한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제47권4호
  • /
  • Pages.639-644
  • /
  • 2019
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  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Trends in Bacteria Causing Diarrheal Infection from 2010 to 2018 in Cheonan, Korea: Aeromonas spp., Campylobacter spp., and Clostridioides spp.

  • Park, Ji On (Department of Biomedical Laboratory Science, Dankook University College of Health Sciences) ;
  • Kim, Jae Kyung (Department of Biomedical Laboratory Science, Dankook University College of Health Sciences)
  • 투고 : 2019.03.05
  • 심사 : 2019.04.19
  • 발행 : 2019.12.28
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초록

Diarrhea is one of the most common infectious diseases known worldwide. However, few studies have examined anaerobic diarrhea-causing bacteria (DB), which are difficult to culture. Recent advances in molecular biology have facilitated the detection and analysis of anaerobic DB. In this study, long-term trends in anaerobic DB were evaluated in Korea. From 2010 to 2018, symptoms of diarrhea reported were analyzed among patients hospitalized at the Dankook University Hospital in Korea. Results of multiplex polymerase chain reaction based on seasonality, age, overlapping infection, and other factors in patients were evaluated. DB were detected in 38.2% of 1716 stool specimens in the duration of the study. Of the pathogens detected using this method, 49.8% (n = 405/813) were anaerobic bacteria, including Clostridioides perfringens, Campylobacter spp., Clostridioides difficile toxin B, and Aeromonas spp. Among the four anaerobic bacteria, Clostridioides perfringens was the most commonly occurring (15.5%; n = 126/813). Detection rates of Clostridioides perfringens, Clostridioides difficile toxin B, and Aeromonas spp. were 34.1% (n = 22/55), 34.9% (n = 43/126), and 40.0% (n = 38/109), respectively. The detection rate of Campylobacter spp. (32.7%; n = 37/115) was the highest in patients between 10 and 20 years of age. The detection rate of anaerobic DB showed an increase in 2018 as compared with that in 2010, and the number of events of diarrhea caused by anaerobic DB also increased in this duration. Further studies are required to devise methods that might prevent the proliferation of anaerobic DB.

