동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제33권1호
  • /
  • Pages.63-67
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  • 2019
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
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Cosmetic Potency of Puerariae Radix in Dermal Fibroblasts

  • Lee, Jae Yun (Department of Herbal Resources, Graduate School of Oriental Medicine, Wonkwang University) ;
  • Park, Seo A (Department of Beauty Design Graduate School, Wonkwang University) ;
  • Woo, Won Hong (Department of Anatomy, School of Oriental Medicine, Wonkwang University) ;
  • Mun, Yeun Ja (Department of Herbal Resources, Graduate School of Oriental Medicine, Wonkwang University)
  • 투고 : 2019.01.07
  • 심사 : 2019.02.20
  • 발행 : 2019.02.25
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초록

Interaction between epidermis and dermis plays an important role in wound healing and hair follicle formation. This study focused on investigating the potency of ethanol extract of Puerariae Radix (EPR) as cosmetic ingredient using human dermal fibroblasts (hDFn). Our results revealed that EPR suppressed collagenase activity dose-dependently. EPR inhibited activity of $5{\alpha}$-reductase I and II at the final concentration of $25{\mu}g/ml$ in hDFn cells. Also, EPR promoted the proliferation and the ERK activation of cells. ERK phosphorylation by EPR was blocked by specific inhibitor of ERK, PD98059. EPR-induced cell proliferation was blocked by PD98059. This means that EPR could promote the proliferation of hDFn cells via the activation ERK. Collectively, these results suggest that EPR may be used as a new cosmetic ingredient.

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