DOI QR코드

DOI QR Code

A literature review on burning mouth syndrome

구강작열감 증후군에 대한 논문 고찰

  • Choi, Sung-Hyeon (Department of Conservative Dentistry, School of Dentistry, Chonnam National University) ;
  • Lee, Bin-Na (Department of Conservative Dentistry, School of Dentistry, Chonnam National University) ;
  • Lim, Hae-Soon (Department of Dentistry Education, School of Dentistry, Chonnam National University) ;
  • Oh, Won-Mann (Department of Conservative Dentistry, School of Dentistry, Chonnam National University) ;
  • Kim, Jae-Hyung (Department of Oral Medicine, School of Dentistry, Chonnam National University)
  • 최성현 (전남대학교 치과대학 보존학교실) ;
  • 이빈나 (전남대학교 치과대학 보존학교실) ;
  • 임회순 (전남대학교 치과대학 치의학교육학교실) ;
  • 오원만 (전남대학교 치과대학 보존학교실) ;
  • 김재형 (전남대학교 치과대학 구강내과학교실)
  • Received : 2019.07.01
  • Accepted : 2019.08.09
  • Published : 2019.09.30

Abstract

Burning mouth syndrome (BMS) is defined as the xerostomia, burning sensation and various discomfort of tongue and oral mucosa. BMS can occur in both men and women, but is more frequent in middle-aged menopausal women. Because exact cause can't be identified clearly and it is hard to make diagnosis in clinic, the purpose of the treatment have been to relieve symptoms. Etiology of BMS is divided into local, systemic, and psychological factors. ${\alpha}$-lipoic acid, clonazepam, supplemental therapy and cognitive behavior therapy can be prescribed for BMS. Nowdays, many experts focus attention on effect of combination therapy. It is necessary to solve the symptoms of the patients by combination of pharmacological approach and psychotherapy with cognitive behavior therapy considering the factors in various aspects.

구강작열감 증후군은 점막 이상 등의 임상소견이 없는 상태에서 혀 및 구강점막의 작열감과 구강건조감, 미각이상 등의 불편감을 호소하는 증상으로, 남녀 모두에서 나타날 수 있으나 중년의 폐경기 여성에서 빈발한다. 임상에서 진단이 쉽지 않고 명확한 원인을 밝히기 어려워 증상 경감을 치료목표로 해왔다. 병인은 국소적, 전신적 및 심리적 요인으로 나뉘고 치료는 ${\alpha}$-lipoic acid, clonazepam, 영양보충 등의 약물요법과 인지행동치료 등이 있으며 최근에는 단일 치료법보다는 복합요법의 높은 효과에 대해 관심이 모아지고 있다. 다각적인 면에서 원인요소를 고려하여 약물적 접근과 인지행동요법을 포함한 심리치료 병행으로 환자들의 증상을 경감해주는 것이 필요하다.

