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http://dx.doi.org/10.14253/acn.2019.21.2.108

Paraneoplastic demyelination in the brain presenting as a clinically occult non-Hodgkin's lymphoma  

Son, Hyoshin (Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine)
Choi, Jongsuk (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
Kim, Sung Un (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
Park, Kyung Seok (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
Publication Information
Annals of Clinical Neurophysiology / v.21, no.2, 2019 , pp. 108-112 More about this Journal
Abstract
Non-Hodgkin's lymphoma (NHL) may initially present with atypical neurological manifestations, including paraneoplastic neurological syndromes. Herein, we report the case showing an initial manifestation of systemic NHL with paraneoplastic demyelination in the brain that initially mimicked the symptoms of stroke, seizure, and brain tumor. A high index of suspicion and timely diagnostic workup is required to prevent diagnostic delay and commence proper management of the condition. In this situation, a whole-body FDG PET/CT could be useful to screen for occult malignancy.
Keywords
Paraneoplastic syndrome; Occult malignancy; Demyelinating diseases; Non-Hodgkin lymphoma; Diffuse large B-cell lymphoma;
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