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Paraneoplastic demyelination in the brain presenting as a clinically occult non-Hodgkin's lymphoma

  • Son, Hyoshin (Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Choi, Jongsuk (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Kim, Sung Un (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Park, Kyung Seok (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
  • Received : 2019.03.27
  • Accepted : 2019.07.02
  • Published : 2019.07.31

Abstract

Non-Hodgkin's lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy.

Keywords

References

  1. Armitage JO, Gascoyne RD, Lunning MA, Cavalli F. Non-Hodgkin lymphoma. Lancet 2017;390:298-310. https://doi.org/10.1016/S0140-6736(16)32407-2
  2. Rosenfeld MR, Dalmau J. Update on paraneoplastic neurologic disorders. Oncologist 2010;15:603-617. https://doi.org/10.1634/theoncologist.2010-0001
  3. Giometto B, Grisold W, Vitaliani R, Graus F, Honnorat J, Bertolini G, et al. Paraneoplastic neurologic syndrome in the PNS Euronetwork database: a European study from 20 centers. Arch Neurol 2010;67:330-335. https://doi.org/10.1001/archneurol.2009.341
  4. Graus F, Arino H, Dalmau J. Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas. Blood 2014;123:3230-3238. https://doi.org/10.1182/blood-2014-03-537506
  5. Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry 2004;75:1135-40. https://doi.org/10.1136/jnnp.2003.034447
  6. Glantz MJ, Biran H, Myers ME, Gockerman JP, Friedberg MH. The radiographic diagnosis and treatment of paraneoplastic central nervous system disease. Cancer 1994;73:168-175. https://doi.org/10.1002/1097-0142(19940101)73:1<168::AID-CNCR2820730129>3.0.CO;2-Z
  7. Wong K, Poon P, Berry K, Coppin C, Kostashuk E. Paraneoplastic demyelinating disorder in the brain of a patient with seminoma. J Comput Assist Tomogr 1998;22:136-138. https://doi.org/10.1097/00004728-199801000-00026
  8. Gonzales N, Jarboe E, Kleinschmidt-DeMasters BK, Bosque P. Acute multifocal CNS demyelination as first presentation of systemic malignancy. Neurology 2005;65:166. https://doi.org/10.1212/01.wnl.0000167610.43124.79
  9. Matsuhisa A, Toriihara A, Kubota K, Makino T, Mizusawa H, Shibuya H. Utility of F-18 FDG PET/CT in screening for paraneoplastic neurological syndromes. Clin Nucl Med 2012;37:39-43. https://doi.org/10.1097/RLU.0b013e3182393390
  10. Pavlidis N. The diagnostic and therapeutic management of leptomeningeal carcinomatosis. Ann Oncol 2004;15 Suppl 4:iv285-iv291. https://doi.org/10.1093/annonc/mdh941