Keywords

References

  1. Grushka M. Clinical features of burning mouth syndrome. Oral Surg Oral Med Oral Pathol 1987;63:30-6. https://doi.org/10.1016/0030-4220(87)90336-7
  2. Koo J, Gambla C. Cutaneous sensory disorder. Dermatol Clin 1996;14:497-502. https://doi.org/10.1016/s0733-8635(05)70377-6
  3. Merskey H, Bogduk N. Classification of chronic pain, IASP Task Force on Taxonomy. 2nd ed. Seattle; International Association for the Study of Pain Press; 1994. p.209-14.
  4. Muzyka BC, De Rossi SS. A review of burning mouth syndrome. Cutis 1999;64:29-35.
  5. Scala A, Checchi L, Montevecchi M, Marini I, Giamberardino MA. Update on burning mouth syndrome: overview and patient management. Crit Rev Oral Biol Med 2003;14:275-91. https://doi.org/10.1177/154411130301400405
  6. Locker D, Grushka M. Prevalence of oral and facial pain and discomfort: preliminary results of a mail survey. Community Dent Oral Epidemiol 1987;15:169-72. https://doi.org/10.1111/j.1600-0528.1987.tb00508.x
  7. Klasser GD, Epstein JB. Oral burning and burning mouth syndrome. J Am Dent Assoc 2012;143:1317-9. https://doi.org/10.14219/jada.archive.2012.0093
  8. Bergdahl M, Bergdahl J. Burning mouth syndrome: prevalence and associated factors. J Oral Pathol Med 1999;28:350-4. https://doi.org/10.1111/j.1600-0714.1999.tb02052.x
  9. Jaaskelainen SK. Pathophysiology of primary burning mouth syndrome. Clin Neurophysiol 2012;123:71-7. https://doi.org/10.1016/j.clinph.2011.07.054
  10. Lamey PJ, Lamb AB. Prospective study of aetiological factors in burning mouth syndrome. Br Med J (Clin Res Ed) 1988;296:1243-6. https://doi.org/10.1136/bmj.296.6631.1243
  11. Chung JW, Kim JH, Kim HD, Kho HS, Kim YK, Chung SC. Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 2004;112:164-70. https://doi.org/10.1016/j.pain.2004.08.014
  12. Femiano F, Gombos F, Esposito V, Nunziata M, Scully C. Burning mouth syndrome (BMS): evaluation of thyroid and taste. Med Oral Patol Oral Cir Bucal 2006;11:E22-5.
  13. Savage NW, Boras VV, Barker K. Burning mouth syndrome: clinical presentation, diagnosis and treatment. Australas J Dermatol 2006;47:77-81. https://doi.org/10.1111/j.1440-0960.2006.00236.x
  14. Nagler RM, Hershkovich O. Sialochemical and gustatory analysis in patients with oral sensory complaints. J Pain 2004;5:56-63. https://doi.org/10.1016/j.jpain.2003.09.002
  15. Femiano F, Lanza A, Buonaiuto C, Gombos F, Nunziata M, Cuccurullo L, Cirillo N. Burning mouth syndrome and burning mouth in hypothyroidism: proposal for a diagnostic and therapeutic protocol. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:e22-7.
  16. Brufau-Redondo C, Martin-Brufau R, Corbalan-Velez R, de Concepcion-Salesa A. Burning mouth syndrome. Actas DermoSifiliogr 2008;99:431-40. https://doi.org/10.1016/S0001-7310(08)74714-8
  17. Basker RM, Sturdee DW, Davenport JC. Patients with burning mouth. A clinical investigation of causative factors, including the climacteric and diabetes. Br Dent J 1978;145:9-16. https://doi.org/10.1038/sj.bdj.4804107
  18. Tourne LP, Fricton JR. Burning mouth syndrome. Critical review and proposed clinical management. Oral Surg Oral Med Oral Pathol 1992;74:158-67. https://doi.org/10.1016/0030-4220(92)90376-2
  19. Wardrop RW, Hailes J, Burger H, Reade PC. Oral discomfort at menopause. Oral Surg Oral Med Oral Pathol 1989;67:535-40. https://doi.org/10.1016/0030-4220(89)90269-7
  20. Gao J, Chen L, Zhou J, Peng J. A case-control study on etiological factors involved in patients with burning mouth syndrome. J Oral Pathol Med 2009;38:24-8. https://doi.org/10.1111/j.1600-0714.2008.00708.x
  21. Woda A, Dao T, Gremeau-Richard C. Steroid dysregulation and stomatodynia (burning mouth syndrome). J Orofac Pain 2009;23:202-10.
  22. Zakrzewska JM. Critical commentary 1: steroid dysregulation and stomatodynia (burning mouth syndrome). J Orofac Pain 2009;23:211-3.
  23. Lamey PJ, Hammond A, Allam BF, McIntosh WB. Vitamin status of patients with burning mouth syndrome and response to replacement therapy. Br Dent J 1986;160:81-4. https://doi.org/10.1038/sj.bdj.4805773
  24. Lin HP, Wang YP, Chen HM, Kuo YS, Lang MJ, Sun A. Significant association of hematinic deficiencies and high blood homocysteine levels with burning mouth syndrome. J Formos Med Assoc 2013;112:319-25. https://doi.org/10.1016/j.jfma.2012.02.022
