뇌졸중 이후 수면관련 행동장애를 보이는 환자에 대한 억간산가미 치험 2례

Two cases of Ukgansan-gami on Sleep-related Behavior Disorder after Stroke

  • 김수현 (경희대학교 대학원 임상한의학과 순환.신경내과학교실) ;
  • 이유진 (경희대학교 대학원 임상한의학과 순환.신경내과학교실) ;
  • 양정윤 (경희대학교 대학원 임상한의학과 순환.신경내과학교실) ;
  • 조기호 (경희대학교 대학원 임상한의학과 순환.신경내과학교실) ;
  • 문상관 (경희대학교 대학원 임상한의학과 순환.신경내과학교실) ;
  • 정우상 (경희대학교 대학원 임상한의학과 순환.신경내과학교실) ;
  • 권승원 (경희대학교 대학원 임상한의학과 순환.신경내과학교실) ;
  • 진철 (경희대학교 대학원 임상한의학과 순환.신경내과학교실)
  • Kim, Soohyun (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Lee, Yu Jin (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Yang, Jung-yun (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Cho, Ki-Ho (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Moon, Sang-Kwan (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Jung, Woo-Sang (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Kwon, Seungwon (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University) ;
  • Jin, Chul (Dept. of Clinical Korean medicine, Cardiology and Neurology, Graduate school, Kyung-Hee University)
  • 발행 : 2019.12.15

초록

■ Objectives This case study is to report the two cases of Ukgansan-gami on sleep-related behavior disorder after stroke. ■ Methods Two patients who had sleep-related behavior disorder after stroke were treated by Ukgansan-gami about a month. We evaluated these patients with the frequency and severity of symptoms. ■ Results During treatment period, decreases in both frequency and severity of symptoms were observed in two cases. ■ Conclusion Two patients who were suffered from sleep-related behavior disorder due to sequelae of stroke showed significant improvement of their symptom after taking Ukgansan-gami.

키워드

참고문헌

  1. 김대열. 뇌졸중 이후의 수면장애. 대한뇌신경재활학회지. 2015;8(2):73-80.
  2. 박웅, 유두만, 소준노. Planarian 모델을 이용한 억간산의 항발작 효과. 한국생물공학회. 2014;29(1):67-71.
  3. Matsui K, Sasai-Sakuma T, Ishigooka J et al. Effect of Yokukansan for the Treatment of Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective Analysis of Consecutive Patients. J Clin Sleep Med. 2019;15(8):1173-8. https://doi.org/10.5664/jcsm.7816
  4. 최은지, 서효원, 정선용 등. 성인 중증 지적장애에서의 문제행동에 대한 억간산가미(抑肝散加味) 치험 1례 보고. 동의신경정신과학회지. 2017;28(4):341-7. https://doi.org/10.7231/JON.2017.28.4.341
  5. Choe YM, Yoon IY, Kim KW, Lee SD, Ju GW, Park JH. Prevalence and Clinical Features of Probable REM Sleep Behavior Disorder-An Epidemiological Study in Osan City. Sleep Medicine and Psychophysiology. 2011;18(1):23-8. https://doi.org/10.14401/KASMED.2011.18.1.023
  6. 최윤희, 정진형, 김보경. REM 수면 행동장애의 치료에 대한 중의학 및 kampo의 연구 경향. 동의신경정신과학회지. 2013;24(4):343-51. https://doi.org/10.7231/jon.2013.24.4.343
  7. Shinno H. Successful treatment with Yi-Gan San for rapid eye movement sleep behavior disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(7):1749-51. https://doi.org/10.1016/j.pnpbp.2008.06.015
  8. Takeda A, Tamano H, Itoh H. et al. Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan. Neurochem Int. 2008;53(6-8):230-235. https://doi.org/10.1016/j.neuint.2008.07.009
  9. Takeda A, Itoh H, Tamano H. et al. Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats. Nutritional Neuroscience. 2008;11(1):41-6. https://doi.org/10.1179/147683008X301414
  10. Nishi A, Yamaguchi T, Sekiguchi K. et al. Geissoschizine methyl ether, an alkaloid in uncaria hook, is a potent serotonin 1A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan. Neuroscience. 2012;207:124-36. https://doi.org/10.1016/j.neuroscience.2012.01.037
  11. 강형원, 류영수. pCT105로 원격 유도된 PC12 세포에서 조구등으로부터 분리한 corynoxeine의 항치매 효과. 동의생리병리학회지. 2004;18(4):1111-9.
  12. Motohiro O. Effect of yokukansan psychophysiolgical insomnia evaluated using cyclic alternating pattern as an objective marker of sleep instability. Sleep and Biological Rhythms. 2012;10(2):157-60. https://doi.org/10.1111/j.1479-8425.2011.00527.x
  13. Shinotabe T. Efficacy of Yokukansan for REM sleep behavior disorder(RBD)-Comparison with clonazepam. Science of Kampo Medicine. 2013;37(1):22-5.
  14. Coe HV, Hong IS. Safety of low doses of quetiapine when used for insomnia. Ann Pharmacother. 2012;46(5):718-22. https://doi.org/10.1345/aph.1Q697