Neonatal Medicine

  • 제26권1호
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  • Pages.48-54
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  • 2019
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  • 2287-9412(pISSN)
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  • 2287-9803(eISSN)
대한신생아학회 (The Korean Society of Neonatology)
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Comparison of Clinical Factors and Neurodevelopmental Outcomes between Early- and Late-Onset Periventricular Leukomalacia in Very Low Birth Weight Infants

  • Bae, Mihye (Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine) ;
  • Lee, Narae (Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine) ;
  • Han, Young Mi (Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine) ;
  • Park, Kyung Hee (Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine) ;
  • Byun, Shin Yun (Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine)
  • 투고 : 2018.09.27
  • 심사 : 2019.02.12
  • 발행 : 2019.02.28
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초록

Purpose: To analyze and compare the clinical factors and neurodevelopmental outcomes compare early- and late-onset periventricular leukomalacia (PVL) in very low birth weight infants (VLBWI). Methods: We performed a retrospective study involving 199 newborn infants weighing <1,500 g admitted to the neonatal intensive care unit between March 2009 and December 2015. VLBWI with PVL were categorized into early- and late-onset PVL groups based on the time of diagnosis based on 28 days of age. We analyzed the clinical factors and neurodevelopmental outcomes between the groups. Results: The incidence rate of PVL was 10.1% (16/158). The Apgar score at 1 minute and the mean duration of tocolytic therapy were associated with the development of PVL. The incidence rate of premature rupture of membranes (PROM) was significantly higher in the early-onset PVL group (P=0.041). No significant differences were observed in neurodevelopmental outcomes between the early- and late-onset PVL groups. Conclusion: Results suggest that a higher incidence of PROM was associated with clinical characteristics in the early-onset PVL group. No significant intergroup differences were observed in neurodevelopmental outcomes; however, the Bayley Scales of Infant Development-III scores were lower in the early-onset PVL group.

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과제정보

이 연구는 2018년도 부산대학교병원 임상연구비 지원으로 이루어졌습니다.

참고문헌

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