DOI QR코드

DOI QR Code

Splenic myxoid liposarcoma in a dog

개 비장에서 발생한 myxoid liposarcoma 증례 보고

  • Go, Du-Min (Department of Veterinary Pathology and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University) ;
  • Woo, Sang-Ho (Department of Veterinary Pathology and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University) ;
  • Cheon, Doosung (POSTBIO, Inc.) ;
  • Kim, Jun (Howon Animal Medical Center) ;
  • Oh, Ye-In (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Dae-Yong (Department of Veterinary Pathology and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University)
  • 고두민 (서울대학교 수의과대학 수의병리학교실) ;
  • 우상호 (서울대학교 수의과대학 수의병리학교실) ;
  • 천두성 (포스트바이오) ;
  • 김준 (호원동물병원) ;
  • 오예인 (충남대학교 수의과대학 수의내과학교실) ;
  • 김대용 (서울대학교 수의과대학 수의병리학교실)
  • Received : 2019.12.20
  • Accepted : 2020.04.27
  • Published : 2020.06.30

Abstract

A 7-year-old Maltese was presented to a veterinary clinic for a history of anorexia, soft feces, and anemia. During abdominal sonography and computed tomography imaging, splenic mass was suspected. Laparotomy revealed the bloody ascites, and the enlarged spleen containing a large spherical mass. Microscopically, the splenic parenchyma was replaced by neoplastic cells with cytoplasmic vacuolation and abundant myxoid matrix. Cellular vacuolation and myxoid matrix were positive to Oil-Red-O and Alcian-blue stains. The neoplastic cells were positive to vimentin on immunohistochemistry. The case was diagnosed as myxoid liposarcoma. Based on a poor prognosis, the dog was euthanized three weeks after splenectomy.

Keywords

References

  1. Eltweri AM, Gravante G, Read-Jones SL, Rai S, Bowrey DJ, Haynes IG. A case of recurrent mesocolon myxoid liposarcoma and review of the literature. Case Rep Oncol Med 2013;2013:692754. https://doi.org/10.1155/2013/692754
  2. Gower KL, Liptak JM, Culp WT, Bravo L, Powers B, Withrow SJ. Splenic liposarcoma in dogs: 13 cases (2002-2012). J Am Vet Med Assoc 2015;247:1404-1407. https://doi.org/10.2460/javma.247.12.1404
  3. Forlani A, Roccabianca P, Palmieri C, Sarli G, Stefanello D, Santagostino S, Randi C, Avallone G. Pathological characterization of primary splenic myxoid liposarcomas in three dogs. Vet Q 2015;35:181-184. https://doi.org/10.1080/01652176.2015.1049384
  4. Avallone G, Roccabianca P, Crippa L, Lepri E, Brunetti B, Bernardini C, Forni M, Olandese A, Sarli G. Histological classification and immunohistochemical evaluation of MDM2 and CDK4 expression in canine liposarcoma. Vet Pathol 2016;53:773-780. https://doi.org/10.1177/0300985815626573
  5. Valli VE, Bienzle D, Meuten DJ, Linder KE. Tumors of the hemolymphatic system. In: Meuten DJ (ed.). Tumors in Domestic Animals, 5th ed. pp. 314-315, Wiley Blackwell, Ames, 2017.
  6. Hendrick MJ. Mesenchymal tumors of the skin and soft tissues. In: Meuten DJ (ed.). Tumors in Domestic Animals, 5th ed. p. 159, Wiley Blackwell, Ames, 2017.
  7. Spangler WL, Culbertson MR, Kass PH. Primary mesenchymal (nonangiomatous/nonlymphomatous) neoplasms occurring in the canine spleen: anatomic classification, immunohistochemistry, and mitotic activity correlated with patient survival. Vet Pathol 1994;31:37-47. https://doi.org/10.1177/030098589403100105
  8. Weinstein MJ, Carpenter JL, Schunk CJ. Nonangiogenic and nonlymphomatous sarcomas of the canine spleen: 57 cases (1975-1987). J Am Vet Med Assoc 1989;195:784-788.
  9. Dennis MM, McSporran KD, Bacon NJ, Schulman FY, Foster RA, Powers BE. Prognostic factors for cutaneous and subcutaneous soft tissue sarcomas in dogs. Vet Pathol 2011;48:73-84. https://doi.org/10.1177/0300985810388820
  10. Plumlee QD, Hernandez AM, Clark SD, Bascunan A, Davidson J, Mansell J. High-grade myxoid liposarcoma (round cell variant) in a dog. J Comp Pathol 2016;155:305-309. https://doi.org/10.1016/j.jcpa.2016.08.004
  11. Creytens D. A contemporary review of myxoid adipocytic tumors. Semin Diagn Pathol 2019;36:129-141. https://doi.org/10.1053/j.semdp.2019.02.008