참고문헌
- Querfurth HW and LaFerla FM (2010) Alzheimer's disease. N Engl J Med 362, 329-344 https://doi.org/10.1056/NEJMra0909142
- Cao J, Hou J, Ping J and Cai D (2018) Advances in developing novel therapeutic strategies for Alzheimer's disease. Mol Neurodegener 13, 64 https://doi.org/10.1186/s13024-018-0299-8
- Sanabria-Castro A, Alvarado-Echeverria I and Monge-Bonilla C (2017) Molecular Pathogenesis of Alzheimer's Disease: An Update. Ann Neurosci 24, 46-54 https://doi.org/10.1159/000464422
- Marcus C, Mena E and Subramaniam RM (2014) Brain PET in the diagnosis of Alzheimer's disease. Clin Nucl Med 39, e413-422; quiz e423-416 https://doi.org/10.1097/RLU.0000000000000547
- Mosconi L, Berti V, Glodzik L, Pupi A, De Santi S and de Leon MJ (2010) Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging. J Alzheimers Dis 20, 843-854 https://doi.org/10.3233/JAD-2010-091504
- Patel JR and Brewer GJ (2003) Age-related changes in neuronal glucose uptake in response to glutamate and beta-amyloid. J Neurosci Res 72, 527-536 https://doi.org/10.1002/jnr.10602
- Beal MF (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 38, 357-366 https://doi.org/10.1002/ana.410380304
- Mancuso M, Calsolaro V, Orsucci D et al (2009) Mitochondria, cognitive impairment, and Alzheimer's disease. Int J Alzheimers Dis 2009, 951548
- Zhu X, Perry G, Smith MA and Wang X (2013) Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Alzheimers Dis 33 Suppl 1, S253-262
- Wang X, Su B, Zheng L, Perry G, Smith MA and Zhu X (2009) The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Neurochem 109 Suppl 1, 153-159 https://doi.org/10.1111/j.1471-4159.2009.05867.x
- Swerdlow RH (2018) Mitochondria and Mitochondrial Cascades in Alzheimer's Disease. J Alzheimers Dis 62, 1403-1416 https://doi.org/10.3233/JAD-170585
- Swerdlow RH, Burns JM and Khan SM (2010) The Alzheimer's disease mitochondrial cascade hypothesis. J Alzheimers Dis 20 Suppl 2, S265-279 https://doi.org/10.3233/JAD-2010-100339
- Swerdlow RH, Burns JM and Khan SM (2014) The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives. Biochim Biophys Acta 1842, 1219-1231 https://doi.org/10.1016/j.bbadis.2013.09.010
- Cheng Y and Bai F (2018) The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease. Front Neurosci 12, 163 https://doi.org/10.3389/fnins.2018.00163
- Reddy PH and Beal MF (2008) Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 14, 45-53 https://doi.org/10.1016/j.molmed.2007.12.002
- Szablewski L (2017) Glucose Transporters in Brain: In Health and in Alzheimer's Disease. J Alzheimers Dis 55, 1307-1320 https://doi.org/10.3233/JAD-160841
- Sun J, Feng X, Liang D, Duan Y and Lei H (2012) Down-regulation of energy metabolism in Alzheimer's disease is a protective response of neurons to the microenvironment. J Alzheimers Dis 28, 389-402 https://doi.org/10.3233/JAD-2011-111313
- Sonntag KC, Ryu WI, Amirault KM et al (2017) Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles. Sci Rep 7, 14038 https://doi.org/10.1038/s41598-017-14420-x
- Carvalho C, Cardoso S, Correia SC et al (2012) Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities. Diabetes 61, 1234-1242 https://doi.org/10.2337/db11-1186
- Zhang C, Rissman RA and Feng J (2015) Characterization of ATP alternations in an Alzheimer's disease transgenic mouse model. J Alzheimers Dis 44, 375-378 https://doi.org/10.3233/JAD-141890
- Cha MY, Han SH, Son SM et al (2012) Mitochondriaspecific accumulation of amyloid beta induces mitochondrial dysfunction leading to apoptotic cell death. PLoS One 7, e34929 https://doi.org/10.1371/journal.pone.0034929
- Keeney JT, Ibrahimi S and Zhao L (2015) Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early Intervention. J Alzheimers Dis 48, 411-424 https://doi.org/10.3233/JAD-150348
- Wu L, Zhang X and Zhao L (2018) Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. J Neurosci 38, 6665-6681 https://doi.org/10.1523/JNEUROSCI.2262-17.2018
