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http://dx.doi.org/10.5658/WOOD.2020.48.4.431

Preparation and Characterization of Cellulose Nanocrystals Reinforced Poly (vinyl alcohol) Based Hydrogels for Drug Delivery System  

CHO, Hyejung (Division of Wood Chemistry, Department of forest Products, National Institute of Forest Science)
YOO, Won-Jae (Division of Wood Chemistry, Department of forest Products, National Institute of Forest Science)
AHN, Jinsoo (Division of Wood Chemistry, Department of forest Products, National Institute of Forest Science)
CHUN, Sang-Jin (Division of Wood Utilization, Department of forest Products, National Institute of Forest Science)
LEE, Sun-Young (Forest Biomaterials Research Center, National Institute of Forest Science)
GWON, Jaegyoung (Division of Wood Chemistry, Department of forest Products, National Institute of Forest Science)
Publication Information
Journal of the Korean Wood Science and Technology / v.48, no.4, 2020 , pp. 431-449 More about this Journal
Abstract
Structural property of most hydrogels is soft, resulting in low mechanical performance that limits their usage in the biomedical applications. For overcoming the drawback, cellulose nanocrystals (CNCs) were adopted in this study. Effects of CNCs on characteristics and drug delivery performance of poly (vinyl alcohol) based hydrogels were explored. FT-IR results showed that the fabricated hydrogels had semi-IPN (semi-interpenetrating polymer network) by formation of acetal and aldehyde bridge. Water absorption and swelling ratio decreased with increasing CNCs content, and the hydrogels with CNCs showed better viscoelastic performance than the without CNCs. Also, CNCs mostly improved the ability of the hydrogel to absorb the drug and the sustainability of the drug release. These results demonstrated that incorporating CNCs into the hydrogel systems can be a good alternative to improve drug delivery performance and mechanical property of the hydrogels.
Keywords
hydrogels; poly (vinyl alcohol); cellulose nanocrystals (CNCs); drug delivery system;
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1 An, Q., Beh, C., Xiao, H. 2014. Preparation and characterization of thermo-sensitive poly(vinyl alcohol)-based hydrogel as drug carrier. Journal of Applied Polymer Science 131(1): 39720.
2 Cho, H., Baek, K., Jeon, J., Park, S., Suh, D., Park, Y. 2013. Removal characteristics of copper by marine macro-algae-derived chars. Chemical Engineering Journal 217: 205-211.   DOI
3 Gao, Y., Zhu, W., Liu, J., Di, D., Chang, D., Jiang, T., Wang, S. 2015. A geometric pore adsorption model for predicting the drug loading capacity of insoluble drugs in mesoporous carbon. International Journal of Pharmaceutics 485(1): 25-30.   DOI
4 Gwon, J., Cho, H., Chun, S., Lee, S., Wu, Q., Lee, S. 2016. Physiochemical, optical and mechanical properties of poly(lactic acid) nanocomposites filled with toluene diisocyanate grafted cellulose nanocrystals. RSC Advances 6: 9438-9445.   DOI
5 Gwon, J., Cho, H., Lee, D., Choi, D., Lee, S., Wu, Q., Lee, S. 2018. Physicochemical and mechanical properties of polypropylene-cellulose nanocrystal nanocomposites: Effects of manufacturing process and chemical grafting. BioResources 13(1): 1619-1636.
6 Gwon, J., Lee, D., Cho, H., Lee, S. 2018. Preparation and characteristics of cellulose acetate based nanocomposites reinforced with cellulose nanocrystals (CNCs). Journal of the Korean Wood Science and Technology 46(5): 565-576.   DOI
7 Khanjanzadeh, H., Park, B. 2020. Characterization of carboxylated cellulose nanocrystals from recycled fiberboard fibers using ammonium persulfate oxidation. Journal of the Korean Wood Science and Technology 48(2): 231-244.   DOI
8 Hendrawan, H., Khoerunnisa, F., Sonjaya, Y., Putri, A.D. 2019. Poly (vinyl alcohol)/glutaraldehyde/ Premna oblongifolia Merr extract hydrogel for controlled-release and water absorption application. In IOP Conference Series: Materials Science and Engineering; IOP Publishing: Bristol, UK. 012048.
9 Hoare, T.R., Kohane, D.S. 2008. Hydrogels in drug delivery: Progress and challenges. Polymer 49(8): 1993-2007.   DOI
10 Hyon, S., Cha, W., Ikada, Y. 1989. Preparation of transparent poly(vinyl alcohol) hydrogel. Polymer Bulletin 22(2): 119-122.   DOI
11 Kim, H., Jegal, J., Kim, J., Lee, K., Lee, Y. 2003. Enantioselective permeation of ${\alpha}$-amino acid optical isomers through crosslinked sodium alginate membranes. Journal of Applied Polymer Science 89(11): 3046-3051.   DOI
12 Ladet, S., David, L., Domard, A. 2008. Multi-membrane hydrogels. Nature Letters 452: 76-79.   DOI
13 Marin, E., Rojas, J. 2015. Preparation and characterization of crosslinked poly (VINYL) alcohol films with waterproof properties. International Journal of Pharmacy and Pharmaceutical Sciences 7(3): 242-248.
