Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Effects of Lonicera japonica extract on performance, blood biomarkers of inflammation and oxidative stress during perinatal period in dairy cows

  • Zhao, Yiguang (State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences) ;
  • Tang, Zhiwen (State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences) ;
  • Nan, Xuemei (State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences) ;
  • Sun, Fuyu (State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences) ;
  • Jiang, Linshu (Beijing Key Laboratory for Dairy Cow Nutrition, Beijing University of Agriculture) ;
  • Xiong, Benhai (State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences)
  • Received : 2019.05.09
  • Accepted : 2019.09.02
  • Published : 2020.07.01
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Abstract

Objective: An experiment was conducted to evaluate the effects of Lonicera japonica extract (LJE) on milk production, rumen fermentation and blood biomarkers of energy metabolism, inflammation and oxidative stress during the perinatal period of Holstein dairy cows. Methods: Eighteen Holstein dairy cows were used in a complete randomized design experiment with 3 dietary treatments and 6 cows per treatment. All cows received the same basal total mixed ration (TMR) including a prepartal diet (1.35 Mcal of net energy for lactation [NEL]/kg of dry matter [DM], 13.23% crude protein [CP]) from -60 d to calving and a postpartal diet (1.61 Mcal of NEL/kg of DM, 17.39% CP) from calving to 30 days in milk (DIM). The 3 dietary treatments were TMR supplemented with LJE at 0 (control), 1 and 2 g/kg DM, respectively. LJE was offered from 21 d before calving to 30 DIM. Dry matter intake (DMI) and milk production were measured daily after calving. Milk and rumen fluid samples were collected on 29 and 30 d after calving. On -10, 4, 14, and 30 d relative to calving, blood samples were collected to analyze the biomarkers of energy metabolism, inflammation and oxidative stress. Results: Compared with control diet, LJE supplementation at 1 and 2 g/kg DM increased DMI, milk yield and reduced milk somatic cell count. LJE supplementation also decreased the concentrations of blood biomarkers of pro-inflammation (interleukin-1β [IL-1β], IL-6, and haptoglobin), energy metabolism (nonesterified fatty acid and β-hydroxybutyric acid) and oxidative stress (reactive oxygen metabolites), meanwhile increased the total antioxidant capacity and superoxide dismutase concentrations in blood. No differences were observed in rumen pH, volatile fatty acid, and ammonia-N (NH3-N) concentrations between LJE supplemented diets and the control diet. Conclusion: Supplementation with 1 and 2 g LJE/kg DM could increase DMI, improve lactation performance, and enhance anti-inflammatory and antioxidant capacities of dairy cows during perinatal period.