- Rhein V, Baysang G, Rao S et al (2009) Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells. Cell Mol Neurobiol 29, 1063-1071 https://doi.org/10.1007/s10571-009-9398-y
- Beck SJ, Guo L, Phensy A et al (2016) Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease. Nat Commun 7, 11483 https://doi.org/10.1038/ncomms11483
- David DC, Hauptmann S, Scherping I et al (2005) Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem 280, 23802-23814 https://doi.org/10.1074/jbc.M500356200
- Schulz KL, Eckert A, Rhein V et al (2012) A new link to mitochondrial impairment in tauopathies. Mol Neurobiol 46, 205-216 https://doi.org/10.1007/s12035-012-8308-3
- Rhein V, Song X, Wiesner A et al (2009) Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci U S A 106, 20057-20062 https://doi.org/10.1073/pnas.0905529106
- Manczak M, Anekonda TS, Henson E, Park BS, Quinn J and Reddy PH (2006) Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 15, 1437-1449 https://doi.org/10.1093/hmg/ddl066
- Caspersen C, Wang N, Yao J et al (2005) Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J 19, 2040-2041 https://doi.org/10.1096/fj.05-3735fje
- Devi L, Prabhu BM, Galati DF, Avadhani NG and Anandatheerthavarada HK (2006) Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J Neurosci 26, 9057-9068 https://doi.org/10.1523/JNEUROSCI.1469-06.2006
- Hansson Petersen CA, Alikhani N, Behbahani H et al (2008) The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci U S A 105, 13145-13150 https://doi.org/10.1073/pnas.0806192105
- Chen JX and Yan SS (2010) Role of mitochondrial amyloid-beta in Alzheimer's disease. J Alzheimers Dis 20 Suppl 2, S569-578 https://doi.org/10.3233/JAD-2010-100357
- Han SH, Park JC and Mook-Jung I (2016) Amyloid beta-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets. Prog Neurobiol 137, 17-38 https://doi.org/10.1016/j.pneurobio.2015.12.004
- Yoshida M, Muneyuki E and Hisabori T (2001) ATP synthase--a marvellous rotary engine of the cell. Nat Rev Mol Cell Biol 2, 669-677 https://doi.org/10.1038/35089509
- Cha MY, Cho HJ, Kim C et al (2015) Mitochondrial ATP synthase activity is impaired by suppressed OGlcNAcylation in Alzheimer's disease. Hum Mol Genet 24, 6492-6504 https://doi.org/10.1093/hmg/ddv358
- Halestrap A (2005) Biochemistry: a pore way to die. Nature 434, 578-579 https://doi.org/10.1038/434578a
- Nicotra A and Parvez S (2002) Apoptotic molecules and MPTP-induced cell death. Neurotoxicol Teratol 24, 599-605 https://doi.org/10.1016/S0892-0362(02)00213-1
- Zamzami N, Larochette N and Kroemer G (2005) Mitochondrial permeability transition in apoptosis and necrosis. Cell Death Differ 12 Suppl 2, 1478-1480 https://doi.org/10.1038/sj.cdd.4401682
- Javadov S and Kuznetsov A (2013) Mitochondrial permeability transition and cell death: the role of cyclophilin d. Front Physiol 4, 76
- Du H, Guo L, Fang F et al (2008) Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nat Med 14, 1097-1105 https://doi.org/10.1038/nm.1868
- Lustbader JW, Cirilli M, Lin C et al (2004) ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304, 448-452 https://doi.org/10.1126/science.1091230
- Vogtle FN, Wortelkamp S, Zahedi RP et al (2009) Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell 139, 428-439 https://doi.org/10.1016/j.cell.2009.07.045
- Mossmann D, Vogtle FN, Taskin AA et al (2014) Amyloid-beta peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. Cell Metab 20, 662-669 https://doi.org/10.1016/j.cmet.2014.07.024
- Mishra P and Chan DC (2016) Metabolic regulation of mitochondrial dynamics. J Cell Biol 212, 379-387 https://doi.org/10.1083/jcb.201511036
- Youle RJ and van der Bliek AM (2012) Mitochondrial fission, fusion, and stress. Science 337, 1062-1065 https://doi.org/10.1126/science.1219855