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참고문헌

  1. Foodborne Disease Burden Epidemiology Reference Group. WHO estimates of the global burden of foodborne diseases. World Health Organization, 2015.
  2. Lee S, Park Y, Lee HK, Kim S, Kim J, Lee S. et al. 2013. Detection of 13 enteric bacteria and 5 viruses causing acute infectious diarrhea using multiplex PCR from direct stool specimens. Ann. Clin. Microbiol. 16: 33-38. https://doi.org/10.5145/ACM.2013.16.1.33
  3. Ryu C, Lee M. 2011. Food poisoning. J. Korean Med. Assoc. 54: 617-626. https://doi.org/10.5124/jkma.2011.54.6.617
  4. Centers for Disease Control. Clostridioides perfringens. 2017. Available from: https://www.cdc.gov/foodsafety/diseases/Clostridioides-perfringens.html. Accessed 21 Aug. 2018.
  5. Clarke LE, Diekmann Guiroy B, Mcnamee W, Java DJ Jr, Weiss SM. 1994. Enteritis necroticans with midgut necrosis caused by Clostridioides perfringens. Arch. Surg. 129: 557-560. https://doi.org/10.1001/archsurg.1994.01420290103015
  6. CDC. Campylobacter [Internet]. CDC. Available from: https:// www.cdc.gov/campylobacter/. Accessed 15 April 2019.
  7. Geissler AL, Bustos Carrillo F, Swanson K, Patrick ME, Fullerton KE, Bennett C, et al. 2017. Increasing Campylobacter infections, outbreaks, and antimicrobial resistance in the United States, 2004-2012. Clin. Infect. Dis. 65: 1624-1631. https://doi.org/10.1093/cid/cix624
  8. KCDC. The Prevalence and Characteristics of Bacteria causing Acute Diarrhea in Korea, 2013. Public Health Weekly Report KCDC. 2013 8: 70-74. Available from: www.cdc.go.kr. Accessed 27 Dec. 2018.
  9. Kim N, Cha I, Kim J, Chung GT, Kang Y, Hong S. 2013. The prevalence and characteristics of bacteria causing acute diarrhea in Korea. Kor. J. Clin. Microbiol. 16: 174-181.
  10. Lee K, Kim DS, Chong MS. 2018. Multiplex PCR based epidemiological study for the causes of acute diarrheal disease in adults living in Jeju Island. Ann. Clin. Microbiol. 21: 1-7. https://doi.org/10.5145/ACM.2018.21.1.1
  11. Government of Canada. C-EnterNet. 2018. Available from: https://www.canada.ca/en/public-health/services/surveillance/foodnet-canada.html. Accessed 10 Jan. 2019.
  12. World Health Organization. Campylobacter. 2018. Available from: https://www.who.int/news-room/fact-sheets/detail/campylobacter. Accessed 15 Jan. 2019.
  13. Lee J, Kim J, Cho H, Oh K. 2015. Detection of bacterial and viral pathogens in stool specimens using multiplex PCR. J. Lab. Med. Qual. Assur. 37: 141-147. https://doi.org/10.15263/jlmqa.2015.37.3.141
  14. Acheson D, Allos BM. 2001. Campylobacter jejuni infections: update on emerging issues and trends. Clin. Infect. Dis. 32: 1201-1206. https://doi.org/10.1086/319760
  15. Fan H, Wu Q, Kou X. 2008. Co-detection of five species of waterborne bacteria by multiplex PCR. Life Sci. J. 5: 47-54.
  16. Khamrin P, Okame M, Thongprachum A, Nantachit N, Nishimura S, Okitsu S, et al. 2011. A single-tube multiplex PCR for rapid detection in feces of 10 viruses causing diarrhea. J. Virol. Methods 173: 390-393. https://doi.org/10.1016/j.jviromet.2011.02.012
  17. Lindsay B, Ramamurthy T, Gupta S, Takeda Y, Rajendran K, Nair GB, et al. 2011. Diarrheagenic pathogens in polymicrobial infections. Emerg. Infect. Dis. 17: 606-611. https://doi.org/10.3201/eid1704100939
  18. Bhavnani D, Goldstick JE, Cevallos W, Trueba G, Eisenberg JN. 2012. Synergistic effects between rotavirus and coinfecting pathogens on diarrheal disease: evidence from a communitybased study in northwestern Ecuador. Am. J. Epidemiol. 176: 387-395. https://doi.org/10.1093/aje/kws220
  19. Cho SH, Shin HH, Choi YH, Park MS, Lee BK. 2008. Enteric bacteria isolated from acute diarrheal patients in the Republic of Korea between the year 2004 and 2006. J. Microbiol. 46: 325-330. https://doi.org/10.1007/s12275-008-0015-4
  20. Chitnis AS, Holzbauer SM, Belflower RM, Winston LG, Bamberg WM, Lyons C, et al. 2013. Epidemiology of community-associated Clostridioides difficile infection, 2009 through 2011. JAMA Intern. Med. 173: 1359-1367. https://doi.org/10.1001/jamainternmed.2013.7056
  21. Oh YH, Kim YB. 1988. Use of polymerase chain reaction and serum antibodies for diagnosis of enterohemorrhagic Escherichia coli. J. Korean Soc. Microbiol. 33: 99-110.
  22. Randremanana RV, Randrianirina F, Sabatier P, Rakotonirina HC, Randriamanantena A, Razanajatovo IM, et al. 2014. Campylobacter infection in a cohort of rural children in Moramanga, Madagascar. BMC Infect. Dis. 14: 372. https://doi.org/10.1186/1471-2334-14-372