14 Li, J., Mooney, D.J. 2016. Designing hydrogels for controlled drug delivery. Nature Reviews Materials 1: 16071.   DOI
15 Lin, C.C., Metters, A.T. 2006. Hydrogels in controlled release formulations: Network design and mathematical modeling. Advanced Drug Delivery Reviews 58(12): 1379-1408.   DOI
16 Mansur, H.S., Sadahira, C.M., Souza, A.N., Mansur, A.A. 2008. FTIR spectroscopy characterization of poly (vinyl alcohol) hydrogel with different hydrolysis degree and chemically crosslinked with glutaraldehyde. Materials Science and Engineering C 28: 539-548.   DOI
17 Reis, E.F.D., Campos, F.S., Lage, A.P., Leite, R.C., Heneine, L.G., Vasconcelos, W.L., Mansur, H.S. 2006. Synthesis and characterization of poly (vinyl alcohol) hydrogels and hybrids for rMPB70 protein adsorption. Materials Research 9(2): 185-191.   DOI
18 Masruchin, N., Park, B.D., Causin, V. 2015. Influence of sonication treatment on supramolecular cellulose microfibril-based hydrogels induced by ionic interaction. Journal of Industrial and Engineering Chemistry 29(25): 265-272.   DOI
19 McKenzie, M., Betts, D., Suh, A., Bui, K., Kim, L.D., Cho, H. 2015. Hydrogel-based drug delivery systems for poorly water-soluble drugs. Molecules 20(11): 20397-20408.   DOI
20 Pal, K., Banthia, A.K., Majumdar D.K. 2007. Preparation and characterization of polyvinyl alcoholgelatin hydrogel membranes for biomedical applications. An Official Journal of the American Association of Pharmaceutical Scientists 8(1): E142-E146.
21 Valle, L.J.D,. Diaz, A., Puiggali, J. 2017. Hydrogels for biomedical applications: cellulose, chitosan, and protein/peptide derivatives. Gels 3(3): 27.   DOI
22 Rivas, C.J.M., Tarhini, M., Badri, W., Miladi, K., Greige-Gerges, H., Nazari, Q. A., Rodriguez, S.A.G., Roman, R.A., Fessi, H., Elaissari, A. 2017. Nanoprecipitation process: From encapsulation to drug delivery. International Journal of Pharmaceutics 532(1): 66-81.   DOI
23 Tanpichai, S., Oksman, K. 2016. Cross-linked nanocomposite hydrogels based on cellulose nanocrystals and PVA: Mechanical properties and creep recovery. Composites Part A: Applied Science and Manufacturing 88: 226-233.   DOI
24 Thangprasert, A., Tansakul, C., Thuaksubun, N., Meesane, J. 2019. Mimicked hybrid hydrogel based on gelatin/PVA for tissue engineering in subchondral bone interface for osteoarthritis surgery. Materials and Design, 183: 108113.   DOI
25 Mezger, T. 2015. Applied rheology: With Joe flow on rheology road. Anton Paar.
26 Tilak, A., Thakur, R.N., Sharma, R., Verma, M., Gupta, A.K. 2016. Study of adsorption of drug and calculation of Freundlich adsorption isotherm. International Journal of Pharmaceutical and Biological Science Archive 4(4): 01-05.
27 Wang, Q., Mynar, J.L., Yoshida, M., Lee, E., Lee, M., Okuro, K., Kinbara, K., Aida. T. 21, January 2010. High-water-content mouldable hydrogels by mixing clay and a dendritic molecular binder. Nature Letters 463: 339-343.   DOI
28 Xiao, C., Zhou, G. 2003. Synthesis and properties of degradable poly(vinyl alcohol) hydrogel. Polymer Degradation and Stability 81(2): 297-301.   DOI
29 Yeom, C., Lee, K. 1996. Pervaporation separation of water-acetic acid mixtures through poly (vinyl alcohol) membranes crosslinked with glutaraldehyde. Journal of Membrane Science 109(2): 257-265.   DOI
30 Yue, Y., Han, J., Han, G., French, A.D., Qi, Y., Wu, Q. 2016. Cellulose nanofibers reinforced sodium alginate-polyvinyl alcohol hydrogels: Core-shell structure formation and property characterization. Carbohydrate Polymers 147: 155-164.   DOI
31 Zaini, L., Febrianto, F., Wistara, I., Marwanto, N., Maulana, M., Lee, S., Kim, N., 2019. Effect of ammonium persulfate concentration on characteristics of cellulose nanocrystals from oil palm frond. Journal of the Korean Wood Science and Technology 47(5): 597-606.   DOI
32 Zawko, S.A., Truong, Q., Schmidt, C.E. 2008. Drugbinding hydrogels of hyaluronic acid functionalized with ${\beta}$-cyclodextrin. Journal of Biomedical Materials Research Part A 87(4): 1044-1052.   DOI
33 Zhou, Y., Zhang, L., Cheng, Z. 2015. Removal of organic pollutants from aqueous solution using agricultural wastes: A review. Journal of Molecular Liquids 212: 739-762.   DOI