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An Overview on Naps in Sleep Medicine

낮잠의 수면 의학적 개관

  • Cyn, Jaegong (Yong-In Mental Hospital, Yong-In Mental Psychiatric Research Institute)
  • 신재공 (용인정신병원, 용인정신의학연구소)
  • Received : 2020.12.02
  • Accepted : 2020.12.25
  • Published : 2020.12.31

Abstract

Napping is a natural and universal phenomenon. There are some differences depending on the age, but they are common throughout life. As research on naps in sleep medicine has recently increased, negative perceptions about naps are gradually decreasing with development of new and positive perspectives. First, naps relieve fatigue and sleepiness and increase arousal, improving cognitive abilities. Even in the process of memory consolidation, which allows retention of learned memory content, a period of short daytime sleep shows the same results as nocturnal sleep. In addition, evidence of the contribution of sleep to emotional regulation is increasing. The role of the nap has been extended recently to areas associated with immunity and pain. However, naps can disturb sleep at night. There are also concerns that habitual naps in old age are linked to cardiovascular risk and increased mortality. Various aspects and values of naps are being gradually unveiled. However, compared to that of night sleep, research on naps is insufficient, and more research on naps is required.

Keywords

References

  1. Achermann P, Werth E, Dijk DJ, Borbely AA. Time course of sleep inertia after nighttime and daytime sleep episodes. Arch Ital Biol 1995;134:109-119.
  2. Alger SE, Lau H, Fishbein W. Delayed onset of a daytime nap facilitates retention of declarative memory. PLoS One 2010;5:e12131. https://doi.org/10.1371/journal.pone.0012131
  3. Alger SE, Lau H, Fishbein W. Slow wave sleep during a daytime nap is necessary for protection from subsequent interference and long-term retention. Neurobiol Learn Mem 2012;98:188-196. https://doi.org/10.1016/j.nlm.2012.06.003
  4. Alsaadi SM, McAuley JH, Hush JM, Lo S, Bartlett DJ, Grunstein RR, et al. The bidirectional relationship between pain intensity and sleep disturbance/quality in patients with low back pain. Clin J Pain 2014;30:755-765. https://doi.org/10.1097/ajp.0000000000000055
  5. Artner J, Cakir B, Spiekermann JA, Kurz S, Leucht F, Reichel H, et al. Prevalence of sleep deprivation in patients with chronic neck and back pain: a retrospective evaluation of 1016 patients. J Pain Res 2013;6:1-6. https://doi.org/10.2147/JPR.S36386
  6. Auvinen JP, Tammelin TH, Taimela SP, Zitting PJ, Jarvelin MR, Taanila AM, et al. Is insufficient quantity and quality of sleep a risk factor for neck, shoulder and low back pain? A longitudinal study among adolescents. Eur Spine J 2010;19:641-649. https://doi.org/10.1007/s00586-009-1215-2
  7. Backhaus J, Junghanns K. Daytime naps improve procedural motor memory. Sleep Med 2006;7:508-512. https://doi.org/10.1016/j.sleep.2006.04.002
  8. Baran B, Mantua J, Spencer RM. Age-related changes in the sleep-dependent reorganization of declarative memories. J Cogn Neurosci 2016;28:792-802. https://doi.org/10.1162/jocn_a_00938
  9. Baran B, Pace-Schott EF, Ericson C, Spencer RM. Processing of emotional reactivity and emotional memory over sleep. J Neurosci 2012;32:1035-1042. https://doi.org/10.1523/JNEUROSCI.2532-11.2012
  10. Barone TL. Is the siesta an adaptation to disease?: A cross-cultural examination. Hum Nat 2000;11:233-258. https://doi.org/10.1007/s12110-000-1012-4
  11. Barrett TR, Ekstrand BR. Effect of sleep on memory. 3. Controlling for time-of-day effects. J Exp Psychol 1972;96:321-327. https://doi.org/10.1037/h0033625
  12. Batejat DM, Lagarde DP. Naps and modafinil as countermeasures for the effects of sleep deprivation on cognitive performance. Aviat Space Environ Med 1999;70:493-498.
