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A Case Report of FOLFOX-induced Adverse Events in a Patient with Recurrent Advanced Gastric Cancer Treated with Korean Medicine

재발 진행성 위암 환자의 FOLFOX 유발 부작용 개선에 대한 한의 치료 1례

  • Ko, Myung-hyun (East West Cancer Center, Dunsan Korean Medicine Hospital of Dae-Jeon University) ;
  • Yang, Jae-ho (East West Cancer Center, Dunsan Korean Medicine Hospital of Dae-Jeon University) ;
  • Jeon, Hyung-joon (East West Cancer Center, Seoul Korean Medicine Hospital of Dae-Jeon University) ;
  • Cho, Chong-kwan (East West Cancer Center, Dunsan Korean Medicine Hospital of Dae-Jeon University) ;
  • Lee, Yeon-weol (East West Cancer Center, Dunsan Korean Medicine Hospital of Dae-Jeon University) ;
  • Park, So-jung (East West Cancer Center, Dunsan Korean Medicine Hospital of Dae-Jeon University) ;
  • Yoo, Hwa-seung (East West Cancer Center, Seoul Korean Medicine Hospital of Dae-Jeon University)
  • 고명현 (대전대학교 둔산한방병원 동서암센터) ;
  • 양재호 (대전대학교 둔산한방병원 동서암센터) ;
  • 전형준 (대전대학교 서울한방병원 동서암센터) ;
  • 조종관 (대전대학교 둔산한방병원 동서암센터) ;
  • 이연월 (대전대학교 둔산한방병원 동서암센터) ;
  • 박소정 (대전대학교 둔산한방병원 동서암센터) ;
  • 유화승 (대전대학교 서울한방병원 동서암센터)
  • Received : 2020.02.11
  • Accepted : 2020.03.27
  • Published : 2020.04.20

Abstract

Objective: The purpose of this study was to report the clinical effectiveness of Korean medicine treatment on FOLFOX-induced symptoms such as nausea and dizziness in a patient with recurrent advanced gastric adenocarcinoma. Methods: The patient was diagnosed with recurrent advanced gastric cancer and had FOLFOX-induced nausea and dizziness. The patient was treated with Samchulgunbi-tang and Banhasashim-tang for symptom management. The clinical outcomes were measured by National Cancer Institute Common Terminology Criteria for Adverse Event (NCI CTCAE) and a numeral rating scale (NRS). Results: After treatment, the patient's nausea and dizziness were relieved from NRS 9 to 2 and NRS 8 to 2 respectively. During and after treatment, no severe toxicities were detected on laboratory findings. Conclusion: This case study suggests that Samchulgunbi-tang and Banhasashim-tang may relieve symptoms of FOLFOX-induced nausea and dizziness.

Keywords

References

  1. Korea Central Cancer Registry Annual report of cancer statistics in Korea in 2016. 2018.
  2. National Cancer Information Center. Gastric Cancer Available from http://www.cancer.go.kr
  3. Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H. Gastric cancer. The Lancet 2016;388(10060):2654-64. https://doi.org/10.1016/S0140-6736(16)30354-3
  4. Lee CW, Park MI, Park SJ, Moon W, Kim HH, Lee HW. Original Articles : Gastroenterology ; FOLFOX-4 Combination Chemotherapy as a First-Line Treatment in Patients with Advanced Gastric Cancer. Korean J Med 2012;82(1):37-44. https://doi.org/10.3904/kjm.2012.82.1.37
  5. Wang J, Qu J, Li Z, Che X, Zhang J, Liu J, et al. A prognostic model in metastatic or recurrent gastric cancer patients with good performance status who received first-line chemotherapy. Translational oncology 2016;9(3):256-61. https://doi.org/10.1016/j.tranon.2016.04.004
  6. 전국 한의과대학 비계 내과학교실. 비계 내과학 Seoul: 군자출판사; 2008, p. 353-4.
  7. 안윤옥. Gastric cancer Etiology and Prevention. 대한의학협회지 1992;35(7):820-7.
  8. Lee CI, Shim KY, Kim HY, Choi SY, Bang DG, Cho KS. Clinical Study of the Efficacy of Combined Western-Oriental Medicine for Gastric Cancer and Hepatocellular Carcinoma. J of Kor Traditional Oncology 2001;7(1):117-29.
  9. Lee SH, Ahn BK, Baek SU. Clinical Trial of Oxaliplatin, 5-Fluorocuracil, and Leucovorin in Advanced Colorectal Cancer: 48 Cases. J of Korean Soc coloproctol 2002;18(6):402-7.
  10. 최승훈. 東醫腫瘍學. Seoul: 행림; 1995, p. 178-87, 194-9.
  11. Seo YC, Im SU, Lee WC. A Brief Study on Prescriptional Operation and Combined Treatment with Chemical Therapy of Gastric Cancer (Focusing on Chinese Medical Journal After 1990). J of Kor Traditional Oncology 1997;3(1):193-206.
  12. Lee JC, Yoon HY, Yoo HS, Bang SH. A Case Report of Complete Response of Advanced Gastric Carcinoma Patient Treated with Korean Medicine Treatment in Conjunction with Chemoradiation Therapy. J of Kor Traditional Oncology 2014;9(1):25-32.
  13. Kim HR, Yoo HS, Baek DG, Park IH, Jang CY, Kim HY, et al. Clinical Practice Guidelines in Korean Medicine for Gastric Cancer. J of Int Korean Med 2016;37(1):26-46.
  14. Lin H. Guideline of Diagnosis and Therapy in Oncology with Traditional Chinese Medicine. Beijing: Beijing renminweisheng press; 2014, p. 306-38.
  15. Kook GH, Lim LC, Kim SH. Bibliographic study on treating method of antitumor and prescription for the side effect by chemotherapy and radiotherapy. Korean Journal of Oriental Physiology & Pathology 1995;9(2):45-87.
  16. Kim TG, Ko SG, Baek TH. An experimental study on the effect of Samchulgunbitang affecting gastro-intestine and central nervous system. J Int Korean med 1997;18(1):1-14.
  17. Ahn SB, Lee GY, Hwang HH, Jeong MJ, Jang IS. The Effect of Banhasasim-tang in the Treatment of Chemotherapy-induced Symptoms: A Systematic Review. J Int Korean med 2019;40(4):663-74. https://doi.org/10.22246/jikm.2019.40.4.663
  18. Wang L. 40 case series : combination of Chinese and western medicine to prevent gastrointestinal reaction caused by chemotherapy. J of Traditional Chinese Medicine 2010;41(329):42-3.
  19. Yoon SH, Ryu BH, Ryu KW, Kim JS. Evaluation for Therapeutic Effectiveness of Banwhasashim-tang in Functional Dyspepsia. J of East-West Med Research Institute 2003;24(3):259-66.