한국의학물리학회지:의학물리 (Progress in Medical Physics)

  • 제30권4호
  • /
  • Pages.112-119
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  • 2019
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  • 2508-4445(pISSN)
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  • 2508-4453(eISSN)
한국의학물리학회 (Korean Society of Medical Physics)
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Therapeutic Proton Beam Range Measurement with EBT3 Film and Comparison with Tool for Particle Simulation

  • Lee, Nuri (Department of Radiation Oncology, National Medical Center) ;
  • Kim, Chankyu (Proton Therapy Center, National Cancer Center) ;
  • Song, Mi Hee (Department of Radiation Oncology, National Medical Center) ;
  • Lee, Se Byeong (Proton Therapy Center, National Cancer Center)
  • 투고 : 2019.12.06
  • 심사 : 2019.12.18
  • 발행 : 2019.12.31
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초록

Purpose: The advantages of ocular proton therapy are that it spares the optic nerve and delivers the minimal dose to normal surrounding tissues. In this study, it developed a solid eye phantom that enabled us to perform quality assurance (QA) to verify the dose and beam range for passive single scattering proton therapy using a single phantom. For this purpose, a new solid eye phantom with a polymethyl-methacrylate (PMMA) wedge was developed using film dosimetry and an ionization chamber. Methods: The typical beam shape used for eye treatment is approximately 3 cm in diameter and the beam range is below 5 cm. Since proton therapy has a problem with beam range uncertainty due to differences in the stopping power of normal tissue, bone, air, etc, the beam range should be confirmed before treatment. A film can be placed on the slope of the phantom to evaluate the Spread-out Bragg Peak based on the water equivalent thickness value of PMMA on the film. In addition, an ionization chamber (Pin-point, PTW 31014) can be inserted into a hole in the phantom to measure the absolute dose. Results: The eye phantom was used for independent patient-specific QA. The differences in the output and beam range between the measurement and the planned treatment were less than 1.5% and 0.1 cm, respectively. Conclusions: An eye phantom was developed and the performance was successfully validated. The phantom can be employed to verify the output and beam range for ocular proton therapy.

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참고문헌

  1. Piersimoni P, Rimoldi A, Riccardi C, Pirola M, Molinelli S, Ciocca M. Optimization of a general-purpose, actively scanned proton beamline for ocular treatments: Geant4 simulations. J Appl Clin Med Phys. 2015;16:261-278. https://doi.org/10.1120/jacmp.v16i2.5227
  2. Barrett A, Dobbs J. Practical radiotherapy planning. 4th ed. London: Hodder Arnold; 2009.
  3. Gradoudas ES, Goitein M, Koehler A, Constable IJ, Wagner MS, Verhey L, et al. Proton irradiation of choroidal melanomas. Preliminary results. Arch Ophthalmol. 1978;96:1583-1591. https://doi.org/10.1001/archopht.1978.03910060217006
  4. Goitein M, Miller T. Planning proton therapy of the eye. Med Phys. 1983;10:275-283. https://doi.org/10.1118/1.595258
  5. Koch N, Newhauser W. Virtual commissioning of a treatment planning system for proton therapy of ocular cancers. Radiat Prot Dosimetry. 2005;115:159-163. https://doi.org/10.1093/rpd/nci224
  6. Newhauser W, Koch N, Hummel S, Ziegler M, Titt U. Monte Carlo simulations of a nozzle for the treatment of ocular tumours with high-energy proton beams. Phys Med Biol. 2005;50:5229-5249. https://doi.org/10.1088/0031-9155/50/22/002
  7. Vadrucci M, Esposito G, Ronsivalle C, Cherubini R, Marracino F, Montereali RM, et al. Calibration of GafChromic EBT3 for absorbed dose measurements in 5 MeV proton beam and (60)Co ${\gamma}$-rays. Med Phys. 2015;42:4678-4684. https://doi.org/10.1118/1.4926558
  8. Pai S, Das IJ, Dempsey JF, Lam KL, Losasso TJ, Olch AJ, et al. TG-69: radiographic film for megavoltage beam dosimetry. Med Phys. 2007;34:2228-2258. https://doi.org/10.1118/1.2736779
  9. Sipila P, Ojala J, Kaijaluoto S, Jokelainen I, Kosunen A. Gafchromic EBT3 film dosimetry in electron beams - energy dependence and improved film read-out. J Appl Clin Med Phys. 2016;17:360-373. https://doi.org/10.1120/jacmp.v17i1.5970
  10. Reinhardt S, Hillbrand M, Wilkens JJ, Assmann W. Comparison of Gafchromic EBT2 and EBT3 films for clinical photon and proton beams. Med Phys. 2012;39:5257-5262. https://doi.org/10.1118/1.4737890
  11. Sorriaux J, Kacperek A, Rossomme S, Lee JA, Bertrand D, Vynckier S, et al. Evaluation of $Gafchromic^{(R)}$ EBT3 films characteristics in therapy photon, electron and proton beams. Phys Med. 2013;29:599-606. https://doi.org/10.1016/j.ejmp.2012.10.001
  12. Birks JB. Theory and Practice of Scintillation Counting. New York: Pergamon; 1964.
  13. Torrisi L. Plastic scintillator investigations for relative dosimetry in proton-therapy. Nucl Instrum Methods Phys Res, Sec B. 2000;170:523-530. https://doi.org/10.1016/S0168-583X(00)00237-8
  14. Wang LL, Perles LA, Archambault L, Sahoo N, Mirkovic D, Beddar S. Determination of the quenching correction factors for plastic scintillation detectors in therapeutic highenergy proton beams. Phys Med Biol. 2012;57:7767-81. doi: 10.1088/0031-9155/57/23/7767.
  15. Chung K, Kim J, Kim DH, Ahn S, Han Y. The proton therapy nozzles at Samsung Medical Center: a Monte Carlo simulation study using TOPAS. J Korean Phys Soc. 2015;67:170-174. https://doi.org/10.3938/jkps.67.170
  16. Zhao L, Das IJ. Gafchromic EBT film dosimetry in proton beams. Phys Med Biol. 2010;55:N291-N301. https://doi.org/10.1088/0031-9155/55/10/N04
  17. Vatnitsky SM. Radiochromic film dosimetry for clinical proton beams. Appl Radiat Isot. 1997;48:643-651. https://doi.org/10.1016/S0969-8043(97)00342-4
  18. Kim DW, Chung WK, Shin J, Lim YK, Shin D, Lee SB, et al. Secondary neutron dose measurement for proton eye treatment using an eye snout with a borated neutron absorber. Radiat Oncol. 2013;8:182. https://doi.org/10.1186/1748-717X-8-182