  13. Benca RM, Obermeyer WH, Thisted RA, Gillin JC. Sleep and psychiatric disorders. A meta-analysis. Arch Gen Psychiatry 1992; 49:651-668; discussion 669-670. https://doi.org/10.1001/archpsyc.1992.01820080059010
  14. Berger RH, Miller AL, Seifer R, Cares SR, LeBourgeois MK. Acute sleep restriction effects on emotion responses in 30- to 36-month-old children. J Sleep Res 2012;21:235-246. https://doi.org/10.1111/j.1365-2869.2011.00962.x
  15. Bhat RY, Hannam S, Pressler R, Rafferty GF, Peacock JL, Greenough A. Effect of prone and supine position on sleep, apneas, and arousal in preterm infants. Pediatrics 2006;118:101-107. https://doi.org/10.1542/peds.2005-1873
  16. Bonnet MH. The effect of varying prophylactic naps on performance, alertness and mood throughout a 52-hour continuous operation. Sleep 1991;14:307-315. https://doi.org/10.1093/sleep/14.4.307
  17. Bonnet MH, Gomez S, Wirth O, Arand DL. The use of caffeine versus prophylactic naps in sustained performance. Sleep 1995;18: 97-104. https://doi.org/10.1093/sleep/18.2.97
  18. Brooks A, Lack L. A brief afternoon nap following nocturnal sleep restriction: which nap duration is most recuperative? Sleep 2006; 29:831-840. https://doi.org/10.1093/sleep/29.6.831
  19. Bursztyn M, Ginsberg G, Hammerman-Rozenberg R, Stessman J. The siesta in the elderly: risk factor for mortality? Arch Intern Med 1999;159:1582-1586. https://doi.org/10.1001/archinte.159.14.1582
  20. Buysse DJ, Browman KE, Monk TH, Reynolds CF, 3rd, Fasiczka AL, Kupfer DJ. Napping and 24-hour sleep/wake patterns in healthy elderly and young adults. J Am Geriatr Soc 1992;40: 779-786. https://doi.org/10.1111/j.1532-5415.1992.tb01849.x
  21. Cajochen C, Knoblauch V, Wirz-Justice A, Krauchi K, Graw P, Wallach D. Circadian modulation of sequence learning under high and low sleep pressure conditions. Behav Brain Res 2004; 151:167-176. https://doi.org/10.1016/j.bbr.2003.08.013
  22. Campbell SS, Murphy PJ, Stauble TN. Effects of a nap on nighttime sleep and waking function in older subjects. J Am Geriatr Soc 2005;53:48-53. https://doi.org/10.1111/j.1532-5415.2005.53009.x
  23. Campos H, Siles X. Siesta and the risk of coronary heart disease: results from a population-based, case-control study in Costa Rica. Int J Epidemiol 2000;29:429-437. https://doi.org/10.1093/ije/29.3.429
  24. Cappuccio FP, Cooper D, D'Elia L, Strazzullo P, Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J 2011;32: 1484-1492. https://doi.org/10.1093/eurheartj/ehr007
  25. Cappuccio FP, D'Elia L, Strazzullo P, Miller MA. Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 2010;33:414-420. https://doi.org/10.2337/dc09-1124
  26. Cremone A, Kurdziel LBF, Fraticelli-Torres A, McDermott JM, Spencer RMC. Napping reduces emotional attention bias during early childhood. Dev Sci 2017;20:10.1111/desc12411.
  27. Debas K, Carrier J, Orban P, Barakat M, Lungu O, Vandewalle G, et al. Brain plasticity related to the consolidation of motor sequence learning and motor adaptation. Proc Natl Acad Sci U S A 2010;107:17839-17844. https://doi.org/10.1073/pnas.1013176107
  28. Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci 2010;11:114-126. https://doi.org/10.1038/nrn2762
  29. Dinges DF. Napping patterns and effects in human adults. Sleep and alertness: chronobiological, behavioural, and medical aspects of napping. Dinges DF, Broughton RJ. New York, NY, Raven Press;1989. p.171-204. .
