Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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Effect of a Gluten Free Diet on Hepatitis B Surface Antibody Concentration in Previously Immunized Pediatric Celiac Patients

  • Zifman, Eyal (Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel) ;
  • Zevit, Noam (Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel) ;
  • Heshin-Bekenstein, Merav (Department of Pediatric, Shaare Zedek Medical Center) ;
  • Turner, Dan (Pediatric Gastroenterology Institute, Shaare Zedek Medical Center and The Hebrew University of Jerusalem) ;
  • Shamir, Raanan (Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel) ;
  • Silbermintz, Ari (Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel)
  • Received : 2019.08.08
  • Accepted : 2019.11.30
  • Published : 2020.03.15
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Abstract

Purpose: To evaluate the effect of gluten-free diet (GFD) on hepatitis B surface antibody (HBsAb) concentrations among previously immunized pediatric celiac disease (CD) subjects. Methods: We retrospectively evaluated pediatric CD subjects in serological remission who were previously immunized for hepatitis B virus as infants. The temporal relationship between HBsAb concentration, the amount of time on a GFD, and age were evaluated. Results: Overall, 373 CD subjects were analyzed: 156 with HBsAb sampled prior to GFD initiation and 217 after initiation of a GFD and in serological remission. Median age at HBsAb concentration measurement for those before and after GFD initiation was 5.3 years (interquartile range [IQR], 3.1-9.2 years) and 7.6 years (IQR, 5.4-10.9 years), respectively (p<0.001). There was no sex difference between the groups. The median time of HBsAb measurement was 2 months (IQR, 0-5.7 months) before and 12.8 months (IQR, 5.3-30.3 months) after initiation of GFD. The HBsAb concentration was low in 79 (50.6%) and 121 (55.7%) subjects before and after GFD initiation, respectively (p=0.350). Age was inversely associated with low HBsAb concentrations. Neither being on a GFD nor sex was associated with low HBsAb concentrations. Conclusion: Adherence to a GFD does not affect HBsAb concentration in children with CD. Age is inversely associated with HBsAb concentration.

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References

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