DOI QR코드

DOI QR Code

Analysis of major ginsenosides in various ginseng samples

  • Lee, Dong Gu (Department of Plant Science and Technology, Chung-Ang University) ;
  • Lee, Ju Sung (Department of Plant Science and Technology, Chung-Ang University) ;
  • Kim, Kyung-Tack (Korea Food Research Institute) ;
  • Kim, Hyun Young (Department of Food Science, Gyeongnam National University of Science and Technology) ;
  • Lee, Sanghyun (Department of Plant Science and Technology, Chung-Ang University)
  • Received : 2018.11.15
  • Accepted : 2019.02.07
  • Published : 2019.03.31

Abstract

The contents of major ginsenosides (ginsenosides Rb1, ginsenoside Rc, ginsenoside Rd, ginsenoside Re, ginsenoside Rf, and ginsenoside Rg1) in ginseng cultivated in different areas in Korea, ginseng that underwent different cultivation processes and ages, and ginseng cultivated in different countries were determined using high-performance liquid chromatography equipped with UV/VIS detector. Ginsenoside Rc was the most abundant ginsenoside in all different ginseng samples. The highest total concentration of major ginsenosides was found in the ginseng cultivated in Jinan (0.931 mg/g) and 4-year grown red ginseng (1.785 mg/g). Major ginsenosides were the most abundant in Korean ginseng (1.264 mg/g), compared to those in Chinese and American ginseng. The results of this study showed the different contents of major ginsenosides in the ginseng samples tested and emphasized which sample could contain high yield of ginsenosides.

