참고문헌
- Canalis, E., Economides, A.N., and Gazzerro, E. (2003). Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr. Rev. 24, 218-235. https://doi.org/10.1210/er.2002-0023
- Fischer, J., Koch, L., Emmerling, C., Vierkotten, J., Peters, T., Bruning, J.C., and Ruther, U. (2009). Inactivation of the Fto gene protects from obesity. Nature 458, 894-898. https://doi.org/10.1038/nature07848
- Frayling, T.M., Timpson, N.J., Weedon, M.N., Zeggini, E., Freathy, R.M., Lindgren, C.M., Perry, J.R., Elliott, K.S., Lango, H., Rayner, N.W., et al. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894. https://doi.org/10.1126/science.1141634
- Gething, M.J. and Sambrook, J. (1992). Protein folding in the cell. Nature 355, 33-45. https://doi.org/10.1038/355033a0
- Ghemrawi, R., Battaglia-Hsu, S.F., and Arnold, C. (2018). Endoplasmic reticulum stress in metabolic disorders. Cells 7, E63. https://doi.org/10.3390/cells7060063
- Guo, J., Ren, W., Li, A., Ding, Y., Guo, W., Su, D., Hu, C., Xu, K., Chen, H., Xu, X., et al. (2013). Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease. Dig. Dis. Sci. 58, 1004-1009. https://doi.org/10.1007/s10620-012-2516-6
- Guo, Y., Liu, H., Yang, T.L., Li, S.M., Li, S.K., Tian, Q., Liu, Y.J., and Deng, H.W. (2011). The fat mass and obesity associated gene, FTO, is also associated with osteoporosis phenotypes. PLoS One 6, e27312. https://doi.org/10.1371/journal.pone.0027312
- Jang, H., Kim, E.J., Park, J.K., Kim, D.E., Kim, H.J., Sun, W.S., Hwang, S., Oh, K.B., Koh, J.T., Jang, W.G., et al. (2014). SMILE inhibits BMP-2-induced expression of osteocalcin by suppressing the activity of the RUNX2 transcription factor in MC3T3E1 cells. Bone 61, 10-18. https://doi.org/10.1016/j.bone.2013.12.028
- Jang, W.G., Kim, E.J., Kim, D.K., Ryoo, H.M., Lee, K.B., Kim, S.H., Choi, H.S., and Koh, J.T. (2012). BMP2 protein regulates osteocalcin expression via Runx2-mediated Atf6 gene transcription. J. Biol. Chem. 287, 905-915. https://doi.org/10.1074/jbc.M111.253187
- Jang, W.G., Kim, E.J., and Koh, J.T. (2011a). Tunicamycin negatively regulates BMP2-induced osteoblast differentiation through CREBH expression in MC3T3E1 cells. BMB Rep. 44, 735-740. https://doi.org/10.5483/BMBRep.2011.44.11.735
- Jang, W.G., Kim, E.J., Lee, K.N., Son, H.J., and Koh, J.T. (2011b). AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells. Biochem. Biophys. Res. Commun. 404, 1004-1009. https://doi.org/10.1016/j.bbrc.2010.12.099
- Javed, A., Bae, J.S., Afzal, F., Gutierrez, S., Pratap, J., Zaidi, S.K., Lou, Y., van Wijnen, A.J., Stein, J.L., Stein, G.S., et al. (2008). Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal. J. Biol. Chem. 283, 8412-8422. https://doi.org/10.1074/jbc.M705578200
- Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.G., et al. (2011). N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 7, 885-887. https://doi.org/10.1038/nchembio.687
- Jung, T.W., Kim, H.C., Abd El-Aty, A.M., and Jeong, J.H. (2017). Protectin DX suppresses hepatic gluconeogenesis through AMPK-HO-1-mediated inhibition of ER stress. Cell Signal. 34, 133-140. https://doi.org/10.1016/j.cellsig.2017.03.013
- Kanazawa, I., Yamaguchi, T., Yano, S., Yamauchi, M., and Sugimoto, T. (2008). Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression. Biochem. Biophys. Res. Commun. 375, 414-419. https://doi.org/10.1016/j.bbrc.2008.08.034
- Kim, D.Y., Kim, E.J., and Jang, W.G. (2018). Piperine induces osteoblast differentiation through AMPK-dependent Runx2 expression. Biochem. Biophys. Res. Commun. 495, 1497-1502. https://doi.org/10.1016/j.bbrc.2017.11.200
- Komori, T. (2006). Regulation of osteoblast differentiation by transcription factors. J. Cell. Biochem. 99, 1233-1239. https://doi.org/10.1002/jcb.20958
