References
- Altman, B.J., Hsieh, A.L., Sengupta, A., Krishnanaiah, S.Y., Stine, Z.E., Walton, Z.E., Gouw, A.M., Venkataraman, A., Li, B., Goraksha-Hicks, P., et al. (2015). MYC disrupts the circadian clock and metabolism in cancer cells. Cell Metab. 22, 1009-1019. https://doi.org/10.1016/j.cmet.2015.09.003
- Bailey, A.M., Zhan, L., Maru, D., Shureiqi, I., Pickering, C.R., Kiriakova, G., Izzo, J., He, N., Wei, C., Baladandayuthapani, V., et al. (2014). FXR silencing in human colon cancer by DNA methylation and KRAS signaling. Am. J. Physiol. Gastrointest. Liver Physiol. 306, G48-G58. https://doi.org/10.1152/ajpgi.00234.2013
- Bonamy, C., Sechet, E., Amiot, A., Alam, A., Mourez, M., Fraisse, L., Sansonetti, P.J., and Sperandio, B. (2018). Expression of the human antimicrobial peptide beta-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells. Sci. Rep. 8, 18043. https://doi.org/10.1038/s41598-018-36387-z
- Cancer Genome Atlas Network. (2012). Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337. https://doi.org/10.1038/nature11252
- Cao, Z., Fan-Minogue, H., Bellovin, D.I., Yevtodiyenko, A., Arzeno, J., Yang, Q., Gambhir, S.S., and Felsher, D.W. (2011). MYC phosphorylation, activation, and tumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoA reductase. Cancer Res. 71, 2286-2297. https://doi.org/10.1158/0008-5472.CAN-10-3367
- Chen, H., Liu, H., and Qing, G. (2018). Targeting oncogenic Myc as a strategy for cancer treatment. Signal Transduct. Target. Ther. 3, 5. https://doi.org/10.1038/s41392-018-0008-7
- Conacci-Sorrell, M., McFerrin, L., and Eisenman, R.N. (2014). An overview of MYC and its interactome. Cold Spring Harb. Perspect. Med. 4, a014357. https://doi.org/10.1101/cshperspect.a014357
- Dang, C.V. (2012). MYC on the path to cancer. Cell 149, 22-35. https://doi.org/10.1016/j.cell.2012.03.003
- Date, Y. and Ito, K. (2020). Oncogenic RUNX3: a link between p53 deficiency and MYC dysregulation. Mol. Cells 43, 176-181. https://doi.org/10.14348/molcells.2019.0285
- de Aguiar Vallim, T.Q., Tarling, E.J., and Edwards, P.A. (2013). Pleiotropic roles of bile acids in metabolism. Cell Metab. 17, 657-669. https://doi.org/10.1016/j.cmet.2013.03.013
- DeBerardinis, R.J. and Chandel, N.S. (2016). Fundamentals of cancer metabolism. Sci. Adv. 2, e1600200. https://doi.org/10.1126/sciadv.1600200
- Degirolamo, C., Modica, S., Palasciano, G., and Moschetta, A. (2011). Bile acids and colon cancer: solving the puzzle with nuclear receptors. Trends Mol. Med. 17, 564-572. https://doi.org/10.1016/j.molmed.2011.05.010
- Frenzel, A., Zirath, H., Vita, M., Albihn, A., and Henriksson, M.A. (2011). Identification of cytotoxic drugs that selectively target tumor cells with MYC overexpression. PLoS One 6, e27988. https://doi.org/10.1371/journal.pone.0027988
- Fu, T., Coulter, S., Yoshihara, E., Oh, T.G., Fang, S., Cayabyab, F., Zhu, Q., Zhang, T., Leblanc, M., Liu, S., et al. (2019). FXR regulates intestinal cancer stem cell proliferation. Cell 176, 1098-1112.e18. https://doi.org/10.1016/j.cell.2019.01.036
