CELLMED (셀메드)

Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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The regulatory effect of AST cream on atopic dermatitis-like skin disease.

  • Han, Na-Ra (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Hyung-Min (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Jeong, Hyun-Ja (Department of Food Science & Technology and Research Institute for Basic Science, Hoseo University)
  • Received : 2019.07.31
  • Accepted : 2019.08.16
  • Published : 2019.08.30
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Abstract

In this study, we investigated an inhibitory effect of AST cream on atopic dermatitis (AD) using a 2,4-dinitrochlorobenzene-induced AD murine model. Topical treatment with AST cream ameliorated the severity of AD-like lesional skin through decreases in infiltration of inflammatory cells and time of scratching behaviors. Also, AST cream reduced histamine and IgE levels in serum. The protein levels of IL-4 and IL-6 in AD-like lesional skin were suppressed by AST cream. These findings suggest that AST cream would be an alternative therapeutic agent for AD-like skin diseases.

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References

  1. Belloni Fortina A, Neri L. Antibiotic therapy in the management of atopic dermatitis. G Ital Dermatol Venereol. 2015;150(3):321-5.
  2. Choi JK, Kim SH. Rutin suppresses atopic dermatitis and allergic contact dermatitis. Exp Biol Med (Maywood). 2013;238(4):410-7. https://doi.org/10.1177/1535370213477975
  3. Han NR, Moon PD, Yoo MS, Ryu KJ, Kim HM, Jeong HJ. Regulatory effects of chrysophanol, a bioactive compound of AST2017-01 in a mouse model of 2,4-dinitrofluorobenzeneinduced atopic dermatitis. Int Immunopharmacol. 2018;62:220-6. https://doi.org/10.1016/j.intimp.2018.06.046
  4. Kim HY, Jee H, Yeom JH, Jeong HJ, Kim HM. The ameliorative effect of AST2017-01 in an ovalbumin-induced allergic rhinitis animal model. Inflamm Res. 2019;68:387-95. https://doi.org/10.1007/s00011-019-01226-y
  5. Klein P, Clark RAF. An Evidence-Based Review of the Efficacy of Antihistamines in Relieving Pruritus in atopic dermatitis. Arch Dermatol. 1999;135:1522-5.
  6. Klonowska J, Glen J, Nowicki RJ, Trzeciak M. New Cytokines in the Pathogenesis of Atopic Dermatitis-New Therapeutic Targets. Int J Mol Sci. 2018;19(10):3086. https://doi.org/10.3390/ijms19103086
  7. Konda D, Chandrashekar L, Rajappa M, Kattimani S, Thappa DM, Ananthanarayanan PH. Serotonin and interleukin-6: Association with pruritus severity, sleep quality and depression severity in Prurigo Nodularis. Asian J Psychiatr. 2015;17:24-8. https://doi.org/10.1016/j.ajp.2015.07.010
  8. Lee HH, Lee S, Lee K, Shin YS, Kang H, Cho H. Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis. Daru. 2015;23:35. https://doi.org/10.1186/s40199-015-0117-6
  9. Lowa A, Jevtic M, Gorreja F, Hedtrich S. Alternatives to animal testing in basic and preclinical research of atopic dermatitis. Exp Dermatol. 2018;27:476-83. https://doi.org/10.1111/exd.13498
  10. Matsui K, Tachioka K, Onodera K, Ikeda R. Topical Application of Josamycin Inhibits Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. J Pharm Pharm Sci. 2017;20:38-47. https://doi.org/10.18433/J3GW3D
  11. Navarini AA, French LE, Hofbauer GF. Interrupting IL-6-receptor signaling improves atopic dermatitis but associates with bacterial superinfection. J Allergy Clin Immunol. 2011;128(5):1128-30. https://doi.org/10.1016/j.jaci.2011.09.009
  12. Ng TB, Wang HX. Pharmacological actions of Cordyceps, a prized folk medicine. J Pharm Pharmacol. 2005;57:1509-19. https://doi.org/10.1211/jpp.57.12.0001
  13. Park DH, Jeong GT, Lee GM. Study of antimicrobial and antioxidant activities of Rumex crispus extract. Korean Chem Eng Res. 2006;44:81-6.
  14. Paton DM. Dupilumab: human monoclonal antibody against IL-4Ra for moderate to severe atopic dermatitis. Drugs Today. 2017;53:477-87. https://doi.org/10.1358/dot.2017.53.9.2693150
  15. Ryu KJ, Yoou MS, Seo Y, Yoon KW, Kim HM, Jeong HJ. Therapeutic effects of Artemisia scoparia Waldst. et Kitaib in a murine model of atopic dermatitis. Clin Exp Dermatol. 2018;43(7):798-805. https://doi.org/10.1111/ced.13565
  16. Venekamp RP, Prasad V, Hay AD. Are topical antibiotics an alternative to oral antibiotics for children with acute otitis media and ear discharge? BMJ. 2016;352:i308. https://doi.org/10.1136/bmj.i308
  17. Weber MB, Petry V, Weis L, Mazzotti NG, Cestari TF. Evaluating the relation between pruritus, serum IgE levels and severity of clinical manifestations in atopic dermatitis patients. An Bras Dermatol. 2005;80:245-8. https://doi.org/10.1590/S0365-05962005000300003
  18. Wong LS, Wu T, Lee CH. Inflammatory and Noninflammatory Itch: Implications in Pathophysiology-Directed Treatments. Int J Mol Sci. 2017;18(7):1485. https://doi.org/10.3390/ijms18071485