The Journal of the Society of Stroke on Korean Medicine (대한중풍순환신경학회지)

The Society of Stroke on Korean Medicine (대한중풍순환신경학회)
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Effects of Dangui-jakyak-san on Common Carotid Artery Elasticity in Healthy Subjects ; A Randomized controlled crossover study

당귀작약산이 정상인의 총경동맥 탄력도에 미치는 영향 : 무작위대조군 교차시험

  • Kim, Soohyun (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Seo, Yuna (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Bae, In-hu (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Cho, Ki-Ho (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Moon, Sang-Kwan (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Jung, Woo-Sang (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Kwon, Seungwon (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Jin, Chul (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University)
  • 김수현 (경희대학교 대학원 한방순환.신경내과학교실) ;
  • 서유나 (경희대학교 대학원 한방순환.신경내과학교실) ;
  • 배인후 (경희대학교 대학원 한방순환.신경내과학교실) ;
  • 조기호 (경희대학교 대학원 한방순환.신경내과학교실) ;
  • 문상관 (경희대학교 대학원 한방순환.신경내과학교실) ;
  • 정우상 (경희대학교 대학원 한방순환.신경내과학교실) ;
  • 권승원 (경희대학교 대학원 한방순환.신경내과학교실) ;
  • 진철 (경희대학교 대학원 한방순환.신경내과학교실)
  • Published : 2020.12.01
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Abstract

■ Objectives 당귀작약산 단회 복용으로 정상인의 총경동맥 탄력도에 미치는 영향을 평가하고자 하였다. ■ Methods 본 연구는 정상인 남성을 대상으로 한 전향적 무작위 대조군 교차시험연구다. 모든 대상자들은 임의로 당귀작약산 복용군과 비복용군인 대조군으로 나누어졌다. 1주일 간격으로 총 2회 방문하며, 첫 번째 방문 시에 당귀작약산 복용군은 당귀작약산 1포(2.5g)과 물을 제공받고, 대조군은 물만 제공받아 복용하였다. 두 번째 방문 시 첫 번째 방문과 반대로 당귀작약산을 복용했던 복용군은 물만 제공받고, 물만 복용했던 피험자들은 당귀작약산 1포와 물을 제공받았다. 물은 100 cc로 매번 동일하게 제공되었다. 모든 대상자들은 복용 직전과 복용 2시간, 4시간 후에 총경동맥 탄력도, 혈압, 총경동맥 내막-중막 두께와 맥박수를 측정하였다. ■ Results 총 20명의 정상인 남성이 모집되었으며, 시간에 따라 당귀작약산 복용 후의 총경동맥 탄력도가 대조군에 비하여 유의하게 상승한 것이 확인되었다. 내막-중막 두께, 혈압 및 맥압, 맥박은 유의한 변화가 나타나지 않았다. ■ Conclusion 당귀작약산의 단회 복용으로 총경동맥 탄력도가 즉시 개선되는 것을 확인하였고, 이로써 당귀작약산이 동맥 경직도 완화 및 탄성의 개선에 영향을 미친다는 것을 알 수 있었다.

Keywords

References

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