  30. Dinges DF, Orne MT, Whitehouse WG, Orne EC. Temporal placement of a nap for alertness: contributions of circadian phase and prior wakefulness. Sleep 1987;10:313-329.
  31. Doyon J, Penhune V, Ungerleider LG. Distinct contribution of the cortico-striatal and cortico-cerebellar systems to motor skill learning. Neuropsychologia 2003;41:252-262. https://doi.org/10.1016/S0028-3932(02)00158-6
  32. Edwards RR, Almeida DM, Klick B, Haythornthwaite JA, Smith MT. Duration of sleep contributes to next-day pain report in the general population. Pain 2008;137:202-207. https://doi.org/10.1016/j.pain.2008.01.025
  33. Faraut B, Andrillon T, Vecchierini MF, Leger D. Napping: A public health issue. From epidemiological to laboratory studies. Sleep Med Rev 2017;35:85-100. https://doi.org/10.1016/j.smrv.2016.09.002
  34. Faraut B, Boudjeltia KZ, Dyzma M, Rousseau A, David E, Stenuit P, et al. Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction. Brain Behav Immun 2011;25:16-24. https://doi.org/10.1016/j.bbi.2010.08.001
  35. Faraut B, Leger D, Medkour T, Dubois A, Bayon V, Chennaoui M, et al. Napping reverses increased pain sensitivity due to sleep restriction. PLoS One 2015;10:e0117425. https://doi.org/10.1371/journal.pone.0117425
  36. Faraut B, Nakib S, Drogou C, Elbaz M, Sauvet F, De Bandt JP, et al. Napping reverses the salivary interleukin-6 and urinary norepinephrine changes induced by sleep restriction. J Clin Endocrinol Metab 2015;100:E416-E426. https://doi.org/10.1210/jc.2014-2566
  37. Faraut B, Touchette E, Gamble H, Royant-Parola S, Safar ME, Varsat B, et al. Short sleep duration and increased risk of hypertension: a primary care medicine investigation. J Hypertens 2012; 30:1354-1363. https://doi.org/10.1097/hjh.0b013e32835465e5
  38. Feinberg I, Maloney T, March JD. Precise conservation of NREM period 1 (NREMP1) delta across naps and nocturnal sleep: implications for REM latency and NREM/REM alternation. Sleep 1992;15:400-403. https://doi.org/10.1093/sleep/15.5.400
  39. Ferrie JE, Shipley MJ, Cappuccio FP, Brunner E, Miller MA, Kumari M, et al. A prospective study of change in sleep duration: associations with mortality in the Whitehall II cohort. Sleep 2007;30:1659-1666. https://doi.org/10.1093/sleep/30.12.1659
  40. Ficca G, Axelsson J, Mollicone DJ, Muto V, Vitiello MV. Naps, cognition and performance. Sleep Med Rev 2010;14:249-258. https://doi.org/10.1016/j.smrv.2009.09.005
  41. Ficca G, Lombardo P, Rossi L, Salzarulo P. Morning recall of verbal material depends on prior sleep organization. Behav Brain Res 2000;112:159-163. https://doi.org/10.1016/S0166-4328(00)00177-7
  42. Ficca G, Salzarulo P. What in sleep is for memory. Sleep Med 2004; 5:225-230. https://doi.org/10.1016/j.sleep.2004.01.018
  43. Foley DJ, Vitiello MV, Bliwise DL, Ancoli-Israel S, Monjan AA, Walsh JK. Frequent napping is associated with excessive daytime sleepiness, depression, pain, and nocturia in older adults: findings from the National Sleep Foundation '2003 Sleep in America' Poll. Am J Geriatr Psychiatry 2007;15:344-350. https://doi.org/10.1097/01.JGP.0000249385.50101.67
  44. Gais S, Born J. Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation. Proc Natl Acad Sci U S A 2004;101:2140-2144. https://doi.org/10.1073/pnas.0305404101
