Journal of the Korean Wood Science and Technology

The Korean Society of Wood Science & Technology (한국목재공학회)
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Preparation and Characterization of Cellulose Nanocrystals Reinforced Poly (vinyl alcohol) Based Hydrogels for Drug Delivery System

약물 전달 시스템 적용을 위한 셀룰로오스 나노크리스탈(CNCs) 강화 Poly(vinyl alcohol) 기반 하이드로겔의 제조 및 특성

  • CHO, Hyejung (Division of Wood Chemistry, Department of forest Products, National Institute of Forest Science) ;
  • YOO, Won-Jae (Division of Wood Chemistry, Department of forest Products, National Institute of Forest Science) ;
  • AHN, Jinsoo (Division of Wood Chemistry, Department of forest Products, National Institute of Forest Science) ;
  • CHUN, Sang-Jin (Division of Wood Utilization, Department of forest Products, National Institute of Forest Science) ;
  • LEE, Sun-Young (Forest Biomaterials Research Center, National Institute of Forest Science) ;
  • GWON, Jaegyoung (Division of Wood Chemistry, Department of forest Products, National Institute of Forest Science)
  • Received : 2020.03.06
  • Accepted : 2020.05.04
  • Published : 2020.07.25
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Abstract

Structural property of most hydrogels is soft, resulting in low mechanical performance that limits their usage in the biomedical applications. For overcoming the drawback, cellulose nanocrystals (CNCs) were adopted in this study. Effects of CNCs on characteristics and drug delivery performance of poly (vinyl alcohol) based hydrogels were explored. FT-IR results showed that the fabricated hydrogels had semi-IPN (semi-interpenetrating polymer network) by formation of acetal and aldehyde bridge. Water absorption and swelling ratio decreased with increasing CNCs content, and the hydrogels with CNCs showed better viscoelastic performance than the without CNCs. Also, CNCs mostly improved the ability of the hydrogel to absorb the drug and the sustainability of the drug release. These results demonstrated that incorporating CNCs into the hydrogel systems can be a good alternative to improve drug delivery performance and mechanical property of the hydrogels.

기존 연질 구조의 하이드로겔은 낮은 기계적 강도로 인하여 생의학 분야에서 응용이 제한된다. 본 연구에서는 이러한 단점을 극복하기 위해서 폴리비닐알코올(PVA: poly(vinyl alcohol))기반 하이드로겔에 셀룰로오스 나노크리스탈(CNCs)을 첨가하여 CNCs가 기계적 특성 및 약물전달 효율에 미치는 영향을 확인하였다. 제조된 하이드로겔은 FT-IR 분석으로 아세탈 및 알데히드 결합으로 가교결합된 망상구조(semi-IPN: semi-interpenetrating polymer network)로 합성된 것이 확인되었다. CNCs 함량이 증가될수록 수분 흡수 및 팽윤도가 감소했으며, 점탄성은 증가하였다. 또한 CNCs의 첨가는 약물 로딩량의 증가와 약물 방출량의 지속성을 향상시켰다. 이러한 결과는 CNCs를 하이드로겔에 첨가하는 것이 하이드로겔의 약물전달 효율성 및 기계적 특성을 개선시키는 좋은 대안이 될 수 있음을 보여주었다.

Keywords

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