Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Extraction Conditions Affect Melanin Inhibitory Activity in Rodgersia podophylla Root

추출조건에 따른 도깨비부채 뿌리의 멜라닌 억제효과

  • Received : 2020.05.26
  • Accepted : 2020.06.24
  • Published : 2020.06.30
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Abstract

Background: The inhibitory effect of Rodgersia podophylla root extract on melanin production has been reported, however, the study on the optimal extraction conditions that increase melanin inhibitory activity has not yet been performed. Methods and Results: In this study, we compared the melanin inhibitory activity of R. podophylla root extract obtained through different preprocessing and extraction methods. The melanin inhibitory activity was examined using Melan-A melanocytes. The results indicated that the inhibitory activity of R. podophylla roots collected in August was higher than that of the roots collected in May and November. Additionally, non-dried R. podophylla roots exhibited higher activity than dried roots, and the stirring extract was more active than the ultrasonic extract. Conclusions: Collection of R. podophylla root when the temperature is high, without drying, and stirring extraction are considered to be the optimal extraction conditions for increased melanin inhibitory effect.

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References

  1. Chin YW and Kim JW. (2006). Three new flavonol glycosides from the aerial parts of Rodgersia podophylla. Chemical and Pharmaceutical Bulletin. 54:234-236. https://doi.org/10.1248/cpb.54.234
  2. Chin YW, Lim SW, Kim YC, Choi SZ, Lee KR and Kim JW. (2004). Hepatoprotective flavonol glycosides from the aerial parts of Rodgersia podophylla. Planta Medica. 70:576-577. https://doi.org/10.1055/s-2004-827163
  3. Chin YW, Park EY, Seo SY, Yoon KD, Ahn MJ, Suh YG, Kim SG and Kim JW. (2006). A novel iNOS and COX-2 inhibitor from the aerial parts of Rodgersia podophylla. Bioorganic and Medicinal Chemistry Letters. 16:4600-4602. https://doi.org/10.1016/j.bmcl.2006.06.009
  4. Choi SY, Kang NJ and Kim HC. (2006). Inhibitory effects of root extracts on melanin biosynthesis in Rodgersia podophylla A. Gray. Korean Journal of Medicinal Crop Science. 14:27-30.
  5. Choi W, Miyamura Y, Wolber R, Smuda C, Reinhold W, Liu H Kolbe L and Hearing VJ. (2010). Regulation of human skin pigmentation in situ by repetitive UV exposure: Molecular characterization of responses to UVA and/or UVB. Journal of Investigative Dermatology. 130:1685-1696. https://doi.org/10.1038/jid.2010.5
  6. Costin GE and Hearing VJ. (2007). Human skin pigmentation: Melanocytes modulate skin color in response to stress. The FASEB Journal. 21:976-994. https://doi.org/10.1096/fj.06-6649rev
  7. Dheeraj M, Shikha C, Parveen K, Vivek V, Kumar D, Deepika T, Khushboo C, Sandeep KM and Dilip S. (2017). Ultraviolet radiations: Skin defense-damage mechanism. Advances in Experimental Medicine and Biology. 996:71-87. https://doi.org/10.1007/978-3-319-56017-5_7
  8. D'Mello SAN, Finlay GJ, Baguley BC and Askarian-Amiri ME. (2016). Signaling pathways in melanogenesis. International Journal of Molecular Sciences. 17:1144. https://www.mdpi.com/1422-0067/17/7/1144 (cited by 2020 March 12). https://doi.org/10.3390/ijms17071144
  9. Inoue Y, Hasegawa S, Yamada T, Date Y, Mizutani H, Nakata S, Matsunaga K and Akamatsu H. (2013). Analysis of the effects of hydroquinone and arbutin on the differentiation of melanocytes. Biological and Pharmaceutical Bulletin. 36:1722-1730. https://doi.org/10.1248/bpb.b13-00206
  10. Kim H, Kim JD, Son HJ, Park GH, Eo HJ and Jeong JB. (2019). Anti-cancer activity of the leave extracts of Rodgersia podophylla through ${\beta}$-catenin proteasomal degradation in human cancer cells. Korean Journal of Plant Resources. 32:442-447.
  11. Kim HN, Kim JD, Park SB, Son HJ, Park GH, Eo HJ, Kim HS and Jeong JB. (2020). Anti-inflammatory activity of the extracts from Rodgersia podophylla leaves through activation of Nrf2/HO-1 pathway, and inhibition of NF-${\kappa}$B and MAPKs pathway in mouse macrophage cells. Inflammation Research. 69:233-244. https://doi.org/10.1007/s00011-019-01311-2
  12. Kim NY and Lee HY. (2015). Effect of antioxidant and skin whitening of ethanol extracts from ultrasonic pretreated abeliophyllum distichum nakai. The Korean Journal of Medicinal Crop Science. 23:155-160. https://doi.org/10.7783/KJMCS.2015.23.2.155
  13. Kim YS, Lim DO, Oh HK and Shin HT. (2002). Vascular plants of Taebaksan, Hambaesan, Geumdaebong(peak) and maebongsan in the Baekkdudaegan. Korean Journal of Environment and Ecology. 15:293-318.
  14. Kong YH, Lee PJ and Choi SY. (2007). Action of Rodgersia podophylla root extracts on melanin biosynthesis in skin. Korean Journal of Medicinal Crop Science. 15:434-436.
  15. Lai X, Wichers HJ, Soler-Lopez M and Dijkstra BW. (2018). Structure and function of human tyrosinase and tyrosinaserelated proteins. Chemistry-A European Journal. 24:47-55. https://doi.org/10.1002/chem.201704410
  16. Miyamura Y, Coelho SG, Wolber R, Miller SA, Wakamatsu K, Zmudzka BZ, Ito S, Smuda C, Passeron T, Choi W, Batzer J, Yamaguchi Y, Beer JZ and Hearing VJ. (2006). Regulation of human skin pigmentation and responses to ultraviolet radiation. Pigment Cell Research. 20:2-13. https://doi.org/10.1111/j.1600-0749.2006.00358.x
  17. No JK, Soung DY, Kim YJ, Shim KH, Jun YS, Rhee SH, Yokozawa T and Chung HY. (1999). Inhibition of tyrosinase by green tea components. Life Sciences. 65:241-246.
  18. Pillaiyar T, Manickam M and Jung SH. (2017). Recent development of signaling pathways inhibitors of melanogenesis. Cell Signalling. 40:99-115. https://doi.org/10.1016/j.cellsig.2017.09.004
  19. Pyo SJ, Lee YJ, Kang DG, Son HJ, Park GH, Park JY and Sohn HY. (2020). Antimicrobial, antioxidant, and anti-diabetic activities of Rodgersia podophylla. Journal of Life Science. 30:298-303. https://doi.org/10.5352/JLS.2020.30.3.298
  20. Saeedi M, Eslamifar M and Khezri K. (2019). Kojic acid applications in cosmetic and pharmaceutical preparations. Biomedicine & Pharmacotherapy. 110:582-593. https://doi.org/10.1016/j.biopha.2018.12.006
  21. Slominski A, Tobin DJ. Shibahara S and Wortsman J. (2004). Melanin pigmentation in mammalian skin and its hormonal regulation. Physiological Reviews. 84:1155-1228. https://doi.org/10.1152/physrev.00044.2003