Journal of the Korean Society of Manufacturing Process Engineers (한국기계가공학회지)

The Korean Society of Manufacturing Process Engineers (한국기계가공학회)
권호 표지
DOI QR코드

DOI QR Code

Multifunctional Transdermal Diffusion Test System

다기능 경피 확산 테스트 시스템 설계 및 제작

  • Gao, Mengyan (Department of Electronic Information Engineering., Yanbian University) ;
  • Jin, Hu (Ganting Network Technology Co., Ltd.) ;
  • Piao, Xiang Fan (Department of Electronic Information Engineering., Yanbian University)
  • 고멍얀 (연변대학교 공학원 전자정보학과) ;
  • 김호 (간팅인너넷기술) ;
  • 박상범 (연변대학교 공학원 전자정보학과)
  • Received : 2020.07.04
  • Accepted : 2020.07.19
  • Published : 2020.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

The diffusion cell method is the main technique employed for the in vitro diffusion test of transdermal drug delivery preparations. Most existing transdermal diffusion devices use a water bath heating structure and direct current motor magnetic stirrer. However, these devices are confronted with problems, such as large volume, incompatible vertical and horizontal diffusion cells, few diffusion cell sets, and poor reliability. To overcome these deficiencies, the system adopts a dry heating method and uses a rotating magnetic field generated by the electromagnetic stirrer to drive the magnetic stirrer. Accordingly, the resulting device is characterized by a simple structure and small volume, convenient operation, compatible vertical and horizontal diffusion cells, and numerous diffusion cell sets. The reliability and practicability of the system is verified by the in vitro percutaneous permeability test of the bisoprolol patch.

Keywords

References

  1. Li, Y. W., Liu, W. Z., & Lin, L., "Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model", Journal of the Neuropharmacology, Vol. 63, No. 11, pp. 255-263, 2016.
  2. Tian, L, Zhang, S, Lin, H. Q., Deng, H., & Zhang, X. L., "Research progress of transdermal diffusion test methods for transdermal drug delivery", Chinese Pharmacy, Vol. 23, No. 29 ,pp. 2761-2764, 2012.
  3. Wang, Y. Z, Ren, T. C., & Sun, X. M., "Advances in research on oil-water partition coefficient and percutaneous absorption rate constant of Lappaconitine", Journal of Shandong University of Traditional Chinese Medicine, Vol. 12, No. 02, pp.155-156, 2006.
  4. Li, Z. H., Sun, H. Y., Wang, H., Xu, P., & Hou, H. M., "Improvement of in vitro diffusion cell in percutaneous drug administration research", China Pharmaceutical Industry Journal, No. 07, pp. 309-310+333. 1995.
  5. Keshary, P. R., Chien, Y. W., "Mechanism soft transdermal controlled nitroglycerin administration development of finite dosing skin permeation system", Vol. 10, No. 06, pp. 883, 2014. https://doi.org/10.3109/03639048409040788
  6. Hong Jing Technology Co. Ltd. IAP15W413AS Microcontroller Devices Using Manual.
  7. BHATT, J., SUBBAIAH, G., &KAMBLI, S., " high throughput and sensitive liquid chromatography-tandem mass spectrometry method for the estimation of bisoprolol in human plasma using multiplexing technique" Journal of Chromatography B, Vol. 852, No. 01, pp. 382-428, 2017.
  8. Hefnawy, M. M., Sultan, M. A., Al-Shehri, M. M., "Chemical and Pharmaceutical Bulletin", Public We lfare Corporation Japan Pharmaceutical Society, Vol. 55, No. 08, pp. 816_2, 2019.
  9. Wang, H. Y., Fan, P. F., Zhang, D., "Ultrasound mediated transdermal drug delivery of fluorescent nanoparticles and hyaluronic acid into porcine skin in vitro", Chinese Physics B, Vol. 25, No. 12, pp. 102-109, 2016.
  10. Zhang, J., Du, H. G., Zhang, E. H., Ke, G. M., Wang, L. "Study on the structure characterization a nd transdermal properties of bisoprolol", Journal of Beijing University of Chemical Technology, Vol. 04, No. 2, pp. 65-69, 2016.
  11. Zhang, X. H., Ouyang, J., & Baeyens, W. R. G., "Enantiomeric separation of -blockers by HPLC u sing(R)-1-naphthylglycine and 3,5-dinitroben-zoic acid as chiral stationary phase", Journal of Pharmaceutical and Biomedical Analysis, Vol. 23, No. 14, pp. 44, 2013.