Keywords

References

  1. Furukawa T, Bai C-X, Kaihara A, Ozaki E, Kawano T, Nakaya Y, Awais M, Sato M, Umezawa Y, Kurokawa J (2006) Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones. Mol Pharmacol 70: 1916-1924 https://doi.org/10.1124/mol.106.028134
  2. Lee SA, Bae B-S, Park H-W, Ahn N-G, Cho B-G, Cho Y-L, Kwak Y-S (2015) Characterization of Korean red ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition. J Ginseng Res 39: 384-391 https://doi.org/10.1016/j.jgr.2015.04.009
  3. Chung I-M, Lim J-J, Ahn M-S, Jeong H-N, An T-J (2016) Comparative phenolic compound profiles and antioxidative activity of the fruit, leaves, and roots of Korean ginseng (Panax ginseng Meyer) according to cultivation years. J Ginseng Res 40: 68-75 https://doi.org/10.1016/j.jgr.2015.05.006
  4. Kim JH, Yi YS, Kim MY, Cho JY (2017) Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. J Ginseng Res 41: 435-443 https://doi.org/10.1016/j.jgr.2016.08.004
  5. Zhang K, Wang X, Ding L, Li J, Qu CL, Chen LG, Jin HY, Zhang HQ (2008) Determination of seven major ginsenosides in different Panax quinquefolius L. (American ginseng) with different ages. Chem Res Chinese Universities 24: 707-711 https://doi.org/10.1016/S1005-9040(09)60011-8
  6. Lee CH, Kim JH (2014) A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases. J Ginseng Res 38: 161-166 https://doi.org/10.1016/j.jgr.2014.03.001
  7. Yang W, Qiao X, Li K, Fan J, Bo T, Guo D-A, Ye M (2016) Identification and differentiation of Panax ginseng, Panax quinqefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers. Acta Pharm Sin B 6: 568-575 https://doi.org/10.1016/j.apsb.2016.05.005
  8. Shi X-J, Yang W-Z, Qiu S, Yao C-I, Shen Y, Pan H-Q, Bi Q-R, Yang M, Wu W-Y, Guo D-A (2017) An in-source multiple collision-neutral loss filtering based nontargeted metabolomics approach for the comprehensive analysis of malonyl-ginsenosides from Panax ginseng, P. quinquefolius, and P. notoginseng. Anal Chim Acta 952: 59-70 https://doi.org/10.1016/j.aca.2016.11.032
  9. Ru W, Wang D, Xu Y, He X, Sun Y-E, Qian L, Zhou X, Qin Y (2015) Chemical constituents and bioactivities of Panax ginseng (C.A. Mey.). Drug Discov Ther 9: 23-32 https://doi.org/10.5582/ddt.2015.01004
  10. Park SE, Na CS, Yoo SA, Seo SH, Son HS (2017) Biotransformation of major ginsenosides in ginsenoside model culture by lactic acid bacteria. J Ginseng Res 41: 36-42 https://doi.org/10.1016/j.jgr.2015.12.008
  11. Hanagata N (2012) Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system. Int J Nanomed 7: 2181-2195 https://doi.org/10.2147/ijn.s30197
  12. Jang H-E, Jung H, Mok H (2017) Cleavable conjugation of CpG oligodeoxynucleotides onto microparticles for facile release and cytokine induction in macrophages. Appl Biol Chem 60: 321-326 https://doi.org/10.1007/s13765-017-0284-x
  13. Castro-Aceituno V, Ahn S, Simu SY, Singh P, Mathiyalagan R, Lee HA, Yang DC (2016) Anticancer activity of silver nanoparticles from Panax ginseng fresh leaves in human cancer cells. Biomed Pharmacother 84: 158-165 https://doi.org/10.1016/j.biopha.2016.09.016
  14. Lee DG, Lee J, Yang S, Kim K-T, Lee S (2015) Identification of dammarane-type triterpenoid saponins from the roots of Panax ginseng. Nat Prod Sci 21: 111-121
  15. Kim DH, Park CH, Park D, Choi YJ, Park MH, Chung KW, Kim SR, Lee JS, Chung HY (2014) Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress. Arch Pharm Res 37: 813-820 https://doi.org/10.1007/s12272-013-0223-2
  16. Lee DG, Lee J, Kim K-T, Lee S-W, Kim Y-O, Cho I-H, Kim H-J, Park C-G, Lee S (2018) High-performance liquid chromatography analysis of phytosterols in Panax ginseng root grown under different conditions. J Ginseng Res 42: 16-20 https://doi.org/10.1016/j.jgr.2016.10.004
  17. Ahn SI, Kim SK, Yang BW, Lee ES, Kang CS, Hahm YT (2016) Analysis of ginsenosides and non-saponin components of red ginseng from landraces and new varieties. Korean J Hortic Sci Technol 34: 790-798
  18. Lee CR, Whang WK, Shin CG, Lee HS, Han ST, Im BO, Ko SK (2004) Comparison of ginsenoside composition and contents in fresh ginseng roots cultivated in Korea, Japan, and China at various ages. Korean J Food Sci Technol 36: 847-850
  19. Lee SA, Liuting, Jo HK, Im BO, Cho SH, Whang WK, Ko SK (2010) The comparison of ginsenoside composition contents in notoginseng radix (Sanchi) on various parts and ages. Kor J Pharmacogn 41: 319-322
  20. Kim SN, Ha YW, Shin H, Son SH, Wu SJ, Kim YS (2007) Simultaneous quantification of 14 ginsenosides in Panax ginseng C.A. Meyer (Korean red ginseng) by HPLC-ELSD and its application to quality control. J Pharm Biomed Anal 45: 164-170 https://doi.org/10.1016/j.jpba.2007.05.001
  21. Lee SM (2014) Thermal conversion pathways of ginsenosides in red ginseng processing. Nat Prod Sci 20: 119-125

Cited by

  1. Comprehensive Quality Evaluation of American Ginseng for Different Parts and Abnormal Trait Based on the Major Ginsenoside Contents and Morphological Characteristics vol.2021, 2019, https://doi.org/10.1155/2021/8831080
  2. Anticancer Activities of Ginsenosides, the Main Active Components of Ginseng vol.2021, 2021, https://doi.org/10.1155/2021/8858006