- Zhang L, Trushin S, Christensen TA et al (2016) Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease. Sci Rep 6, 18725 https://doi.org/10.1038/srep18725
- Shah SI, Paine JG, Perez C and Ullah G (2019) Mitochondrial fragmentation and network architecture in degenerative diseases. PLoS One 14, e0223014 https://doi.org/10.1371/journal.pone.0223014
- Wang X, Su B, Lee HG et al (2009) Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci 29, 9090-9103 https://doi.org/10.1523/JNEUROSCI.1357-09.2009
- Tyumentsev MA, Stefanova NA, Kiseleva EV and Kolosova NG (2018) Mitochondria with Morphology Characteristic for Alzheimer's Disease Patients Are Found in the Brain of OXYS Rats. Biochemistry (Mosc) 83, 1083-1088 https://doi.org/10.1134/S0006297918090109
- Trushina E (2016) A shape shifting organelle: unusual mitochondrial phenotype determined with threedimensional electron microscopy reconstruction. Neural Regen Res 11, 900-901
- Xie H, Guan J, Borrelli LA, Xu J, Serrano-Pozo A and Bacskai BJ (2013) Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model. J Neurosci 33, 17042-17051 https://doi.org/10.1523/JNEUROSCI.1836-13.2013
- Perez MJ, Ponce DP, Osorio-Fuentealba C, Behrens MI and Quintanilla RA (2017) Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease. Front Neurosci 11, 553 https://doi.org/10.3389/fnins.2017.00553
- Manczak M, Calkins MJ and Reddy PH (2011) Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Hum Mol Genet 20, 2495-2509 https://doi.org/10.1093/hmg/ddr139
- Joshi AU, Saw NL, Shamloo M and Mochly-Rosen D (2018) Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease. Oncotarget 9, 6128-6143 https://doi.org/10.18632/oncotarget.23640
- Baek SH, Park SJ, Jeong JI et al (2017) Inhibition of Drp1 Ameliorates Synaptic Depression, Abeta Deposition, and Cognitive Impairment in an Alzheimer's Disease Model. J Neurosci 37, 5099-5110 https://doi.org/10.1523/JNEUROSCI.2385-16.2017
- Wang X, Su B, Siedlak SL et al (2008) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A 105, 19318-19323 https://doi.org/10.1073/pnas.0804871105
- Knott AB, Perkins G, Schwarzenbacher R and Bossy-Wetzel E (2008) Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9, 505-518 https://doi.org/10.1038/nrn2417
- Westermann B (2009) Nitric oxide links mitochondrial fission to Alzheimer's disease. Sci Signal 2, pe29
- Cho DH, Nakamura T, Fang J et al (2009) S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324, 102-105 https://doi.org/10.1126/science.1171091
- Kang S, Byun J, Son SM and Mook-Jung I (2018) Thrombospondin-1 protects against Abeta-induced mitochondrial fragmentation and dysfunction in hippocampal cells. Cell Death Discov 4, 31 https://doi.org/10.1038/s41420-017-0023-4
- Manczak M and Reddy PH (2012) Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. Hum Mol Genet 21, 2538-2547 https://doi.org/10.1093/hmg/dds072
- Kandimalla R, Manczak M, Fry D, Suneetha Y, Sesaki H and Reddy PH (2016) Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease. Hum Mol Genet 25, 4881-4897
- Perez MJ, Vergara-Pulgar K, Jara C, Cabezas-Opazo F and Quintanilla RA (2018) Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer's Disease. Mol Neurobiol 55, 1004-1018 https://doi.org/10.1007/s12035-017-0385-x
- Byun J, Son SM, Cha MY et al (2015) CR6-interacting factor 1 is a key regulator in Abeta-induced mitochondrial disruption and pathogenesis of Alzheimer's disease. Cell Death Differ 22, 959-973 https://doi.org/10.1038/cdd.2014.184
- Kim C, Choi H, Jung ES et al (2012) HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons. PLoS One 7, e42983 https://doi.org/10.1371/journal.pone.0042983
- Shahpasand K, Uemura I, Saito T et al (2012) Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease. J Neurosci 32, 2430-2441 https://doi.org/10.1523/JNEUROSCI.5927-11.2012
- Kopeikina KJ, Carlson GA, Pitstick R et al (2011) Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol 179, 2071-2082 https://doi.org/10.1016/j.ajpath.2011.07.004