- Garcia-Gutierrez, L., Delgado, M.D., and Leon, J. (2019). MYC oncogene contributions to release of cell cycle brakes. Genes (Basel) 10, 244. https://doi.org/10.3390/genes10030244
- Gomez-Ospina, N., Potter, C.J., Xiao, R., Manickam, K., Kim, M.S., Kim, K.H., Shneider, B.L., Picarsic, J.L., Jacobson, T.A., Zhang, J., et al. (2016). Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nat. Commun. 7, 10713. https://doi.org/10.1038/ncomms10713
- Guinney, J., Dienstmann, R., Wang, X., de Reynies, A., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., et al. (2015). The consensus molecular subtypes of colorectal cancer. Nat. Med. 21, 1350-1356. https://doi.org/10.1038/nm.3967
- Houlston, R.S. (2001). What we could do now: molecular pathology of colorectal cancer. Mol. Pathol. 54, 206-214. https://doi.org/10.1136/mp.54.4.206
- Hsieh, A.L., Walton, Z.E., Altman, B.J., Stine, Z.E., and Dang, C.V. (2015). MYC and metabolism on the path to cancer. Semin. Cell Dev. Biol. 43, 11-21. https://doi.org/10.1016/j.semcdb.2015.08.003
- Jo, M.J., Paek, A.R., Choi, J.S., Ok, C.Y., Jeong, K.C., Lim, J.H., Kim, S.H., and You, H.J. (2015). Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment. Eur. J. Pharmacol. 769, 257-265. https://doi.org/10.1016/j.ejphar.2015.11.027
- Kazi, A., Xiang, S., Yang, H., Delitto, D., Trevino, J., Jiang, R.H.Y., Ayaz, M., Lawrence, H.R., Kennedy, P., and Sebti, S.M. (2018). GSK3 suppression upregulates beta-catenin and c-Myc to abrogate KRas-dependent tumors. Nat. Commun. 9, 5154. https://doi.org/10.1038/s41467-018-07644-6
- Klag, T., Thomas, M., Ehmann, D., Courth, L., Mailander-Sanchez, D., Weiss, T.S., Dayoub, R., Abshagen, K., Vollmar, B., Thasler, W.E., et al. (2018). Beta-defensin 1 is prominent in the liver and induced during cholestasis by bilirubin and bile acids via farnesoid X receptor and constitutive androstane receptor. Front. Immunol. 9, 1735. https://doi.org/10.3389/fimmu.2018.01735
- Kong, B., Zhu, Y., Li, G., Williams, J.A., Buckley, K., Tawfik, O., Luyendyk, J.P., and Guo, G.L. (2016). Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 310, G295-G302. https://doi.org/10.1152/ajpgi.00134.2015
- Kuipers, E.J., Grady, W.M., Lieberman, D., Seufferlein, T., Sung, J.J., Boelens, P.G., van de Velde, C.J., and Watanabe, T. (2015). Colorectal cancer. Nat. Rev. Dis. Primers 1, 15065. https://doi.org/10.1038/nrdp.2015.65
- Lajczak, N.K., Saint-Criq, V., O'Dwyer, A.M., Perino, A., Adorini, L., Schoonjans, K., and Keely, S.J. (2017). Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human beta-defensin-1 and -2 secretion by colonic epithelial cells. FASEB J. 31, 3848-3857. https://doi.org/10.1096/fj.201601365R
- Leonetti, C., Biroccio, A., Candiloro, A., Citro, G., Fornari, C., Mottolese, M., Del Bufalo, D., and Zupi, G. (1999). Increase of cisplatin sensitivity by c-myc antisense oligodeoxynucleotides in a human metastatic melanoma inherently resistant to cisplatin. Clin. Cancer Res. 5, 2588-2595.