  25. Rhodus NL, Fricton J, Carlson P, Messner R. Oral symptoms associated with fibromyalgia syndrome. J Rheumatol 2003;30:1841-5.
  26. Maina G, Albert U, Gandolfo S, Vitalucci A, Bogetto F. Personality disorders in patients with burning mouth syndrome. J Pers Disord 2005;19:84-93. https://doi.org/10.1521/pedi.19.1.84.62182
  27. Huang W, Rothe MJ, Grant-Kels JM. The burning mouth syndrome. J Am Acad Dermatol 1996;34:91-8. https://doi.org/10.1016/S0190-9622(96)90840-3
  28. Lamey PJ, Freeman R, Eddie SA, Pankhurst C, Rees T. Vulnerability and presenting symptoms in burning mouth syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:48-54. https://doi.org/10.1016/j.tripleo.2004.01.021
  29. Amenabar JM, Pawlowski J, Hilgert JB, Hugo FN, Bandeira D, Lhuller F, Lopez de Souza MA. Anxiety and salivary cortisol levels in patients with burning mouth syndrome: case-control study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:460-5. https://doi.org/10.1016/j.tripleo.2007.10.002
  30. Coculescu EC, Radu A, Coculescu BI. Burning mouth syndrome: a review on diagnosis and treatment. J Med Life 2014;7:512-5.
  31. Aravindhan R, Vidyalakshmi S, Kumar MS, Satheesh C, Balasubramanium AM, Prasad VS. Burning mouth syndrome: A review on its diagnostic and therapeutic approach. J Pharm Bioallied Sci 2014;6:S21-5. https://doi.org/10.4103/0975-7406.137255
  32. Grushka M, Epstein JB, Gorsky M. Burning mouth syndrome: differential diagnosis. Dermatol Ther 2002;15:287-91. https://doi.org/10.1046/j.1529-8019.2002.01535.x
  33. Epstein JB, Marcoe JH. Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol 1994;77:135-40. https://doi.org/10.1016/0030-4220(94)90275-5
  34. Gremeau-Richard C, Woda A, Navez ML, Attal N, Bouhassira D, Gagnieu MC, Laluque JF, Picard P, Pionchon P, Tubert S. Topical clonazepam in stomatodynia: a randomised placebo-controlled study. Pain 2004;108:51-7. https://doi.org/10.1016/j.pain.2003.12.002
  35. Lopez-Jornet P, Camacho-Alonso F, Molino-Pagan D. Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. J Oral Pathol Med 2013;42:295-301. https://doi.org/10.1111/jop.12002
  36. Mancuso G, Berdondini RM. Simultaneous occurrence of dysaesthetic peno/scroto-dynia and stomatodynia. Int J STD AIDS 2005;16:830-1. https://doi.org/10.1258/095646205774988154
  37. Maina G, Vitalucci A, Gandolfo S, Bogetto F. Comparative efficacy of SSRIs and amisulpride in burning mouth syndrome: a single-blind study. J Clin Psychiatry 2002;63:38-43. https://doi.org/10.4088/JCP.v63n0108
  38. Culhane NS, Hodle AD. Burning mouth syndrome after taking clonazepam. Ann Pharmacother 2001;35:874-6. https://doi.org/10.1345/aph.1Z434
  39. Femiano F, Gombos F, Scully C. Burning mouth syndrome: the efficacy of lipoic acid on subgroups. J Eur Acad Dermatol Venereol 2004;18:676-8. https://doi.org/10.1111/j.1468-3083.2004.01049.x
  40. Sun A, Lin HP, Wang YP, Chen HM, Cheng SJ, Chiang CP. Significant reduction of serum homocysteine level and oral symptoms after different vitamin-supplement treatments in patients with burning mouth syndrome. J Oral Pathol Med 2013;42:474-9. https://doi.org/10.1111/jop.12043
  41. Cho GS, Han MW, Lee B, Roh JL, Choi SH, Cho KJ, Nam SY, Kim SY. Zinc deficiency may be a cause of burning mouth syndrome as zinc replacement therapy has therapeutic effects. J Oral Pathol Med 2010;39:722-7. https://doi.org/10.1111/j.1600-0714.2010.00914.x
  42. Forabosco A, Criscuolo M, Coukos G, Uccelli E, Weinstein R, Spinato S, Botticelli A, Volpe A. Efficacy of hormone replacement therapy in postmenopausal women with oral discomfort. Oral Surg Oral Med Oral Pathol 1992;73:570-4. https://doi.org/10.1016/0030-4220(92)90100-5
  43. Amos K, Yeoh SC, Farah CS. Combined topical and systemic clonazepam therapy for the management of burning mouth syndrome: a retrospective pilot study. J Orofac Pain 2011;25:125-30.
  44. Bergdahl J, Anneroth G, Perris H. Cognitive therapy in the treatment of patients with resistant burning mouth syndrome: a controlled study. J Oral Pathol Med 1995;24:213-5. https://doi.org/10.1111/j.1600-0714.1995.tb01169.x