016
  30. Silva E, Leitao S, Ferreira-Dias G, Lopes da Costa L, Mateus L. Prostaglandin synthesis genes are differentially transcripted in normal and pyometra endometria of bitches. Reprod Domest Anim (Suppl 2) 2009; 44: 200-203.
  31. Smith FO. Canine pyometra. Theriogenology 2006; 66: 610-612. https://doi.org/10.1016/j.theriogenology.2006.04.023
  32. Stone EA, Littman MP, Robertson JL, Bovee KC. Renal dysfunction in dogs with pyometra. J Am Vet Med Assoc 1988; 193: 457-464.
  33. Whitehead ML. Risk of pyometra in bitches treated for mismating with low doses of oestradiol benzoate. Vet Rec 2008; 162: 746-749. https://doi.org/10.1136/vr.162.23.746