- Leclerc, G.M., Leclerc, G.J., Kuznetsov, J.N., DeSalvo, J., and Barredo, J.C. (2013). Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts. PLoS One 8, e74420. https://doi.org/10.1371/journal.pone.0074420
- Lee, J. and Ozcan, U. (2014). Unfolded protein response signaling and metabolic diseases. J. Biol. Chem. 289, 1203-1211. https://doi.org/10.1074/jbc.R113.534743
- Li, J., Huang, J., Li, J.S., Chen, H., Huang, K., and Zheng, L. (2012). Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. J. Hepatol. 56, 900-907. https://doi.org/10.1016/j.jhep.2011.10.018
- Li, J., Lee, B., and Lee, A.S. (2006). Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J. Biol. Chem. 281, 7260-7270. https://doi.org/10.1074/jbc.M509868200
- Lim, A., Zhou, J., Sinha, R.A., Singh, B.K., Ghosh, S., Lim, K.H., Chow, P.K.H., Woon, E.C., and Yen, P.M. (2016). Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. Biochem. Biophys. Res. Commun. 479, 476-481. https://doi.org/10.1016/j.bbrc.2016.09.086
- Murakami, T., Saito, A., Hino, S., Kondo, S., Kanemoto, S., Chihara, K., Sekiya, H., Tsumagari, K., Ochiai, K., Yoshinaga, K., et al. (2009). Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat. Cell Biol. 11, 1205-1211. https://doi.org/10.1038/ncb1963
- Oakhill, J.S., Scott, J.W., and Kemp, B.E. (2009). Structure and function of AMP-activated protein kinase. Acta Physiol. 196, 3-14. https://doi.org/10.1111/j.1748-1716.2009.01977.x
- Ozcan, U., Cao, Q., Yilmaz, E., Lee, A.H., Iwakoshi, N.N., Ozdelen, E., Tuncman, G., Gorgun, C., Glimcher, L.H., and Hotamisligil, G.S. (2004). Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457-461. https://doi.org/10.1126/science.1103160
- Pitman, R.T., Fong, J.T., Stone, A.L., Devito, J.T., and Puri, N. (2013). FTO knockdown decreases phosphorylation of Tau in neuronal cells: a potential model implicating the association of FTO with Alzheimer's disease. J. Alzheimers Dis. Parkinsonism 3, 125.
- Soeda, J., Cordero, P., Li, J., Mouralidarane, A., Asilmaz, E., Ray, S., Nguyen, V., Carter, R., Novelli, M., Vinciguerra, M., et al. (2017). Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high-fat diet-induced obesity. Int. J. Food Sci. Nutr. 68, 455-466. https://doi.org/10.1080/09637486.2016.1261086
- Son, H.E., Kim, E.J., and Jang, W.G. (2018a). Curcumin induces osteoblast differentiation through mild-endoplasmic reticulum stress-mediated such as BMP2 on osteoblast cells. Life Sci. 193, 34-39. https://doi.org/10.1016/j.lfs.2017.12.008
- Son, H.E., Kim, K.M., Kim, E.J., and Jang, W.G. (2018b). Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci. Rep. 8, 2134. https://doi.org/10.1038/s41598-018-20571-2
- Tews, D., Fischer-Posovszky, P., and Wabitsch, M. (2010). FTO - Friend or foe? Horm. Metab. Res. 42, 75-80. https://doi.org/10.1055/s-0029-1241831
- Wozney, J.M. (1998). The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult. Eur. J. Oral. Sci. 106 Suppl 1, 160-166. https://doi.org/10.1111/j.1600-0722.1998.tb02170.x
- Wu, W., Feng, J., Jiang, D., Zhou, X., Jiang, Q., Cai, M., Wang, X., Shan, T., and Wang, Y. (2017). AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N(6)-methyladenosine. Sci. Rep. 7, 41606. https://doi.org/10.1038/srep41606
- Yamaguchi, A., Komori, T., and Suda, T. (2000). Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr. Rev. 21, 393-411. https://doi.org/10.1210/edrv.21.4.0403
- Zhao, X., Yang, Y., Sun, B.F., Shi, Y., Yang, X., Xiao, W., Hao, Y.J., Ping, X.L., Chen, Y.S., Wang, W.J., et al. (2014). FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res. 24, 1403-1419. https://doi.org/10.1038/cr.2014.151
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