  45. Groch S, Wilhelm I, Diekelmann S, Sayk F, Gais S, Born J. Contribution of norepinephrine to emotional memory consolidation during sleep. Psychoneuroendocrinology 2011;36:1342-1350. https://doi.org/10.1016/j.psyneuen.2011.03.006
  46. Gujar N, McDonald SA, Nishida M, Walker MP. A role for REM sleep in recalibrating the sensitivity of the human brain to specific emotions. Cereb Cortex 2011;21:115-123. https://doi.org/10.1093/cercor/bhq064
  47. Hasselmo ME. Neuromodulation: acetylcholine and memory consolidation. Trends Cogn Sci 1999;3:351-359. https://doi.org/10.1016/S1364-6613(99)01365-0
  48. Hays JC, Blazer DG, Foley DJ. Risk of napping: excessive daytime sleepiness and mortality in an older community population. J Am Geriatr Soc 1996;44:693-698. https://doi.org/10.1111/j.1532-5415.1996.tb01834.x
  49. Iglowstein I, Jenni OG, Molinari L, Largo RH. Sleep duration from infancy to adolescence: reference values and generational trends. Pediatrics 2003;111:302-307. https://doi.org/10.1542/peds.111.2.302
  50. Imeri L, Opp MR. How (and why) the immune system makes us sleep. Nat Rev Neurosci 2009;10:199-210. https://doi.org/10.1038/nrn2576
  51. Jewett ME, Wyatt JK, Ritz-De Cecco A, Khalsa SB, Dijk DJ, Czeisler CA. Time course of sleep inertia dissipation in human performance and alertness. J Sleep Res 1999;8:1-8.
  52. Kitamura S, Enomoto M, Kamei Y, Inada N, Moriwaki A, Kamio Y, et al. Association between delayed bedtime and sleep-related problems among community-dwelling 2-year-old children in Japan. J Physiol Anthropol 2015;34:12. https://doi.org/10.1186/s40101-015-0050-x
  53. Korman M, Doyon J, Doljansky J, Carrier J, Dagan Y, Karni A. Daytime sleep condenses the time course of motor memory consolidation. Nat Neurosci 2007;10:1206-1213. https://doi.org/10.1038/nn1959
  54. Kubo T, Takeyama H, Matsumoto S, Ebara T, Murata K, Tachi N, et al. Impact of nap length, nap timing and sleep quality on sustaining early morning performance. Ind Health 2007;45:552-263. https://doi.org/10.2486/indhealth.45.552
  55. Kurdziel L, Duclos K, Spencer RM. Sleep spindles in midday naps enhance learning in preschool children. Proc Natl Acad Sci U S A 2013;110:17267-17272. https://doi.org/10.1073/pnas.1306418110
  56. Lahl O, Wispel C, Willigens B, Pietrowsky R. An ultra short episode of sleep is sufficient to promote declarative memory performance. J Sleep Res 2008;17:3-10. https://doi.org/10.1111/j.1365-2869.2008.00622.x
  57. Lavie P. Ultrashort sleep-waking schedule. III. 'Gates' and 'forbidden zones' for sleep. Electroencephalogr Clin Neurophysiol 1986;63:414-425. https://doi.org/10.1016/0013-4694(86)90123-9
  58. Louis J, Cannard C, Bastuji H, Challamel MJ. Sleep ontogenesis revisited: a longitudinal 24-hour home polygraphic study on 15 normal infants during the first two years of life. Sleep 1997;20: 323-333. https://doi.org/10.1093/sleep/20.5.323
  59. Lowden A, Holmback U, Akerstedt T, Forslund J, Lennernas M, Forslund A. Performance and sleepiness during a 24 h wake in constant conditions are affected by diet. Biol Psychol 2004;65: 251-263. https://doi.org/10.1016/S0301-0511(03)00114-5
  60. Lumley M, Roehrs T, Zorick F, Lamphere J, Roth T. The alerting effects of naps in sleep-deprived subjects. Psychophysiology 1986; 23:403-408. https://doi.org/10.1111/j.1469-8986.1986.tb00653.x
