대한예방한의학회지 (Journal of Society of Preventive Korean Medicine)

대한예방한의학회 (Society of Preventive Korean Medicine)
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산조인탕치료가 여성갱년기 수면장애에 미치는 효과 : 체계적 문헌고찰 및 메타분석

Sanjoin-tang (Suanzaoren decoction) for Insomnia in Menopausal Syndromes: A Systematic Review and Meta-analysis

  • 전지희 (대전대학교 한의과대학 예방의학교실 대학원) ;
  • 최태영 (한국한의학연구원 임상의학부) ;
  • 이명수 (한국한의학연구원 임상의학부) ;
  • 송은혜 (대전대학교 한의과대학 예방의학교실 대학원) ;
  • ;
  • 박선주 (대전대학교 한의과대학 예방의학교실)
  • Jun, Ji Hee (Department of Preventive Medicine, College of Korean Medicine, Daejeon University) ;
  • Choi, Tae-Young (Clinical Medicine Division, Korea Institute of Oriental Medicine) ;
  • Lee, Myeong Soo (Clinical Medicine Division, Korea Institute of Oriental Medicine) ;
  • Song, Eunhye (Department of Preventive Medicine, College of Korean Medicine, Daejeon University) ;
  • Ang, Lin (Korea University of Science and Technology, Korean Convergence Medicine) ;
  • Park, Sunju (Department of Preventive Medicine, College of Korean Medicine, Daejeon University)
  • 투고 : 2020.03.04
  • 심사 : 2020.03.20
  • 발행 : 2020.04.30
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초록

Objectives : The purpose of this systematic review was to investigate the efficacy and safety of Sanjoin-tang (Suanzaoren decoction, SZRD) for insomnia in menopausal syndromes. Method : We searched the following databases: PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Science and Technique Journals Database (VIP), Wanfang, Research Information Service System (RISS), OASIS, Korean studies Information Service System (KISS), and National Digital Science Library (NDSL) databases. Randomized controlled trials (RCTs) or quasi-RCTs that used SZRD for women in menopause were included. The methodological quality of each RCT was assessed using the risk of bias tool. Results : In total, nine RCTs were finally included. The included RCTs had a high risk of bias across their domains. Three RCTs examined the effects of SZRD compared with western medicine (WM) in insomnia. Three RCTs showed favorable effects of SZRD with insomnia. Infrastructure also showed that SZRD resulted in better clinical WM (RR 1.19, 95% CI 1.07 to 1.32, P=0.001, I2=0%). Four RCTs showed favorable effects of Modified SZRD with insomnia. Infrastructure also showed that Modified SZRD resulted in better clinical WM (RR 1.13, 95% CI 1.04 to 1.23, P=0.004, I2=0%). Among the 4 RCTs, three RCTs showed an equivalent effect on the total Pittsburh Sleep Quality Index (PSQI). The meta-analysis also showed that Modified SZRD had a superior effect on the total of PSQI (total of PSQI : MD -2.55, 95% CI -3.72 to -1.37, P<0.0001, I2=85%). Only 2 trials reported adverse events and none reported severe adverse events. Conclusion : SZRD appears to be safe, but there is insufficient evidence to make a definitive conclusion because only a few studies reported adverse events. Due to the poor methodological quality of the included studies and the small number of trials included, the evidence cannot be reproduced and assessed. Well-designed RCTs with a larger sample size are needed in the future.

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