Fig. 1. Viremia and average daily weight gain (ADWG) after challenge with PRRSV.
Table 1. The information of primers and probes used for genotyping
Table 2. The genotyping results on sperm samples from DH farm
Table 3. Genotyping results of piglets produced with GBP1E2-AG sperms
Table 4. Genotyping results of piglets produced with GBP1E2-GG sperms
참고문헌
- Boddicker N, Waide EH, Rowland RR, Lunney JK, Garrick DJ, Reecy JM, Dekkers JC. 2012. Evidence for a major QTL associated with host response to porcine reproductive and respiratory syndrome virus challenge. J Anim Sci 90, 1733-1746. https://doi.org/10.2527/jas.2011-4464
- Boddicker NJ, Bjorkquist A, Rowland RR, Lunney JK, Reecy JM, Dekkers JC. 2014. Genome-wide association and genomic prediction for host response to porcine reproductive and respiratory syndrome virus infection. Genet Sel Evol 46, 18. https://doi.org/10.1186/1297-9686-46-18
- Dekkers J, Rowland RRR, Lunney JK, Plastow G. 2017. Host genetics of response to porcine reproductive and respiratory syndrome in nursery pigs. Vet Microbiol 209, 107-113. https://doi.org/10.1016/j.vetmic.2017.03.026
- Gol S, Estany J, Fraile LJ, Pena RN. 2015. Expression profiling of the GBP1 gene as a candidate gene for porcine reproductive and respiratory syndrome resistance. Anim Genet 46, 599-606. https://doi.org/10.1111/age.12347
- Hess AS, Islam Z, Hess MK, Rowland RR, Lunney JK, Doeschl-Wilson A, Plastow GS, Dekkers JC. 2016. Comparison of host genetic factors influencing pig response to infection with two North American isolates of porcine reproductive and respiratory syndrome virus. Genet Sel Evol 48, 43. https://doi.org/10.1186/s12711-016-0222-0
- Kim JY, Lee SY, Sur JH, Lyoo YS. 2006. Serological and genetic characterization of the European strain of the PRRSV isolated in Korea. Korean Journal of Veterinary Research 46, 363-370.
- Koltes JE, Fritz-Waters E, Eisley CJ, Choi I, Bao H, Kommadath A, Serao NV, Boddicker NJ, Abrams SM, Schroyen M, Loyd H, Tuggle CK, Plastow GS, Guan L, Stothard P, Lunney JK, Liu P, Carpenter S, Rowland RR, Dekkers JC, Reecy JM. 2015. Identification of a putative quantitative trait nucleotide in guanylate binding protein 5 for host response to PRRS virus infection. BMC Genomics 16, 412. https://doi.org/10.1186/s12864-015-1635-9
- Kommadath A, Bao H, Choi I, Reecy JM, Koltes JE, Fritz-Waters E, Eisley CJ, Grant JR, Rowland RR, Tuggle CK, Dekkers JC, Lunney JK, Guan LL, Stothard P, Plastow GS. 2017. Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection. Sci Rep 7, 46203. https://doi.org/10.1038/srep46203
- Ma G, Huang J, Sun N, Liu X, Zhu M, Wu Z, Zhao S. 2008. Molecular characterization of the porcine GBP1 and GBP2 genes. Mol Immunol 45, 2797-2807. https://doi.org/10.1016/j.molimm.2008.02.007
- Meng XJ, Paul PS, Halbur PG, Lum MA. 1995. Phylogenetic analyses of the putative M (ORF 6) and N (ORF 7) genes of porcine reproductive and respiratory syndrome virus (PRRSV): implication for the existence of two genotypes of PRRSV in the U.S.A. and Europe. Arch Virol 140, 745-755. https://doi.org/10.1007/BF01309962
- Nam E, Park CK, Kim SH, Joo YS, Yeo SG, Lee C. 2009. Complete genomic characterization of a European type 1 porcine reproductive and respiratory syndrome virus isolate in Korea. Arch Virol 154, 629-638. https://doi.org/10.1007/s00705-009-0347-3
- Nelsen CJ, Murtaugh MP, Faaberg KS. 1999. Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents. J Virol 73, 270-280. https://doi.org/10.1128/JVI.73.1.270-280.1999
- Neumann EJ, Kliebenstein JB, Johnson CD, Mabry JW, Bush EJ, Seitzinger AH, Green AL, Zimmerman JJ. 2005. Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J Am Vet Med Assoc 227, 385-392. https://doi.org/10.2460/javma.2005.227.385
- Niu P, Shabir N, Khatun A, Seo BJ, Gu S, Lee SM, Lim SK, Kim KS, Kim WI. 2016. Effect of polymorphisms in the GBP1, Mx1 and CD163 genes on host responses to PRRSV infection in pigs. Vet Microbiol 182, 187-195. https://doi.org/10.1016/j.vetmic.2015.11.010
- Park CK, Yoon HC, Lee CH, Jung BY, Lee KK, Kim HS. 2008. Infection patterns of porcine reproductive and respiratory syndrome virus by serological analysis on a farm level. Korean Journal of Veterinary Research 48, 67-73.
- Rowland RRR, Lunney J, Dekkers J. 2012. Control of porcine reproductive and respiratory syndrome (PRRS) through genetic improvements in disease resistance and tolerance. Frontiers in Genetics e3, 260.
- Seo BJ, Kim HI, Kim WI. 2014. Comparative evaluation of two commercial ELISA kits for detection of PRRS antibodies using sera collected from pigs in various stages of PRRSV infection. Korean Journal of Veterinary Research 37, 151-156.
- Serao NV, Matika O, Kemp RA, Harding JC, Bishop SC, Plastow GS, Dekkers JC. 2014. Genetic analysis of reproductive traits and antibody response in a PRRS outbreak herd. J Anim Sci 92, 2905-2921. https://doi.org/10.2527/jas.2014-7821
- Shenoy AR, Wellington DA, Kumar P, Kassa H, Booth CJ, Cresswell P, MacMicking JD. 2012. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science 336, 481-485. https://doi.org/10.1126/science.1217141
- Vestal DJ, Jeyaratnam JA. 2011. The Guanylate-Binding Proteins: Emerging Insights into the Biochemical Properties and Functions of This Family of Large Interferon-Induced Guanosine Triphosphatase. J Interf Cytok Res 31, 89-97. https://doi.org/10.1089/jir.2010.0102
- Waide EH, Tuggle CK, Serao NV, Schroyen M, Hess A, Rowland RR, Lunney JK, Plastow G, Dekkers JC. 2017. Genomewide association of piglet responses to infection with one of two porcine reproductive and respiratory syndrome virus isolates. J Anim Sci 95, 16-38.
- Yoon SH., Song JY, Lee CH, Choi EJ, Cho IS, Kim B. 2008. Genetic characterization of the Korean porcine reproductive and respiratory syndrome viruses based on the nucleocapsid protein gene (ORF7) sequences. Arch Virol 153, 627-635. https://doi.org/10.1007/s00705-007-0027-0
피인용 문헌
- 3D8 scFv 형질전환 돼지 개발 및 PRRS 저항성 평가 vol.43, pp.4, 2019, https://doi.org/10.7853/kjvs.2020.43.4.227