- Stamer K, Vogel R, Thies E, Mandelkow E and Mandelkow EM (2002) Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 156, 1051-1063 https://doi.org/10.1083/jcb.200108057
- Fecher C, Trovo L, Muller SA et al (2019) Cell-typespecific profiling of brain mitochondria reveals functional and molecular diversity. Nat Neurosci 22, 1731-1742 https://doi.org/10.1038/s41593-019-0479-z
- Ioannou MS, Jackson J, Sheu SH et al (2019) Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity. Cell 177, 1522-1535 e1514 https://doi.org/10.1016/j.cell.2019.04.001
- Park J, Choi H, Min JS et al (2013) Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells. J Neurochem 127, 221-232 https://doi.org/10.1111/jnc.12361
- Orihuela R, McPherson CA and Harry GJ (2016) Microglial M1/M2 polarization and metabolic states. Br J Pharmacol 173, 649-665 https://doi.org/10.1111/bph.13139
- Vos M, Lauwers E and Verstreken P (2010) Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease. Front Synaptic Neurosci 2, 139 https://doi.org/10.3389/fnsyn.2010.00139
- Davey GP, Peuchen S and Clark JB (1998) Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration. J Biol Chem 273, 12753-12757 https://doi.org/10.1074/jbc.273.21.12753
- Brown MR, Sullivan PG and Geddes JW (2006) Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria. J Biol Chem 281, 11658-11668 https://doi.org/10.1074/jbc.M510303200
- Zott B, Simon MM, Hong W et al (2019) A vicious cycle of beta amyloid-dependent neuronal hyperactivation. Science 365, 559-565 https://doi.org/10.1126/science.aay0198
- Du H, Guo L, Yan S, Sosunov AA, McKhann GM and Yan SS (2010) Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A 107, 18670-18675 https://doi.org/10.1073/pnas.1006586107
- Pickett EK, Rose J, McCrory C et al (2018) Regionspecific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease. Acta Neuropathol 136, 747-757 https://doi.org/10.1007/s00401-018-1903-2
- Jadiya P, Kolmetzky DW, Tomar D et al (2019) Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease. Nat Commun 10, 3885 https://doi.org/10.1038/s41467-019-11813-6
- Lee SH, Kim KR, Ryu SY et al (2012) Impaired short-term plasticity in mossy fiber synapses caused by mitochondrial dysfunction of dentate granule cells is the earliest synaptic deficit in a mouse model of Alzheimer's disease. J Neurosci 32, 5953-5963 https://doi.org/10.1523/JNEUROSCI.0465-12.2012
- Lee SH, Lutz D, Mossalam M, Bolshakov VY, Frotscher M and Shen J (2017) Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway. Mol Neurodegener 12, 48 https://doi.org/10.1186/s13024-017-0189-5
- Gazit N, Vertkin I, Shapira I et al (2016) IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses. Neuron 89, 583-597 https://doi.org/10.1016/j.neuron.2015.12.034
- Moloney AM, Griffin RJ, Timmons S, O'Connor R, Ravid R and O'Neill C (2010) Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging 31, 224-243 https://doi.org/10.1016/j.neurobiolaging.2008.04.002
- Zhang B, Tang XC and Zhang HY (2013) Alternations of central insulin-like growth factor-1 sensitivity in APP/PS1 transgenic mice and neuronal models. J Neurosci Res 91, 717-725 https://doi.org/10.1002/jnr.23201
- Allen NJ and Eroglu C (2017) Cell Biology of Astrocyte-Synapse Interactions. Neuron 96, 697-708 https://doi.org/10.1016/j.neuron.2017.09.056
- Rose CF, Verkhratsky A and Parpura V (2013) Astrocyte glutamine synthetase: pivotal in health and disease. Biochem Soc Trans 41, 1518-1524 https://doi.org/10.1042/BST20130237
- Jackson JG, O'Donnell JC, Takano H, Coulter DA and Robinson MB (2014) Neuronal activity and glutamate uptake decrease mitochondrial mobility in astrocytes and position mitochondria near glutamate transporters. J Neurosci 34, 1613-1624 https://doi.org/10.1523/JNEUROSCI.3510-13.2014
- Xu NJ, Bao L, Fan HP et al (2003) Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses. J Neurosci 23, 4775-4784 https://doi.org/10.1523/JNEUROSCI.23-11-04775.2003