  61. Mallon L, Hetta J. A survey of sleep habits and sleeping difficulties in an elderly Swedish population. Ups J Med Sci 1997;102: 185-197. https://doi.org/10.3109/03009739709178940
  62. Maquet P, Laureys S, Peigneux P, Fuchs S, Petiau C, Phillips C, et al. Experience-dependent changes in cerebral activation during human REM sleep. Nat Neurosci 2000;3:831-836. https://doi.org/10.1038/77744
  63. McDevitt EA, Alaynick WA, Mednick SC. The effect of nap frequency on daytime sleep architecture. Physiol Behav 2012;107: 40-44. https://doi.org/10.1016/j.physbeh.2012.05.021
  64. Mednick S, Nakayama K, Stickgold R. Sleep-dependent learning: a nap is as good as a night. Nat Neurosci 2003;6:697-698. https://doi.org/10.1038/nn1078
  65. Mednick SC, Cai DJ, Kanady J, Drummond SP. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res 2008;193:79-86. https://doi.org/10.1016/j.bbr.2008.04.028
  66. Mednick SC, Nakayama K, Cantero JL, Atienza M, Levin AA, Pathak N, et al. The restorative effect of naps on perceptual deterioration. Nat Neurosci 2002;5:677-681. https://doi.org/10.1038/nn864
  67. Metz ME, Bunnell DE. Napping and sleep disturbances in the elderly. Fam Pract Res J 1990;10:47-56.
  68. Miller AL, Seifer R, Crossin R, Lebourgeois MK. Toddler's self-regulation strategies in a challenge context are nap-dependent. J Sleep Res 2015;24:279-287. https://doi.org/10.1111/jsr.12260
  69. Monk TH, Buysse DJ, Carrier J, Billy BD, Rose LR. Effects of afternoon "siesta" naps on sleep, alertness, performance, and circadian rhythms in the elderly. Sleep 2001;24:680-687. https://doi.org/10.1093/sleep/24.6.680
  70. Naitoh P, Angus RG. Napping and human functioning during prolonged work. sleep and alertness: chronobiological, behavioural, and medical aspects of napping. Dinges DF, Broughton RJ. New York, NY, Raven Press;1989. p.221-246.
  71. Naitoh P, Kelly T, Babkoff H. Sleep inertia: best time not to wake up? Chronobiol Int 1993;10:109-118. https://doi.org/10.1080/07420529309059699
  72. Naska A, Oikonomou E, Trichopoulou A, Psaltopoulou T, Trichopoulos D. Siesta in healthy adults and coronary mortality in the general population. Arch Intern Med 2007;167:296-301. https://doi.org/10.1001/archinte.167.3.296
  73. National Sleep Foundation. 2013 International Bedroom Poll. Available from: https://www.sleepfoundation.org/wp-content/up-loads/2018/10/RPT495a.pdf?x86379.
  74. Nesca M, Koulack D. Recognition memory, sleep and circadian rhythms. Can J Exp Psychol 1994;48:359-379. https://doi.org/10.1037/1196-1961.48.3.359
  75. Newman AB, Spiekerman CF, Enright P, Lefkowitz D, Manolio T, Reynolds CF, et al. Daytime sleepiness predicts mortality and cardiovascular disease in older adults. The Cardiovascular Health Study Research Group. J Am Geriatr Soc 2000;48:115-123. https://doi.org/10.1111/j.1532-5415.2000.tb03901.x
  76. Nishida M, Walker MP. Daytime naps, motor memory consolidation and regionally specific sleep spindles. PLoS One 2007;2: e341. https://doi.org/10.1371/journal.pone.0000341
  77. O'Donoghue GM, Fox N, Heneghan C, Hurley DA. Objective and subjective assessment of sleep in chronic low back pain patients compared with healthy age and gender matched controls: a pilot study. BMC Musculoskelet Disord 2009;10:122. https://doi.org/10.1186/1471-2474-10-122
