Natural Product Sciences

  • 제26권4호
  • /
  • Pages.340-344
  • /
  • 2020
  • /
  • 1226-3907(pISSN)
  • /
  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지
DOI QR코드

DOI QR Code

Molecular Networking-based De-replication Strategy Leads to the Isolation of a New Chromone from Pleosporales sp.

  • Kwon, Haeun (Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University) ;
  • Kim, Jun Gu (College of Pharmacy, Chungbuk National University) ;
  • Oh, Jeong-Joo (Division of Environmental Science and Ecological Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Kim, Jae-Jin (Division of Environmental Science and Ecological Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Kim, Gyu-Hyeok (Division of Environmental Science and Ecological Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Hwang, Bang Yeon (College of Pharmacy, Chungbuk National University) ;
  • Yim, Joung Han (Korea Polar Research Institute) ;
  • Lee, Dongho (Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University)
  • 투고 : 2020.12.21
  • 심사 : 2020.12.29
  • 발행 : 2020.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

A new chromone analogue (1) was isolated from an EtOAc-extract of Pleosporales sp. culture medium, together with five known chromones (2 - 6). The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using NMR and MS spectroscopy, and the absolute configuration was established by the Mosher's method. All isolated compounds were evaluated for their inhibitory effects on lipopolysaccharide-induced nitirc oxide production in RAW 264.7 macrophages. Compound 1 showed marginal inhibitory activity with an IC50 value of 118.7 μM.

키워드

참고문헌

  1. Zhang, Y.; Crous, P. W.; Schoch, C. L.; Hyde, K. D. Fungal Divers. 2012, 53, 1-221. https://doi.org/10.1007/s13225-011-0117-x
  2. Pittayakhajonwut, P.; Dramae, A.; Madla, S.; Lartpornmatulee, N.; Boonyuen, N.; Tanticharoen, M. J. Nat. Prod. 2006, 69, 1361-1363. https://doi.org/10.1021/np060190c
  3. Yasuta, E.; Terahata, T.; Nakayama, M.; Abe, H.; Takatsuto, S.; Yokota, T. Biosci. Biotech. Biochem. 1995, 59, 2156-2158. https://doi.org/10.1271/bbb.59.2156
  4. Zhang, C.; Ondeyka, J. G.; Zink, D. L.; Basilio, A.; Vicente, F.; Collado, J.; Platas, G.; Bills, G.; Huber, J.; Dorso, K.; Motyl, M.; Byrne, K.; Singh, S. B. J. Nat. Prod. 2008, 71, 1304-1307. https://doi.org/10.1021/np8001833
  5. Yang, J. Y.; Sanchez, L. M.; Rath, C. M.; Liu, X.; Boudreau, P. D.; Bruns, N.; Glukhov, E.; Wodtke, A.; de Felicio, R.; Fenner, A.; Wong, W. R.; Linington, R. G.; Zhang, L.; Debonsi, H. M.; Gerwick, W. H.; Dorrestein, P. C. J. Nat. Prod. 2013, 76, 1686-1699. https://doi.org/10.1021/np400413s
  6. Wijeratne, E. M. K.; Turbyville, T. J.; Fritz, A.; Whitesell, L.; Gunatilaka, A. A. L. Bioorg. Med. Chem. 2006, 14, 7917-7923. https://doi.org/10.1016/j.bmc.2006.07.048
  7. Miao, C.; Wang, J.; Huang, R.; Liu, S.; Zheng, K.; Liu, C.; Lu, Y.; Wu, S. Folia Microbiol. 2020, 65, 567-572. https://doi.org/10.1007/s12223-019-00762-8
  8. Carroll, A. R.; Nash, B. D.; Duffy, S.; Avery, V. M. J. Nat. Prod. 2012, 75, 1206-1209. https://doi.org/10.1021/np300074z
  9. Kim, J. G.; Le, T. P. L.; Hong, H. R.; Han, J. S.; Ko, J. H.; Lee, S. H.; Lee, M. K.; Hwang, B. Y. Nat. Prod. Sci. 2019, 25, 76-80. https://doi.org/10.20307/nps.2019.25.1.76
  10. Paz, W. H. P.; de Oliveira, R. N.; Heerdt, G.; Angolini, C. F. F.; de Medeiros, L. S.; Silva, V. R.; Santos, L. S.; Soares, M. B. P.; Bezerra, D. P.; Morgon, N. H.; Almeida, J. R. G. S.; da Silva, F. M. A.; Costa, E. V.; Koolen, H. H. F. J. Nat. Prod. 2019, 82, 2220-2228. https://doi.org/10.1021/acs.jnatprod.9b00287

피인용 문헌

  1. A new α-pyrone from Arthrinium pseudosinense culture medium and its estrogenic activity in MCF-7 cells vol.74, pp.12, 2020, https://doi.org/10.1038/s41429-021-00473-8