Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Aldose reductase inhibition of the methanolic extracts of selected noxious and exotic plants

  • Lee, Ju Sung (Department of Plant Science and Technology, Chung-Ang University) ;
  • Woo, Dong Geon (Sejong Academy of Science and Arts) ;
  • Cho, Ga Eul (Sejong Academy of Science and Arts) ;
  • Lee, Sanghyun (Department of Plant Science and Technology, Chung-Ang University)
  • Received : 2019.04.09
  • Accepted : 2019.06.04
  • Published : 2019.06.30
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Abstract

The inhibition of aldose reductase (AR) by the extracts from sixteen noxious and exotic plants was examined. Among them, Aster pilosus showed the highest inhibition of AR ($IC_{50}$ value $0.11{\mu}g/mL$). This study showed that A. pilosus with promising AR-inhibitory activities can be utilized for the development of natural therapies for treating and managing diabetic complications.

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References

  1. Alba C, Skalova H, McGregor KF, D'Antonio C, Pysek P (2015) Native and exotic plant species and prescribed fire as revealed by meta-analysis. J Veget Sci 26: 102-113 https://doi.org/10.1111/jvs.12212
  2. Cheung AK, Fung MK, Lo AC, Lam TT, So KF, Chung SS, Chung SK (2005) Aldose reductase deficiency prevents diabetes-induced bloodretinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice. Diabetes 54: 3119 -3125 https://doi.org/10.2337/diabetes.54.11.3119
  3. Mok S-Y, Lee S (2013) Identification of flavonoids and flavonoid rhamnosides from Rhododendron mucronulatum for. albiflorum and their inhibitory activities against aldose reductase. Food Chem 136: 969-974 https://doi.org/10.1016/j.foodchem.2012.08.091
  4. Hayman S, Kinoshita JJ (1965) Isolation and properties of lens aldose reductase. Biol Chem 240: 877-882 https://doi.org/10.1016/S0021-9258(17)45256-2
  5. Engerman RL, Kern TS, Larson ME (1994) Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs. Diabetologia 37: 141-144 https://doi.org/10.1007/s001250050084
  6. Brownlee M (2004) Biology and molecular cell biology of diabetic complications. Diabetes 54: 1615-1625 https://doi.org/10.2337/diabetes.54.6.1615
  7. Song W, Wang HJ, Bucheli P, Zhang PF, Wei DZ, Lu YH (2009) Phytochemical profiles of different mulberry (Morus sp.) species from China. J Agric Food Chem 57: 9133-9140 https://doi.org/10.1021/jf9022228
  8. Deschner E, Ruperto J, Wong G, Newmark H (1991) Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 12: 1193-1196 https://doi.org/10.1093/carcin/12.7.1193
  9. Vessal M, Hemmati M, Vasei M (2003) Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp Biochem Physiol C 135: 357-364 https://doi.org/10.1016/S1095-6433(03)00090-4
  10. Boots A, Haenen GRMM, Bast A (2008) Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 585: 325-337 https://doi.org/10.1016/j.ejphar.2008.03.008
  11. Ji Hyun Kim, Sanghyun Lee, Eun Ju Cho, Hyun Young Kim (2019) Neuroprotective effects of kaempferol, quercetin, and its glycosides by regulation of apoptosis. J Korea Acad-Indus Cooper Soc 20: 286-293
  12. Varma SD, Mikuni I, Kinoshita JH (1975) Flavonoids as inhibitors of lens aldose reductase. Science 188: 1215-1216 https://doi.org/10.1126/science.1145193
  13. Yawadio R, Tanimori S, Morita N (2007) Identification of phenolic compounds isolated from pigmented rices and their aldose reductase inhibitory activities. Food Chem 101: 1616-1625 https://doi.org/10.1016/j.foodchem.2006.04.016
  14. Fossen T, Larsen A, Kiremire B, Andersen O (1999) Flavonoids from blue flowers of Nymphaea caerulea. Phytochemistry 51: 1133-1137 https://doi.org/10.1016/S0031-9422(99)00049-7
  15. Swaroop A, Gupta P, Sinha K (2005) Simultaneous determination of quercetin, rutin, and coumaric acid in flowers of Rhododendron arboreum by HPTLC. Chromatographia 62: 649-652 https://doi.org/10.1365/s10337-005-0669-6
  16. Lee J, Rodriguez JP, Quilantang NG, Lee M-H, Cho EJ, Jacinto SD, Lee S (2017) Determination of flavonoids from Perilla frutescens var. japonica seeds and their inhibitory effect on aldose reductase. Appl Biol Chem 60: 155-162 https://doi.org/10.1007/s13765-017-0260-5
  17. Lee J, Rodriguez JP, Lee KH, Park JY, Kang KS, Hahm D-H, Huh CK, Lee SC, Lee S (2017) Determination of flavonoids from Cirsium japonicum var. maackii and their inhibitory activities against aldose reductase. Appl Biol Chem 60: 487-496 https://doi.org/10.1007/s13765-017-0302-z
  18. Rodriguez JP, Lee YK, Woo DG, Shim JS, Geraldino PJL, Jacinto SD, Lee S (2018) Flavonoids from Cirsium japonicum var. maackii pappus as inhibitors of aldose reductase and their simultaneous determination. Chem Pap 72: 81-88 https://doi.org/10.1007/s11696-017-0259-8
  19. Lee J, Lee D-G, Rodriguez JP, Park JY, Cho EJ, Jacinto SD, Lee S (2018) Determination of flavonoids in Acer okamotoanum and their aldose reductase inhibitory activities. Hort Environ Biotechnol 59: 131-137 https://doi.org/10.1007/s13580-018-0014-2
  20. Quilantang NG, Ryu SH, Park SH, Byun JS, Chun JS, Lee JS, Rodriguez JP, Yun YS, Jacinto SD, Lee S (2018) Inhibitory activity of methanol extracts from different colored flowers on aldose reductase and HPLC-UV analysis of quercetin. Hort Environ Biotechnol 59: 899-907 https://doi.org/10.1007/s13580-018-0072-5
  21. Lai J-P, Lim YH, Su J, Shen H-M, Ong CN (2007) Identification and characterization of major flavonoids and caffeolyquinic acids in three Compositae plants by LC/DAD-APCI/MS. J Chromatogr B 848: 215-225 https://doi.org/10.1016/j.jchromb.2006.10.028
  22. Tamura Y, Hattori M, Konno K, Honda H, Ono H, Yoshida M (2003) Triterpenoid and caffeic acid derivatives in the leaves of ragweed, Ambrosia artemisiifolia L. (Asterales: Asteraceae), as feeding stimulants of Ophraella communa LeSage (Coleoptera: Chrysomelidae). Chemoecol 14: 113-118 https://doi.org/10.1007/s00049-004-0269-1
  23. Sharma P, Mohan L, Srivastava CN (2005) Larvicidal potential of Nerium indicum and Thuja orientalis extracts against malaria and Japanese encephalitis vector. J Environ Biol 26: 657-660