대한화장품학회지 (Journal of the Society of Cosmetic Scientists of Korea)

  • 제45권3호
  • /
  • Pages.217-224
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  • 2019
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  • 1226-2587(pISSN)
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  • 2288-9507(eISSN)
대한화장품학회 (Society of Cosmetic Scientists of Korea)
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네일 관련 제품들의 프탈레이트 분석에 관한 연구

A Study on Phthalate Analysis of Nail Related Products

  • 박신희 (경기도보건환경연구원 의약품분석팀) ;
  • 송서현 (경기도보건환경연구원 의약품분석팀) ;
  • 김현주 (경기도보건환경연구원 의약품분석팀) ;
  • 조윤식 (경기도보건환경연구원 의약품분석팀) ;
  • 김애란 (경기도보건환경연구원 의약품분석팀) ;
  • 김범호 (경기도보건환경연구원 의약품분석팀) ;
  • 홍미연 (경기도보건환경연구원 의약품분석팀) ;
  • 박상현 (경기도보건환경연구원 의약품분석팀) ;
  • 윤미혜 (경기도보건환경연구원 의약품분석팀)
  • Rark, Sin-Hee (Pharmaceutical Analaysis Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Song, Seo-Hyeon (Pharmaceutical Analaysis Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Kim, Hyun-Joo (Pharmaceutical Analaysis Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Cho, Youn-Sik (Pharmaceutical Analaysis Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Kim, Ae-Ran (Pharmaceutical Analaysis Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Kim, Beom-Ho (Pharmaceutical Analaysis Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Hong, Mi-Yeun (Pharmaceutical Analaysis Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Park, Sang-Hyun (Pharmaceutical Analaysis Team, Gyeonggi-Do Institute of Health and Environment) ;
  • Yoon, Mi-Hye (Pharmaceutical Analaysis Team, Gyeonggi-Do Institute of Health and Environment)
  • 투고 : 2019.05.09
  • 심사 : 2019.08.13
  • 발행 : 2019.09.30
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초록

프탈레이트는 내분비계 교란 물질로서 성호르몬과 구조가 유사하여 주로 생식독성과 발달독성을 나타낸다. 이번 연구에서는 우리나라 화장품규제 물질인 3종 프탈레이트 이외 어린이제품 안전공통기준, EU 화장품 기준(EC No. 1223/2009) 등에서 규제하고 있는 프탈레이트 종류를 추가하여 총 11종 프탈레이트에 관하여 분석을 실시하였다. GC-MS/MS를 이용하여 분석조건을 설정하였고 분석방법에 대한 유효성 검증 결과 특이성, 직선성, 회수율, 정밀성, 정량한계 등을 만족하였다. 유효성이 검증된 시험방법을 이용하여 네일 화장품 및 네일 관련 제품 82건을 대상으로 분석을 실시하였다. 네일 폴리시에서는 DBP, BBP, DEHP, DPP, DIBP, DIDP 등 6종의 프탈레이트가 $1.0{\sim}59.8{\mu}g/g$의 농도로 검출되었으나 우리나라 화장품기준에 적합하였다. 인조손톱에서는 DIBP, DBP 2종에서 $1.1{\sim}2.6{\mu}g/g$, 글루에서 DBP, DEHP 2종 $1.4{\sim}2.5{\mu}g/g$, 스티커 DIBP, DBP, DEHP 3종에서 $2.5{\sim}33.3{\mu}g/g$ 의 결과가 나왔고 '어린이제품 공통안전기준'을 적용시 모두 적합하였다. DIBP는 우리나라에는 규제물질이 아니지만 DBP (86.6%), DEHP (63.4%)에 이어 14.6%의 검출률을 나타내었다. 현재 우리나라 기준으로는 네일제품이 프탈레이트에 대해 안전하다고 판단되지만 비규제물질에 대한 지속적인 감시와 연구도 필요할 것으로 사료된다.

Phthalates, endocrine disrupting chemicals, are similar in structure to sex hormones and mainly show reproductive toxicity and developmental toxicity. In this study, we analyzed 11 phthalates, including 3 kinds of phthalates prohibited in cosmetic use and 8 kinds of phthalates regulated in 'Common standards for children's products safety' and EU cosmetic regulation (EC No. 1223/2009). The phthalate analysis was optimized using GC-MS/MS. In analytical method validation, this method was satisfied in specificity, linearity, recovery rate, accuracy and MQL. Therefore, we used this method to analyze 82 products of Nail cosmetics & polish. Although six phthalates such as DBP, BBP, DEHP, DPP, DIBP and DIDP were detected at concentrations of $1.0{\sim}59.8{\mu}g/g$g, they were suitable to Korean cosmetic standards. DIBP and DBP were detected at concentration of $1.1{\sim}2.6{\mu}g/g$ in artificial nail, DBP and DEHP were $1.4{\sim}2.5{\mu}g/g$ in glue for nails, and DIBP, DBP, and DEHP were $2.5{\sim}33.3{\mu}g/g$ in nail stickers. Although substances such as DBP and DEHP in artificial nail, Glue for nails, and nail stickers were detected, they were suitable to 'Common safety standards for children's products. DIBP is not a regulated substance in Korea but showed the third highest detection rate following DBP (84.6%) and DEHP (63.4%). The concentration of phthalates detected in nail products is considered to be safe in current standards but continuous monitoring and research about non-regulated substances are also needed to be considered.

키워드

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