  78. Ohayon MM, Zulley J. Prevalence of naps in the general population. Sleep Hypn 1999;1:88-97.
  79. Olivadoti MD, Opp MR. Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice. Neuroscience 2008;153:338-348. https://doi.org/10.1016/j.neuroscience.2008.02.008
  80. Pace-Schott EF, Shepherd E, Spencer RM, Marcello M, Tucker M, Propper RE, et al. Napping promotes inter-session habituation to emotional stimuli. Neurobiol Learn Mem 2011;95:24-36. https://doi.org/10.1016/j.nlm.2010.10.006
  81. Palmer CA, Alfano CA. Sleep and emotion regulation: an organizing, integrative review. Sleep Med Rev 2017;31:6-16. https://doi.org/10.1016/j.smrv.2015.12.006
  82. Picarsic JL, Glynn NW, Taylor CA, Katula JA, Goldman SE, Studenski SA, et al. Self-reported napping and duration and quality of sleep in the lifestyle interventions and independence for elders pilot study. J Am Geriatr Soc 2008;56:1674-1680. https://doi.org/10.1111/j.1532-5415.2008.01838.x
  83. Rawlins JN. Associations across time: The hippocampus as a temporary memory store. Behav Brain Sci 1985;8: 479-528. https://doi.org/10.1017/S0140525X00001291
  84. Redwine L, Dang J, Irwin M. Cellular adhesion molecule expression, nocturnal sleep, and partial night sleep deprivation. Brain Behav Immun 2004;18:333-340. https://doi.org/10.1016/j.bbi.2004.01.001
  85. Reyner LA, Horne JA. Suppression of sleepiness in drivers: combination of caffeine with a short nap. Psychophysiology 1997;34: 721-725. https://doi.org/10.1111/j.1469-8986.1997.tb02148.x
  86. Roehrs T, Hyde M, Blaisdell B, Greenwald M, Roth T. Sleep loss and REM sleep loss are hyperalgesic. Sleep 2006;29:145-151. https://doi.org/10.1093/sleep/29.2.145
  87. Roehrs TA, Harris E, Randall S, Roth T. Pain sensitivity and recovery from mild chronic sleep loss. Sleep 2012;35:1667-1672.
  88. Schabus M, Hodlmoser K, Pecherstorfer T, Klosch G. Influence of midday naps on declarative memory performance and motivation. Somnologie 2005;9:148-153. https://doi.org/10.1111/j.1439-054X.2005.00054.x
  89. Schoen LS, Badia P. Facilitated recall following REM and NREM naps. Psychophysiology 1984;21:299-306. https://doi.org/10.1111/j.1469-8986.1984.tb02937.x
  90. Schonauer M, Geisler T, Gais S. Strengthening procedural memories by reactivation in sleep. J Cogn Neurosci 2014;26:143-153. https://doi.org/10.1162/jocn_a_00471
  91. Simpson N, Dinges DF. Sleep and inflammation. Nutr Rev 2007; 65(12 Pt 2):S244-S252. https://doi.org/10.1111/j.1753-4887.2007.tb00371.x
  92. Smith MT, Haythornthwaite JA. How do sleep disturbance and chronic pain inter-relate? Insights from the longitudinal and cognitive-behavioral clinical trials literature. Sleep Med Rev 2004;8:119-132. https://doi.org/10.1016/S1087-0792(03)00044-3
  93. Stepanski EJ, Wyatt JK. Use of sleep hygiene in the treatment of insomnia. Sleep Med Rev 2003;7:215-225. https://doi.org/10.1053/smrv.2001.0246
  94. Stickgold R. Sleep-dependent memory consolidation. Nature 2005; 437:1272-1278. https://doi.org/10.1038/nature04286
  95. Stickgold R, James L, Hobson JA. Visual discrimination learning requires sleep after training. Nat Neurosci 2000;3:1237-1238. https://doi.org/10.1038/81756
  96. Takahashi M, Iwakiri K, Sotoyama M, Hirata M, Hisanaga N. Musculoskeletal pain and night-shift naps in nursing home care workers. Occup Med (Lond) 2009;59:197-200. https://doi.org/10.1093/occmed/kqp029