- Genda EN, Jackson JG, Sheldon AL et al (2011) Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J Neurosci 31, 18275-18288 https://doi.org/10.1523/JNEUROSCI.3305-11.2011
- Canals S, Larrosa B, Pintor J, Mena MA and Herreras O (2008) Metabolic challenge to glia activates an adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves. J Cereb Blood Flow Metab 28, 1835-1844 https://doi.org/10.1038/jcbfm.2008.71
- Belanger M, Allaman I and Magistretti PJ (2011) Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab 14, 724-738 https://doi.org/10.1016/j.cmet.2011.08.016
- Bouzier-Sore AK and Pellerin L (2013) Unraveling the complex metabolic nature of astrocytes. Front Cell Neurosci 7, 179 https://doi.org/10.3389/fncel.2013.00179
- Fu W, Shi D, Westaway D and Jhamandas JH (2015) Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity. J Biol Chem 290, 12504-12513 https://doi.org/10.1074/jbc.M114.618157
- Ebert D, Haller RG and Walton ME (2003) Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy. J Neurosci 23, 5928-5935 https://doi.org/10.1523/JNEUROSCI.23-13-05928.2003
- Jones VC, Atkinson-Dell R, Verkhratsky A and Mohamet L (2017) Aberrant iPSC-derived human astrocytes in Alzheimer's disease. Cell Death Dis 8, e2696 https://doi.org/10.1038/cddis.2017.89
- Oksanen M, Petersen AJ, Naumenko N et al (2017) PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease. Stem Cell Reports 9, 1885-1897 https://doi.org/10.1016/j.stemcr.2017.10.016
- Sekar S, McDonald J, Cuyugan L et al (2015) Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes. Neurobiol Aging 36, 583-591 https://doi.org/10.1016/j.neurobiolaging.2014.09.027
- Myung NH, Zhu X, Kruman, II et al (2008) Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordr) 30, 209-215 https://doi.org/10.1007/s11357-008-9050-7
- Simpson JE, Ince PG, Haynes LJ et al (2010) Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol Appl Neurobiol 36, 25-40 https://doi.org/10.1111/j.1365-2990.2009.01030.x
- Lee HP, Pancholi N, Esposito L et al (2012) Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. PLoS One 7, e28033 https://doi.org/10.1371/journal.pone.0028033
- Sarkar P, Zaja I, Bienengraeber M et al (2014) Epoxyeicosatrienoic acids pretreatment improves amyloid beta-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes. Am J Physiol Heart Circ Physiol 306, H475-484 https://doi.org/10.1152/ajpheart.00001.2013
- Abeti R, Abramov AY and Duchen MR (2011) Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death. Brain 134, 1658-1672 https://doi.org/10.1093/brain/awr104
- Abramov AY, Canevari L and Duchen MR (2004) Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci 24, 565-575 https://doi.org/10.1523/JNEUROSCI.4042-03.2004
- Culmsee C, Michels S, Scheu S, Arolt V, Dannlowski U and Alferink J (2018) Mitochondria, Microglia, and the Immune System-How Are They Linked in Affective Disorders? Front Psychiatry 9, 739 https://doi.org/10.3389/fphys.2018.00739
- Baik SH, Kang S, Lee W et al (2019) A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease. Cell Metab 30, 493-507 e496 https://doi.org/10.1016/j.cmet.2019.06.005
- Konttinen H, Cabral-da-Silva MEC, Ohtonen S et al (2019) PSEN1DeltaE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia. Stem Cell Reports 13, 669-683 https://doi.org/10.1016/j.stemcr.2019.08.004
- Ulland TK, Song WM, Huang SC et al (2017) TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell 170, 649-663 e613 https://doi.org/10.1016/j.cell.2017.07.023
- Joshi AU, Minhas PS, Liddelow SA et al (2019) Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nat Neurosci 22, 1635-1648 https://doi.org/10.1038/s41593-019-0486-0
- Fang EF, Hou Y, Palikaras K et al (2019) Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nat Neurosci 22, 401-412 https://doi.org/10.1038/s41593-018-0332-9