대한방사성의약품학회지 (Journal of Radiopharmaceuticals and Molecular Probes)

  • 제6권1호
  • /
  • Pages.39-45
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  • 2020
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  • 2384-1583(pISSN)
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  • 2508-3848(eISSN)
대한방사성의약품학회 (Korean Society of Radiopharmaceuticals and Molecular Probes)
권호 표지
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Radiolabeled single-domain antibody for tumor receptor imaging

  • Moon, Yeajin (College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University) ;
  • Lee, Ju Young (College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University) ;
  • Ryoo, Woonseok (College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University) ;
  • Seo, Seung-Yong (College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University)
  • 투고 : 2020.06.15
  • 심사 : 2020.06.26
  • 발행 : 2020.06.30
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초록

Recently, single-domain antibodies (sdAb) are bioengineered for molecular imaging applications. Single-domain antibody, obtained from naturally occurring antibodies in camelid species and cartilaginous fish is the smallest fully functional antigen-binding antibody fragments of heavy-chain. Since their discovery, they have been investigated extensively in clinical therapeutics, monitoring and diagnostics. Their small size is important advantage for high solubility, high stability, fast blood clearance and rapid targeting. This review article summarizes the recent status of this new antibody to visualize, diagnose or inhibit specific targets of cancer.

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