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A Case of an Isolated Peripheral Giant Cell Granuloma in the Parotid Gland

이하선에 고립되어 발생한 말초 거대세포 육아종 1예

  • Kim, Soo Jin (Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University, College of Medicine) ;
  • Yun, Ju Hyun (Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University, College of Medicine) ;
  • Park, Sohl (Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University, College of Medicine) ;
  • Kim, Han Su (Department of Otorhinolaryngology-Head and Neck Surgery, Ewha Womans University, College of Medicine)
  • 김수진 (이화여자대학교 의과대학 이비인후-두경부외과학 교실) ;
  • 윤주현 (이화여자대학교 의과대학 이비인후-두경부외과학 교실) ;
  • 박솔 (이화여자대학교 의과대학 이비인후-두경부외과학 교실) ;
  • 김한수 (이화여자대학교 의과대학 이비인후-두경부외과학 교실)
  • Received : 2019.07.24
  • Accepted : 2019.11.07
  • Published : 2019.11.30

Abstract

Peripheral giant cell granuloma (PGCG) is an benign non-neoplastic lesion most commonly occurring in oral cavity but extraoral PGCG is extremely rare. Recently, we experienced a case of an isolated PGCG in the parotid gland in 59-year-old man. FNAB findings and radiologic findings including CT and US were suggestive of Warthin's tumor. Partial parotidectomy was performed. Pathologic findings showed fibrillar connective tissue stroma with spindled, ovoid, and round histiocytes-like cells mixed with uneven multinuclear giant cells, small capillaries, hemorrhage, hemosiderin-laden macrophages, and necrosis which were consistent with giant cell granuloma. We report a case of an PGCG in parotid with a review of literature.

Keywords

References

  1. Henry L. Jaffe, Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol. 1953;6:159-175. https://doi.org/10.1016/0030-4220(53)90151-0
  2. Toru MATSUI, Kohichi IWAMURO, Tosiroh ISHIKAWA, Takao ASANO, Shinji ITOYAMA, Hiroo TABE, Large giant cell reparative granuloma of the petrous bone. Neurologia medico-chirurgica. 2002;42:232-236. https://doi.org/10.2176/nmc.42.232
  3. Xue-Fei Tian, Li TJ, Yu SF. Giant cell granuloma of the temporal bone: A case report with immunohistochemical, enzyme histochemical, and in vitro studies. Arch Pathol Lab Med. 2003;127:1217-1220. https://doi.org/10.5858/2003-127-1217-GCGOTT
  4. Mark D. Murphey, George C. Nomikos, Donald J. Flemming, Francis H. Gannon, H. Thomas Temple, Mark J. Kransdorf, Imaging of giant cell tumor and giant cell reparative granuloma of bone: Radiologic-pathologic correlation. RadioGraphics 2001;21:1283-1309. https://doi.org/10.1148/radiographics.21.5.g01se251283
  5. S. Moghe, M.K. Gupta, A. Pillai, A. Maheswari, Peripheral giant cell granuloma: A case report and review of literature. People's Journal of Scientific Research. 2013;6:55-59.
  6. Ozcan Cengiz, Apaydin FD, Gorur K, Apa DD. Peripheral giant cell granuloma of the mandibular condyle presenting as a preauricular mass. Eur Arch Otorhinolaryngol. 2005;262:178-181. https://doi.org/10.1007/s00405-004-0758-4
  7. Breault LG, Fowler EB, Wolfang MJ, Lewis, DW Peripheral giant cell granuloma: A case report. Gen Dent. 2000;48:716-719.
  8. Junquera LM, Lupi E, Lombardia E, Fresno MF, Multiple and syncronous peripheral giant cell granulomas of the gums. Ann Otol Rhinol Laryngol. 2002;111:751-753. https://doi.org/10.1177/000348940211100817
  9. Mohtasham Nooshin, Saghravanian N, Fatemi B, Vahedi M, Afzal-Aghaee M, Kadeh H, A comparative study of osteopontin and MMP-2 protein expression in peripheral and central giant cell granuloma of the jaw. Braz J Otorhinolaryngol. 2019;85:150-156. https://doi.org/10.1016/j.bjorl.2017.11.006
  10. Morris JM, Lane JI, Witte RJ, et al. Giant cell reparative granuloma of the nasal cavity. Am J Neuroradiol. 2004;25:1263-1265.
  11. Kaustubh P Patil, Ketki P Kalele, Vinayak D Kanakdande, Peripheral giant cell granuloma: A comprehensive review of an ambiguous lesion. Journal of ICDRO. 2014;6:118-125.
  12. Daneshbod yahya, Khademi B, Kadivar M, Ganjei-Azar P, Fine needle aspiration of salivary gland lesions with multinucleated giant cells. Acta Cytol. 2008;52:671-680. https://doi.org/10.1159/000325620
  13. Mario Campanacci. Reparative giant cell granuloma. In: Bone and soft tissue tumors. 2nd ed. Vienna: Springer-Verlag; 1999. p.901-905.
  14. Donath K, Seifert G, Roser K, The spectrum of giant cells in tumours of the salivary glands: an analysis of 11 cases. J Oral Pathol Med. 1997;26:431-436. https://doi.org/10.1111/j.1600-0714.1997.tb00244.x