The Korean Journal of Physiology and Pharmacology

  • 제23권5호
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  • Pages.329-334
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  • 2019
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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Effect of gemigliptin on cardiac ischemia/reperfusion and spontaneous hypertensive rat models

  • Nam, Dae-Hwan (Predictive Model Research Center, Korea Institute of Toxicology) ;
  • Park, Jinsook (Corporate R&D, LG Chem, Ltd.) ;
  • Park, Sun-Hyun (Predictive Model Research Center, Korea Institute of Toxicology) ;
  • Kim, Ki-Suk (Predictive Model Research Center, Korea Institute of Toxicology) ;
  • Baek, Eun Bok (Corporate R&D, LG Chem, Ltd.)
  • 투고 : 2019.04.16
  • 심사 : 2019.07.24
  • 발행 : 2019.09.01
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초록

Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect of the DPP-IV inhibitor gemigliptin on ischemia/reperfusion (I/R)-induced myocardial injury and hypertension is unknown. In this study, we assessed the effects and mechanisms of gemigliptin in rat models of myocardial I/R injury and spontaneous hypertension. Gemigliptin (20 and 100 mg/kg/d) or vehicle was administered intragastrically to Sprague-Dawley rats for 4 weeks before induction of I/R injury. Gemigliptin exerted a preventive effect on I/R injury by improving hemodynamic function and reducing infarct size compared to the vehicle control group. Moreover, administration of gemigliptin (0.03% and 0.15%) powder in food for 4 weeks reversed hypertrophy and improved diastolic function in spontaneously hypertensive rats. We report here a novel effect of the gemigliptin on I/R injury and hypertension.

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참고문헌

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  1. Sitagliptin Modulates Oxidative, Nitrative and Halogenative Stress and Inflammatory Response in Rat Model of Hepatic Ischemia-Reperfusion vol.10, pp.8, 2019, https://doi.org/10.3390/antiox10081168