대한한의학방제학회지 (Herbal Formula Science)

  • 제28권2호
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  • Pages.189-198
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  • 2020
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
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알코올 유발 간 손상 마우스 모델에서 복합 추출물 MJY2018의 간 보호 및 항산화 효과

Herbal formula MJY2018 protects against Alcohol-induced liver injury mice model

  • 김광연 (한국한의학연구원 한의기술응용센터) ;
  • 박광일 (한국한의학연구원 한의기술응용센터) ;
  • 조원경 (한국한의학연구원 한의기술응용센터) ;
  • 양주혜 (한국한의학연구원 한의기술응용센터) ;
  • 마진열 (한국한의학연구원 한의기술응용센터)
  • Kim, Kwang-Youn (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM)) ;
  • Park, Kwang-Il (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM)) ;
  • Cho, Won-Kyung (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM)) ;
  • Yang, Ju-Hye (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM)) ;
  • Ma, Jin-Yeul (Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM))
  • 투고 : 2020.04.24
  • 심사 : 2020.05.29
  • 발행 : 2020.05.31
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초록

Objectives : This study investigated the liver-protective effects of MJY2018, a Herbal formula, against alcoholic fatty liver disease and anti-oxidative effects. Methods : Its effects were investigated in an alcoholic fatty liver disease model in male C57BL/6 mice, which were fed Lieber-DeCarli liquid diet containing ethanol. MJY2018 (100 and 200 mg/kg bw/day) or silymarin (50 mg/kg bw/day) were orally administered daily in the alcoholic fatty liver disease mice for 16 days. Results : The results indicate that MJY2018 promotes hepatoprotection by significantly reducing aspartate transaminase (AST) and alanine transaminase (ALT) levels as indicators of liver damage in the serum. Furthermore, MJY2018 reduced accumulation of triglyceride and total cholesterol, increased levels of superoxide dismutase (SOD) and glutathione (GSH) in the livers of the alcoholic fatty liver disease mice model. Additionally, it improved the serum alcohol dehydrogenase (ADH) activity. Conclusions : These results indicate that MJY2018 were effective in improving and protecting oxidative stress and alcoholic liver disease.

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참고문헌

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