  97. Tassi P, Muzet A. Sleep inertia. Sleep Med Rev 2000;4:341-353. https://doi.org/10.1053/smrv.2000.0098
  98. Thorleifsdottir B, Bjornsson JK, Benediktsdottir B, Gislason T, Kristbjarnarson H. Sleep and sleep habits from childhood to young adulthood over a 10-year period. J Psychosom Res 2002;53:529-537. https://doi.org/10.1016/S0022-3999(02)00444-0
  99. Tiede W, Magerl W, Baumgartner U, Durrer B, Ehlert U, Treede RD. Sleep restriction attenuates amplitudes and attentional modulation of pain-related evoked potentials, but augments pain ratings in healthy volunteers. Pain 2010;148:36-42. https://doi.org/10.1016/j.pain.2009.08.029
  100. Tietzel AJ, Lack LC. The short-term benefits of brief and long naps following nocturnal sleep restriction. Sleep 2001;24:293-300. https://doi.org/10.1093/sleep/24.3.293
  101. Tietzel AJ, Lack LC. The recuperative value of brief and ultra-brief naps on alertness and cognitive performance. J Sleep Res 2002; 11:213-218. https://doi.org/10.1046/j.1365-2869.2002.00299.x
  102. Tononi G, Cirelli C. Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration. Neuron 2014;81:12-34. https://doi.org/10.1016/j.neuron.2013.12.025
  103. Trichopoulos D, Tzonou A, Christopoulos C, Havatzoglou S, Trichopoulou A. Does a siesta protect from coronary heart disease? Lancet 1987;2:269-270. https://doi.org/10.1016/S0140-6736(02)93389-1
  104. Tucker MA, Fishbein W. Enhancement of declarative memory performance following a daytime nap is contingent on strength of initial task acquisition. Sleep 2008;31:197-203. https://doi.org/10.1093/sleep/31.2.197
  105. Tucker MA, Hirota Y, Wamsley EJ, Lau H, Chaklader A, Fishbein W. A daytime nap containing solely non-REM sleep enhances declarative but not procedural memory. Neurobiol Learn Mem 2006;86:241-247. https://doi.org/10.1016/j.nlm.2006.03.005
  106. Weissbluth M. Naps in children: 6 months-7 years. Sleep 1995;18: 82-87. https://doi.org/10.1093/sleep/18.2.82
  107. Wilson MA, McNaughton BL. Reactivation of hippocampal ensemble memories during sleep. Science 1994;265:676-679. https://doi.org/10.1126/science.8036517
  108. Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, et al. Sleep drives metabolite clearance from the adult brain. Science 2013;342:373-377. https://doi.org/10.1126/science.1241224
  109. Yamada T, Hara K, Shojima N, Yamauchi T, Kadowaki T. Daytime napping and the risk of cardiovascular disease and all-cause mortality: a prospective study and dose-response meta-analysis. Sleep 2015;38:1945-1953. https://doi.org/10.5665/sleep.5246
  110. Yoon IY, Kripke DF, Youngstedt SD, Elliott JA. Actigraphy suggests age-related differences in napping and nocturnal sleep. J Sleep Res 2003;12:87-93. https://doi.org/10.1046/j.1365-2869.2003.00345.x
  111. Zaregarizi M, Edwards B, George K, Harrison Y, Jones H, Atkinson G. Acute changes in cardiovascular function during the onset period of daytime sleep: comparison to lying awake and standing. J Appl Physiol (1985) 2007;103:1332-1338. https://doi.org/10.1152/japplphysiol.00474.2007
  112. Zhong G, Wang Y, Tao T, Ying J, Zhao Y. Daytime napping and mortality from all causes, cardiovascular disease, and cancer: a meta-analysis of prospective cohort studies. Sleep Med 2015; 16:811-819. https://doi.org/10.1016/j.sleep.2015.01.025