Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Cutaneous Sterile Pyogranuloma/Granuloma Syndrome in an Old English Bulldog: Case Report

  • Yoon, Ji-Seon (College of Veterinary Medicine, Chonbuk National University) ;
  • Bae, Hyeona (College of Veterinary Medicine, Gyeongsang National University) ;
  • Ahn, Soomin (College of Veterinary Medicine, Gyeongsang National University) ;
  • Hong, Il-Hwa (College of Veterinary Medicine, Gyeongsang National University) ;
  • Jung, Dong-In (College of Veterinary Medicine, Gyeongsang National University) ;
  • Park, Jinho (College of Veterinary Medicine, Chonbuk National University) ;
  • Yu, DoHyeon (College of Veterinary Medicine, Gyeongsang National University)
  • Received : 2019.11.07
  • Accepted : 2019.11.28
  • Published : 2019.12.31
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Abstract

A four-year old, indoor-living neutered male Old English Bulldog was presented for generalized ulcerative dermatitis. Generalized alopecia and multifocal papules and ulcers with crusting were observed mainly in the dorsal trunk. Cytology of the skin lesions revealed a pyogranulomatous inflammation comprising macrophages and nondegenerate neutrophils. Histopathology also revealed a nodular dermatitis characterized by mixed infiltration of monocytes and neutrophils involving the superficial and deep dermis. Neither of bacteria nor fungus was identified in microscopic exam and culture. From those findings, a diagnosis of cutaneous sterile pyogranuloma/granuloma syndrome (SPGS) was made. Treatment with immunosuppressive drugs of prednisone and cyclosporine was performed and visible ulcerative skin lesions were resolved after 4 weeks of initiation of therapy. Treatment with combination of cyclosporine and prednisone may be effective for the case of SPGS.

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References

  1. Cornegliani L, Fondevila D, Vercelli A, Mantero G, Fondati A. PCR technique detection of Leishmania spp. but not Mycobacterium spp. in canine cutaneous 'sterile' pyogranuloma/granuloma syndrome. Vet Dermatol 2005; 16: 233-238. https://doi.org/10.1111/j.1365-3164.2005.00425.x
  2. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Noninfectious nodular and diffuse granulomatous and pyogranulomatous diseases of the dermis. In: Skin diseases of dog and cat: Clinical and histopathologic diagnosis. 2nd ed. Oxford; Blackwell Publishing. 2005; 320-323.
  3. Kawarai S, Matsuura S, Yamamoto S, Kiuchi A, Kanemaki N, Madarame H, Shirota K. A case of cutaneous sterile pyogranuloma/granuloma syndrome in a maltese. J Am Anim Hosp Assoc 2014; 50: 278-283. https://doi.org/10.5326/JAAHA-MS-6009
  4. Kobayashi T, Iwasaki T, Amagai M, Ohyama M. Canine follicle stem cell candidates reside in the bulge and share characteristic features with human bulge cells. J Invest Dermatol 2010; 130: 1988-1995. https://doi.org/10.1038/jid.2010.68
  5. Mercati F, Pascucci L, Gargiulo AM, Dall'Aglio C, Ceccarelli P. Immunohistochemical evaluation of intermediate filament nestin in dog hair follicles. Histol Histopathol 2008; 23: 1035-1041.
  6. Panich R, Scott DW, Miller WH. Canine cutaneous sterile pyogranuloma/granuloma syndrome: A retrospective analysis of 29 cases (1976-1988). J Am Anim Hosp Assoc 1991; 272: 519-528.
  7. Santoro D, Spaterna A, Mechelli L, Ciaramella P. Cutaneous sterile pyogranuloma/granuloma syndrome in a dog. Can Vet J 2008; 49:1204-1207.
  8. Santoro D, Prisco M, Ciaramella P. Cutaneous sterile granulomas/pyogranulomas, leishmaniasis and mycobacterial infections. J Small Anim Pract 2008; 49: 552-561. https://doi.org/10.1111/j.1748-5827.2008.00638.x
  9. Schissler J. Sterile Pyogranulomatous Dermatitis and Panniculitis. Vet Clin North Am Small Anim Pract 2019; 49: 27-36. https://doi.org/10.1016/j.cvsm.2018.08.003