The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Clinical Research of the Effect of Traditional Herbal Medicine with In Vitro Fertilization and Embryo Transfer in Pubmed

체외 수정과 한약 치료 중재에 대한 임상연구 동향 - Pubmed를 중심으로 -

  • Lee, Mi-Joo (Dept. of Korean Gynecology, CHA Bundang Medical Center, CHA University) ;
  • Son, Sung-Se (Dept. of Acupuncture & Moxibustion, CHA Bundang Medical Center, CHA University) ;
  • Park, Seung-Hyeok (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Park, Kyoung-Sun (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Hwang, Deok-Sang (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Jin-Moo (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Jang, Jun-Bock (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Chang-Hoon (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
  • 이미주 (차의과대학교 분당차병원 한방부인과) ;
  • 손성세 (차의과대학교 분당차병원 침구과) ;
  • 박승혁 (경희대학교 한의과대학 부인과교실) ;
  • 박경선 (경희대학교 한의과대학 부인과교실) ;
  • 황덕상 (경희대학교 한의과대학 부인과교실) ;
  • 이진무 (경희대학교 한의과대학 부인과교실) ;
  • 장준복 (경희대학교 한의과대학 부인과교실) ;
  • 이창훈 (경희대학교 한의과대학 부인과교실)
  • Received : 2018.09.18
  • Accepted : 2018.11.26
  • Published : 2018.11.30
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Abstract

Objectives: The purpose of this systematic review is to assess the effects of herbal medicine with in vitro fertilization-embryo transfer (IVF-ET) based on the current evidence. Methods: Eligible randomized controlled trials (RCT) searched from Pubmed which compared a combination of herbal medicine and IVF with IVF alone were included. Results: Sixteen trials, in which 2025 women involved, were included in this review. The review results showed that the effect of traditional herbal medicine can improve the clinical pregnancy rate (herbal medicine intervention: 30.36~63.64%, Control: 9.38~47.5%) and rate of high quality oocytes and embryos. The mechanism may be through regulating follicular fluid to improve microenvironment for oocytes which would lead to a successful embryo implantation. Conclusions: This analysis showed that combination of IVF and traditional herbal medicine used in the included trials improve clinical pregnancy rate and IVF success. During in vitro fertilization, TCM can regulate the microenvironment in the follicular fluid to mature the oocyte, improve the quality of the embryo, and help the development and implantation of the embryo. Further large randomized placebo controlled trials are needed to confirm the effectiveness of traditional herbal medicine with concurrent IVF.

Keywords

References

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