Keywords

References

  1. Goff JP. Major advances in our understanding of nutritional influences on bovine health. J Dairy Sci 2006;89:1292-301. https://doi.org/10.3168/jds.S0022-0302(06)72197-X
  2. Osorio JS, Trevisi E, Ji P, et al. Biomarkers of inflammation, metabolism, and oxidative stress in blood, liver, and milk reveal a better immunometabolic status in peripartal cows supplemented with Smartamine M or MetaSmart. J Dairy Sci 2014;97:7437-50. https://doi.org/10.3168/jds.2013-7679
  3. Castillo C, Hernandez J, Bravo A. Oxidative status during late pregnancy and early lactation in dairy cows. Vet J 2005;169:286-92. https://doi.org/10.1016/j.tvjl.2004.02.001
  4. Loor JJ, Bionaz M, Drackley JK. Systems physiology in dairy cattle: nutritional genomics and beyond. Annu Rev Anim Biosci 2013;1:365-92. https://doi.org/10.1146/annurev-animal- 031412-103728
  5. Sordillo LM, Contreras GA, Aitken SL. Metabolic factors affecting the inflammatory response of periparturient dairy cows. Anim Health Res Rev 2009;10:53-63. https://doi.org/10.1017/S1466252309990016
  6. Graugnard DE, Bionaz M, Trevisi E, et al. Blood immunometabolic indices and polymorphonuclear neutrophil function in peripartum dairy cows are altered by level of dietary energy prepartum. J Dairy Sci 2012;95:1749-58. https://doi.org/10.3168/jds.2011-4579
  7. Guidry AJ, Paape MJ, Pearson RE. Effects of parturition and lactation on blood and milk cell concentrations, corticosteroids, and neutrophil phagocytosis in the cow. Am J Vet Res 1976;37:1195-200.
  8. Trevisan M, Browne R, Ram M, et al. Correlates of markers of oxidative status in the general population. Am J Epidemiol 2001;154:348-56. https://doi.org/10.1093/aje/154.4.348
  9. Sordillo LM, Aitken SL. Impact of oxidative stress on the health and immune function of dairy cattle. Vet Immunol Immunopathol 2009;128:104-9. https://doi.org/10.1016/j. vetimm.2008.10.305
  10. Shang X, Pan H, Li M, et al. Lonicera japonica thunb.: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. J Ethnopharmacol 2011;138:1-21. https://doi.org/10.1016/j.jep.2011.08.016
  11. Park KI, Kang SR, Park HS, et al. Regulation of proinflammatory mediators via $NF-{\kappa}B$and p38 MAPK-dependent mechanisms in RAW 264.7 macrophages by polyphenol components isolated from Korea Lonicera japonica THUNB. Evid Based Complement Alternat Med 2012;2012:Article ID828521. https://doi.org/10.1155/2012/828521
  12. Kang OH, Choi JG, Lee JH, Kwon D. Luteolin isolated from the flowers of Lonicera japonica suppresses inflammatory mediator release by blocking $NF-{\kappa}B$and MAPKs activation pathways in HMC-1 cells. Molecules 2010;15:385-98. https://doi.org/10.3390/molecules15010385
  13. Wu L, Zhang ZJ, Zhang ZS. Characterization of antioxidant activity of extracts from Flos Lonicerae. Drug Dev Ind Pharm 2007;33:841-7. https://doi.org/10.1080/03639040701378019
  14. Palikova I, Valentova K, Oborna I, Ulrichova J. Protectivity of blue honeysuckle extract against oxidative human endothelial cells and rat hepatocyte damage. J Agric Food Chem 2009;57:6584-9. https://doi.org/10.1021/jf9003994
  15. NRC (National Research Council). Nutrient requirements of dairy cattle. 7th rev. ed. Washington, DC, USA: National Academy Press; 2001.
  16. Xiang ZN, Ning ZX. Scavenging and antioxidant properties of compound derived from chlorogenic acid in South-China honeysuckle. LWT - Food Sci Technol 2008;41:1189-203. https://doi.org/10.1016/j.lwt.2007.08.006
  17. AOAC (Association of Official Analytical Chemists). Official methods of analysis, 15th ed. Arlington, VA, USA: AOAC International Press; 2011.
  18. Van Soest PJ, Robertson JB, Lewis BA. Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. J Dairy Sci 1991;74:3583-97. https://doi.org/10.3168/jds.S0022-0302(91)78551-2
  19. Jacometo CB, Osorio JS, Socha M, et al. Maternal consumption of organic trace minerals alters calf systemic and neutrophil mRNA and microRNA indicators of inflammation and oxidative stress. J Dairy Sci 2015;98:7717-29. https://doi.org/10.3168/jds.2015-9359
  20. Doepel L, Lapierre H, Kennelly JJ. Peripartum performance and metabolism of dairy cows in response to prepartum energy and protein intake. J Dairy Sci 2002;85;2315-34. https://doi.org/10.3168/jds.S0022-0302(02)74312-9
  21. Breen JE, Bradley AJ, Green MJ. Quarter and cow risk factors associated with a somatic cell count greater than 199,000 cells per milliliter in United Kingdom dairy cows. J Dairy Sci 2009;92:3106-15. https://doi.org/10.3168/jds.2008-1562
  22. Ruan Z, Yang YH, Zhou Y, et al. Metabolomic analysis of amino acid and energy metabolism in rats supplemented with chlorogenic acid. Amino Acids 2014;46:2219-29. https://doi.org/10.1007/s00726-014-1762-7
  23. Abuelo A, Hernandez J, Benedito JL, Castillo C. The importance of the oxidative status of dairy cattle in the periparturient period: revisiting antioxidant supplementation. J Anim Physiol Anim Nutr 2015;99:1003-16. https://doi.org/10.1111/jpn.12273
  24. Zhou Z, Bulgari O, Vailati-Riboni M, et al. Rumen-protected methionine compared with rumen-protected choline improves immunometabolic status in dairy cows during the peripartal period. J Dairy Sci 2016;99:8956-69. https://doi.org/10.3168/jds.2016-10986
  25. Kampa M, Nistikaki A, Tsaousis V, Maliaraki N, Notas G, Castanas E. A new automated method for the determination of the Total Antioxidant Capacity (TAC) of human plasma, based on the crocin bleaching assay. BMC Clin Pathol 2002;2:3. https://doi.org/10.1186/1472-6890-2-3
  26. Aldred EM, Buck C, Vall K. Chapter 7 - Free radicals. In: Aldred EM, Buck C, Vall K, editors. Pharmacology. London, UK: Churchill Livingstone; 2009.
  27. Oviedo-Boyso J, Valdez-Alarcon JJ, Cajero-Juarez M, et al. Innate immune response of bovine mammary gland to pathogenic bacteria responsible for mastitis. J Infect 2007;54:399-409. https://doi.org/10.1016/j.jinf.2006.06.010
  28. Koets AP, de Schwartz N, Tooten P, et al. Release of proinflammatory cytokines related to luteolysis and the periparturient acute phase response in prostaglandin-induced parturition in cows. Theriogenology 1998;49:797-812. https://doi.org/10.1016/S0093-691X(98)00029-6
  29. Hart KJ, Yanez-Ruiz DR, Duval SM, McEwan NR, Newbold CJ. Plant extracts to manipulate rumen fermentation. Anim Feed Sci Technol 2008;147:8-35. https://doi.org/10.1016/j.anifeedsci.2007.09.007
  30. Firkins JL, Hristov AN, Hall MB, Varga GA, St-Pierre NR. Integration of ruminal metabolism in dairy cattle. J Dairy Sci 2006;89(Suppl 1):E31-51. https://doi.org/10.3168/jds.S0022-0302(06)72362-1

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