Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지
DOI QR코드

DOI QR Code

Anti-arthritic Effects of Oplopanax elatus in a Rat Model of Rheumatoid Arthritis (Adjuvant-induced Arthritis)

  • Kwon, Ki Sun (College of Pharmacy, Kangwon National University) ;
  • Lim, Hyun (College of Pharmacy, Kangwon National University) ;
  • Kwon, Yong Soo (College of Pharmacy, Kangwon National University) ;
  • Choi, Hye Ri (College of Pharmacy, Kangwon National University) ;
  • Kim, Myong Jo (Department of Bio-Resource Sciences, Kangwon National University) ;
  • Yoo, Ji Hye (Bioherb Research Institute, Kangwon National University) ;
  • Yoo, Nam Ho (Department of Bio-Resource Sciences, Kangwon National University) ;
  • Kim, Hyun Pyo (College of Pharmacy, Kangwon National University)
  • Received : 2019.05.09
  • Accepted : 2019.09.10
  • Published : 2019.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

The stems of Oplopanax elatus (OE) have long been used to treat inflammatory disorders in herbal medicine, and in the previous investigation, OE was found to possess anti-inflammatory activity in lipopolysaccharide-treated macrophages, RAW 264.7 cell. OE reduces inducible nitric oxide (NO) synthase-induced NO production, and interferes with mitogen-activated protein kinase activation pathways. In the present study, the pharmacological action of the water extract of OE was examined to establish anti-arthritic action, using a rat model of adjuvant-induced arthritis (AIA). The water extract of OE administered orally inhibited AIA-induced arthritis at (100 - 300) mg/kg/day. The paw edema was significantly decreased, in combination with reduced production of pro-inflammatory cytokines. The action mechanism includes an inhibition of MAPKs/nuclear transcription factor-κB activation. These new findings strongly suggest that OE possesses anti-arthritic action, and may be used as a therapeutic agent in inflammation-related disorders, particularly in arthritic condition.

Keywords

References

  1. Crofford, L. J. Arthritis Res. Ther. 2013, 15, S2. https://doi.org/10.1186/ar4174
  2. Ong, C. K.; Lirk, P.; Tan, C. H.; Seymour, R. A. Clin. Med. Res. 2007, 5, 19-34. https://doi.org/10.3121/cmr.2007.698
  3. Kang, S.; Tanaka, T.; Kishimoto, T. Int. Immunol. 2015, 27, 21-29. https://doi.org/10.1093/intimm/dxu081
  4. Kumar, S.; Bhosle, D.; Janghel, A.; Deo, S.; Raut, P.; Verma, C.; Agrawal, M.; Amit, N.; Sharma, M.; Giri, T.; Tripathi, D. K.; Ajaz, A.; Alexander, A. Research J. Pharm. Tech. 2015, 8, 597-610. https://doi.org/10.5958/0974-360X.2015.00099.2
  5. Shikov, A. N.; Pozharitskaya, O. N.; Makarov, V. G.; Yang, W. Z.; Guo, D. A. Chin. J. Nat. Med. 2014, 12, 721-729.
  6. Zhong Hua Ben Cao Commission. Chinese Materia Medica (Zhong Hua Ben Cao); Shanghai Science and Technology Press: China, 1999, pp 5026-5027.
  7. Zhang, S. C.; Wang, K. Z. Acta Pharm. Sin. 1980, 15, 81-85.
  8. Qu, S. Y.; Jiang, X. L.; Wu, Y. J.; Wang, Y. H. Chin. Tradit. Herb. Drugs 1986, 17, 25-26.
  9. Kim, H. K.; Son, K. H.; Chang, H. W.; Kang, S. S.; Kim, H. P. Planta Med. 1999, 65, 465-467. https://doi.org/10.1055/s-2006-960815
  10. Choi, J.; Shin, K. M.; Park, H. J.; Jung, H. J.; Kim, H. J.; Lee, Y. S.; Rew, J. H.; Lee, K. T. Planta Med. 2004, 70, 1027-1032. https://doi.org/10.1055/s-2004-832642
  11. Zhang, A.; Liu, Z.; Sheng, L.; Wu, H. J. Surg. Res. 2017, 209, 252-257. https://doi.org/10.1016/j.jss.2016.10.027
  12. Kwon, K. S.; Lee, J. H.; So, K. S.; Park, B. K.; Lim, H.; Choi, J. S.; Kim, H. P. Phytother. Res. 2018, 32, 1537-1545. https://doi.org/10.1002/ptr.6082
  13. Zhu, T.; Zhang, W.; Feng, S. J.; Yu, H. P. Int. Immunopharmacol. 2016, 34, 16-24. https://doi.org/10.1016/j.intimp.2016.02.014
  14. Yang, M. C.; Kwon, H. C.; Kim, Y. J.; Lee, K. R.; Yang, H. O. J. Nat. Prod. 2010, 73, 801-805. https://doi.org/10.1021/np900628j
  15. Kim, S. Y.; Son, K. H.; Chang, H. W.; Kang, S. S.; Kim, H. P. Arch. Pharm. Res. 1997, 20, 313-317. https://doi.org/10.1007/BF02976192
  16. Bihani, G. V.; Rojatkar, S. R.; Bodhankar, S. L. Biomed. Aging Pathol. 2014, 4, 197-206. https://doi.org/10.1016/j.biomag.2014.04.007
  17. Srivastava, S.; Singh, P.; Jha, K. K.; Mishra, G.; Srivastava, S.; Khosa, R. L. J. Ayurveda Integr. Med. 2012, 3, 204-208. https://doi.org/10.4103/0975-9476.104443