한국환경과학회지 (Journal of Environmental Science International)

  • 제28권7호
  • /
  • Pages.639-643
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  • 2019
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  • 1225-4517(pISSN)
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  • 2287-3503(eISSN)
한국환경과학회 (The Korean Environmental Sciences Society)
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흰점박이꽃무지(Protaetia brevitarsis) 추출물의 항혈전 효능

Antithrombotic Efficacy of Protaetia brevitarsis Extract

  • 최인학 (중부대학교 바이오융합학부) ;
  • 유리 (중부대학교 바이오융합학부) ;
  • 임연지 (중부대학교 바이오융합학부) ;
  • 최규성 (중부대학교 바이오융합학부) ;
  • 최성업 (동남보건대학교 식품제약과) ;
  • 황종익 (고려대학교 의과대학) ;
  • 손진성 ;
  • 정태호 (중부대학교 바이오융합학부)
  • Choi, In-Hag (Department of Companion Animal & Animal Resource, Joongbu Univeristy) ;
  • Yu, Ri (Department of Companion Animal & Animal Resource, Joongbu Univeristy) ;
  • Lim, Yeon-Ji (Department of Companion Animal & Animal Resource, Joongbu Univeristy) ;
  • Choi, Gyu-Sung (Department of Companion Animal & Animal Resource, Joongbu Univeristy) ;
  • Choi, Sung-Up (Food and Pharmaceutical Science, Dongnam Health University) ;
  • Hwang, Jong-Ik (College of Medicines, Korea University) ;
  • Son, Jin-Sung (HMO Health Dream Agricultural Association Corporation) ;
  • Chung, Tae-Ho (Department of Companion Animal & Animal Resource, Joongbu Univeristy)
  • 투고 : 2019.06.05
  • 심사 : 2019.07.05
  • 발행 : 2019.07.31
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초록

We aimed to evaluate antithrombotic efficacy of Protaetia brevitarsis extract during 21 days. Rats (SPF rat, weight 240~260 g) were divided into 16 groups (5 rats per group), they were: control group and Protaetia brevitarsis extract groups with dose of 0.1, 0.5, 1, 2.5, 5, 10, 25, 50, 75, 100, 200, 250, 500, 750, 1,000 mg/kg kg of body weight. Thromboplastin time (PT) and activated partial thromboplastin time (aPPT) as antithrombotic efficacy were tested in this animal experiment (at 7, 14 and 21 days). Overall, the admistration dose of Protaetia brevitarsis extract over 50 mg/kg at 7, 14 and 21 days for PT and over 25 mg/kg at 7, 14 and 21 days for aPPT tented to be longer than that of other groups. In addition, the optimal admistration doses of Protaetia brevitarsis extract to improves antithrombotic efficacy were 75, 100, 200 and 250 mg/kg at 7, 14 and 21 days for PT (p<0.05) and 50 and 100 mg/kg at 7 days, 75 mg/kg at 14 days, or 50, 100, 200 and 250 mg/kg at 21 days for aPPT (p<0.05). It can be concluded that Protaetia brevitarsis extract at optimal levels have antithrombotic efficacy.

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참고문헌

  1. Chung, H. K., Shin, M. J., Cha, Y. J., Lee, K. H., 2011, Effect of onion peel extracts on blood lipid profile and blood coagulation in high fat fed SD Rats, Korean J. Food. Nutr., 24, 442-450. https://doi.org/10.9799/ksfan.2011.24.3.442
  2. Jung, Y. J., Seo, Y. R., Kim, S. E., Kim, M. H., Hwang, J. H., Lee, J. Y., Park, J. K., 2018, "A Study on the biodiversity of Gyeongcheonseom island near the Sangju dam at Nakdong river, In Proceeding Korean Society Of Applied Entomology, 372-373.
  3. Kang, M. C., Kang, C. G., Lee, H. K., Kim, E. K., Kim, J. S., Kwon, O. S., Lee, H. K., Kang, H. J., Kim, C. H., Jang, H. S., 2012, Effects of fermented aloe vera mixed diet on larval growth of Protaetia brevitarsis seulensis (Kolbe)(coleopteran: Cetoniidae) and protective effects of its extract against $CCl_4$‐induced hepatotoxicity in Sprague-Dawley rats, Entomol res., 42, 111-121. https://doi.org/10.1111/j.1748-5967.2012.00444.x
  4. Lee, H. S., Ryu, H. J., Song, H. J., Lee, S. O., 2017a, Enzymatic preparation and antioxidant activities of protein hydrolysates from Protaetia brevitarsis larvae, J. Korean. Soc. Food. Sci. Nutr., 46, 1164-1170. https://doi.org/10.3746/jkfn.2017.46.10.1164
  5. Lee, J. E., Lee, A. J., Jo, D. E., Cho, J. H., Youn, K. J., Yun, E. Y., Hwang, J. S., Jun, M. R., Kang, B. H., 2015, Cytotoxic effects of Tenebrio molitor larval extracts against hepatocellular carcinoma, J. Korean. Soc. Food. Sci. Nutr., 44, 200-207. https://doi.org/10.3746/jkfn.2015.44.2.200
  6. Lee, J. I., Lee, W. H., Kim, M. A., Hwang, J. S., Na, M. K., Bae, J. S., 2017, Inhibition of platelet aggregation and thrombosis by indole alkaloids isolated from the edible insect Protaetia brevitarsis seulensis (Kolbe), J. Cell. Mol. Med., 21, 1217-1227. https://doi.org/10.1111/jcmm.13055
  7. Preston, R. J. S., O'Sullivan, J. M., O'Donnell, J. S., 2019, Advances in understanding the molecular mechanisms of venous thrombosis, Br. J. Haematol., 186, 13-23 https://doi.org/10.1111/bjh.15849
  8. Ryu, H. Y., Heo, J. C., Hwang, J. S., Kang, S. W., Yun, C. Y., Lee, S. H., Sohn, H. Y., 2008, Screening of Thrombin Inhibitor and its DPPH Radical Scavenging Activity from Wild Insects, J. Life. Sci., 18, 363-368. https://doi.org/10.5352/JLS.2008.18.3.363