- Luengo, A., Gui, D.Y., and Vander Heiden, M.G. (2017). Targeting metabolism for cancer therapy. Cell Chem. Biol. 24, 1161-1180. https://doi.org/10.1016/j.chembiol.2017.08.028
- Maran, R.R., Thomas, A., Roth, M., Sheng, Z., Esterly, N., Pinson, D., Gao, X., Zhang, Y., Ganapathy, V., Gonzalez, F.J., et al. (2009). Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. J. Pharmacol. Exp. Ther. 328, 469-477. https://doi.org/10.1124/jpet.108.145409
- Nagarajan, A., Malvi, P., and Wajapeyee, N. (2016). Oncogene-directed alterations in cancer cell metabolism. Trends Cancer 2, 365-377. https://doi.org/10.1016/j.trecan.2016.06.002
- Okita, A., Takahashi, S., Ouchi, K., Inoue, M., Watanabe, M., Endo, M., Honda, H., Yamada, Y., and Ishioka, C. (2018). Consensus molecular subtypes classification of colorectal cancer as a predictive factor for chemotherapeutic efficacy against metastatic colorectal cancer. Oncotarget 9, 18698-18711. https://doi.org/10.18632/oncotarget.24617
- Okuyama, H., Endo, H., Akashika, T., Kato, K., and Inoue, M. (2010). Downregulation of c-MYC protein levels contributes to cancer cell survival under dual deficiency of oxygen and glucose. Cancer Res. 70, 10213-10223. https://doi.org/10.1158/0008-5472.CAN-10-2720
- Ortmayr, K., Dubuis, S., and Zampieri, M. (2019). Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism. Nat. Commun. 10, 1841. https://doi.org/10.1038/s41467-019-09695-9
- Rahl, P.B., Lin, C.Y., Seila, A.C., Flynn, R.A., McCuine, S., Burge, C.B., Sharp, P.A., and Young, R.A. (2010). c-Myc regulates transcriptional pause release. Cell 141, 432-445. https://doi.org/10.1016/j.cell.2010.03.030
- Ran, F.A., Hsu, P.D., Wright, J., Agarwala, V., Scott, D.A., and Zhang, F. (2013). Genome engineering using the CRISPR-Cas9 system. Nat. Protoc. 8, 2281-2308. https://doi.org/10.1038/nprot.2013.143
- Sarosiek, K.A., Fraser, C., Muthalagu, N., Bhola, P.D., Chang, W., McBrayer, S.K., Cantlon, A., Fisch, S., Golomb-Mello, G., Ryan, J.A., et al. (2017). Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics. Cancer Cell 31, 142-156. https://doi.org/10.1016/j.ccell.2016.11.011
- Satoh, K., Yachida, S., Sugimoto, M., Oshima, M., Nakagawa, T., Akamoto, S., Tabata, S., Saitoh, K., Kato, K., Sato, S., et al. (2017). Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. Proc. Natl. Acad. Sci. U. S. A. 114, E7697-E7706. https://doi.org/10.1073/pnas.1710366114
- Sears, R., Nuckolls, F., Haura, E., Taya, Y., Tamai, K., and Nevins, J.R. (2000). Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 14, 2501-2514. https://doi.org/10.1101/gad.836800
- Smith, D.R., Myint, T., and Goh, H.S. (1993). Over-expression of the c-myc proto-oncogene in colorectal carcinoma. Br. J. Cancer 68, 407-413. https://doi.org/10.1038/bjc.1993.350
- Soucek, L., Whitfield, J., Martins, C.P., Finch, A.J., Murphy, D.J., Sodir, N.M., Karnezis, A.N., Swigart, L.B., Nasi, S., and Evan, G.I. (2008). Modelling Myc inhibition as a cancer therapy. Nature 455, 679-683. https://doi.org/10.1038/nature07260
- Stine, Z.E., Walton, Z.E., Altman, B.J., Hsieh, A.L., and Dang, C.V. (2015). MYC, metabolism, and cancer. Cancer Discov. 5, 1024-1039. https://doi.org/10.1158/2159-8290.CD-15-0507
- Sveen, A., Bruun, J., Eide, P.W., Eilertsen, I.A., Ramirez, L., Murumagi, A., Arjama, M., Danielsen, S.A., Kryeziu, K., Elez, E., et al. (2018). Colorectal cancer consensus molecular subtypes translated to preclinical models uncover potentially targetable cancer cell dependencies. Clin. Cancer Res. 24, 794-806. https://doi.org/10.1158/1078-0432.CCR-17-1234
- Takahashi, S., Tanaka, N., Fukami, T., Xie, C., Yagai, T., Kim, D., Velenosi, T.J., Yan, T., Krausz, K.W., Levi, M., et al. (2018). Role of farnesoid X receptor and bile acids in hepatic tumor development. Hepatol. Commun. 2, 1567-1582. https://doi.org/10.1002/hep4.1263
Cited by
- Identification of a Metabolism-Related Risk Signature Associated With Clinical Prognosis in Glioblastoma Using Integrated Bioinformatic Analysis vol.10, 2020, https://doi.org/10.3389/fonc.2020.01631
- Identification of an Innate Immune-Related Prognostic Signature in Early-Stage Lung Squamous Cell Carcinoma vol.14, 2020, https://doi.org/10.2147/ijgm.s341175
- Adhesion of Platelets to Colon Cancer Cells Is Necessary to Promote Tumor Development in Xenograft, Genetic and Inflammation Models vol.13, pp.16, 2020, https://doi.org/10.3390/cancers13164243