Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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Study on Correlation between Cognitive Impairment and Geriatric Depression or Geriatric Stress

인지기능과 노인성 우울, 노인성 스트레스의 연관성에 대한 연구

  • Kim, Dae Jin (Department of Neurology, Pusan National University Yangsan Hospital) ;
  • Cho, Soo-Young (Department of Neurology, Seoul National University Hospital) ;
  • Choi, Jeong Su (Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University) ;
  • Lee, Min Woo (Institute of Health Science, College of Health Science, Korea University) ;
  • Cho, Eun-Kyung (Department of Laboratory Medicine, Graduate School of Medicine, Kangwon National University) ;
  • Kang, Se-hee (Department of Neurology, Seoul National University Hospital) ;
  • Kim, Suhng Wook (Department of Health and Safety Convergence Science, Graduate School, Korea University)
  • 김대진 (부산대학교 양산병원 신경과) ;
  • 조수영 (서울대학교병원 신경과) ;
  • 최정수 (고려대학교 대학원 의생명융합과학과) ;
  • 이민우 (고려대학교 보건과학대학 보건과학연구소) ;
  • 조은경 (강원대학교 의학과대학원 진단검사의학전공) ;
  • 강세희 (서울대학교병원 신경과) ;
  • 김성욱 (고려대학교 대학원 보건안전융합과학과)
  • Received : 2019.01.04
  • Accepted : 2019.02.08
  • Published : 2019.03.31
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Abstract

This study examined the effects of geriatric depression and geriatric stress on cognitive impairment. In particular, the dementia groups were divided into Alzheimer's disease and vascular dementia. A normal group was used as the control group. For each group, the geriatric depression using the geriatric depression scale (GDS) and geriatric stress using the geriatric stress scale (GSS) was compared with the regression and correlation results of cognitive impairment. Statistical tests, such as descriptive statistics, Kruskall-Wallis, correlation analysis, and multiple regression analysis, were performed. For the Alzheimer's group, the GDS and GSS correlated with the cognitive impairment, but only the GDS showed a cause-and-effect relationship with cognitive impairment. In particular, the male group with Alzheimer's disease showed clear confirmation. In addition, geriatric stress was found to be associated with geriatric depression. In conclusion, geriatric depression affects the cognitive impairment directly and geriatric stress affects the cognitive ability indirectly through geriatric depression. In this study, the Alzheimer's disease, vascular dementia, and control groups had a small sample size. Therefore, the external validity in future studies can be increased using a larger sample size for each group.

본 연구의 목적은 노인성 우울, 노인성 스트레스와 인지기능과의 연관성을 확인하는 것이다. 구체적으로 치매를 유발 원인에 따라 알츠하이머성 치매와 혈관성 치매의 두 그룹으로 분류하고 각 그룹의 인지장애 및 노인성 우울, 노인성 스트레스의 정도와 특성의 차이를 확인하고 상호간의 연관성을 비교하고자 한다. 인지기능의 변수는 한국형 간이정신상태검사, 치매임상평가척도, 이마엽 기능검사, 한국형 도구적 일상생활능력 평가를 사용하였고, 노인성 우울변수는 노인우울척도(GDS), 노인성 스트레스변수는 노인스트레스척도(GSS)를 사용하였다. 통계적 방법은 알츠하이머성 치매환자 80명, 혈관성 치매환자 80명, 통제를 위한 정상군 80명을 설정하여 기술 통계량, Kruskall-Wallis, 상관분석, 다중회귀분석으로 통계적으로 유의한 차이 및 연관성을 확인하였다. 알츠하이머성 치매군에서는 GDS, GSS와 대체적으로 인지기능 변수들과의 상관관계는 확인하였다. 특히 GDS는 남성에서만 인지기능 변수들과 상관관계가 있고, 인지기능 변수들과의 인과관계도 확인되었다. 또한 GSS와 GDS와의 인과관계를 확인하여 GSS가 GDS의 원인이 된다는 유의성을 확인하였다. 결론적으로 GDS는 알츠하이머성 치매군에서 인지기능 변수와의 상관관계와 직접적인 인과관계를 확인하였고, GSS는 직접적인 상관관계보다 GDS를 유발하여 인지기능 장애와의 간접적인 인과관계를 확인할 수 있었다.

Keywords

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