대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지
DOI QR코드

DOI QR Code

한약복용이 한방병원 입원환자의 간 기능에 미치는 영향에 대한 후향적 관찰

Effect of Herbal Medicine on Liver Function in Korean Medical Hospital Inpatients: A Retrospective Chart Review

  • 서형범 (부산대학교 한의학전문대학원 내과학교실) ;
  • 서희정 (부산대학교 한의학전문대학원 내과학교실) ;
  • 심소현 (부산대학교 한의학전문대학원 내과학교실) ;
  • 이찬 (부산대학교 한의학전문대학원 내과학교실) ;
  • 조임학 (부산대학교 한의학전문대학원 내과학교실) ;
  • 한창우 (부산대학교 한의학전문대학원 내과학교실) ;
  • 김소연 (부산대학교 한의학전문대학원 내과학교실) ;
  • 최준용 (부산대학교 한의학전문대학원 내과학교실) ;
  • 박성하 (부산대학교 한의학전문대학원 내과학교실) ;
  • 윤영주 (부산대학교 한의학전문대학원 내과학교실) ;
  • 홍진우 (부산대학교 한의학전문대학원 내과학교실) ;
  • 권정남 (부산대학교 한의학전문대학원 내과학교실) ;
  • 이인 (부산대학교 한의학전문대학원 내과학교실)
  • Seo, Hyung-bum (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Seo, Hee-jeong (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Shim, So-hyun (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Lee, Chan (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Cho, Im- hak (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Han, Chang-woo (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Kim, So-yeon (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Choi, Jun-yong (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Park, Seong-ha (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Yun, Young-ju (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Hong, Jin-woo (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Kwon, Jung-nam (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University) ;
  • Lee, In (Dept. of Korean Internal Medicine, School of Korean Medicine, Pusan National University)
  • 투고 : 2019.11.29
  • 심사 : 2019.12.27
  • 발행 : 2019.12.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: The purpose of this study was to investigate liver function test results in admitted patients before and after herbal treatment. Methods: 54 subjects admitted to hospital had liver function tests (aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin) before and after herbal treatment from 1 March 2017 to 30 June 2019. Results: Aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were not significantly changed (p>0.05). On admission, 11 patients had abnormal liver function, while seven patients had abnormal results in alkaline phosphatase upon discharge. Three of the seven were normal when they were hospitalized. Conclusions: This study suggests that herbal treatment may have no effect on liver injury.

키워드

참고문헌

  1. Chae HB. Clinical features and diagnosis of drug-induced liver injury. Korean J Hepatol 2004;10(Suppl1):7-18.
  2. Lim JH, Kim YS, Lee YN, Kim SG, Jeong SW, Jang JY, et al. Clinical Characteristics and Pathological Findings in Patients with Toxic Hepatitis. Korean J Med 2011;81(1):53-63.
  3. Yun YJ, Shin BC, Lee MS, Cho SI, Shin WJ, Park HJ, et al. Korean Herbal Medicine on Liver Function : A Systematic Review in Korean Literature. Korean J Orient Int Med 2009;30(1):153-72.
  4. Suk KT, Kim DJ, Kim CH, Park SH, Yoon JH, Kim YS, et al. A prospective nationwide study of drug-induced liver injury in Korea. Am J Gastroenterol 2012;107(9):1380-7. https://doi.org/10.1038/ajg.2012.138
  5. Cho JH, Oh DS, Hong SH, Ko H, Lee NH, Park SE, et al. A nationwide study of the incidence rate of herb-induced liver injury in Korea. Arch Toxicol 2017;91(12):4009-15. https://doi.org/10.1007/s00204-017-2007-9
  6. Danan G, Teschke R. RUCAM in Drug and Herb Induced Liver Injury: The Update. Int J Mol Sci 2015;24;17(1);pii: E14. doi: 10.3390/ijms17010014.
  7. Park YC, Park HM, Lee SD. Inducible Mechanisms for Hepatotoxicity caused by Traditional Korean Medicines in a View of Toxicology. The Journal of Korean Medicine 2011;32(4):48-67.
  8. Chun WJ, Yoon BG, Kim NI, Lee G, Yang CH, Lee CW, et al. A clinical study of patients with acute liver injury caused by herbal medication in Gyeongju area. Korean Journal of Medicine 2002;63(2):141-50.
  9. 김동준. 식이유래 독성간염의 진단 및 보고체계구축을 위한 다기관 예비연구 최종보고서. 서울: 국립독성연구원; 2003.
  10. Jeong TY, Park BK, Cho JH, Kim YI, Ahn YC, Son CG. A prospective study on the safety of herbal medicines, used aloneor with conventional medicines. Journal of Ethnopharmacology 2012;143(3):884-8. https://doi.org/10.1016/j.jep.2012.08.016
  11. Lee JH, Shin JS, Kim MR, Byun JH, Lee SY, Shin YS, et al. Liver enzyme abnormalities in taking traditional herbal medicine in Korea: A retrospective large sample cohort study of musculoskeletal disorder patients. Journal of Ethnopharmacology 2015;169:407-12. https://doi.org/10.1016/j.jep.2015.04.048
  12. Xie, C, Wu B, Xi J, Wang R, Zhang C, Li Y, et al. Paeoniflorin ameliorates liver injury of MRL/lpr mice through inhibition of NF-${\kappa}B$ pathway. Chinese journal of cellular and molecular immunology. 2017;33(11):1467-71.
  13. Jameson JL, Kasper DL, Longo DL, Fauci AS, Hauser SL, Loscalzo J. Harrison's Principles of Internal Medicine, 20e. New York: McGraw-Hill Education; 2018.
  14. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmocol Ther 1981;30(2):239-45. https://doi.org/10.1038/clpt.1981.154