Nuclear Engineering and Technology

  • 제50권6호
  • /
  • Pages.937-943
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  • 2018
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  • 1738-5733(pISSN)
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  • 2234-358X(eISSN)
한국원자력학회 (Korean Nuclear Society)
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Dosimetric characterization and commissioning of a superficial electronic brachytherapy device for skin cancer treatment

  • Park, Han Beom (Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology) ;
  • Kim, Hyun Nam (Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology) ;
  • Lee, Ju Hyuk (Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology) ;
  • Lee, Ik Jae (Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Choi, Jinhyun (Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Cho, Sung Oh (Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology)
  • 투고 : 2018.01.12
  • 심사 : 2018.04.04
  • 발행 : 2018.08.25
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초록

Background: This work presents the performance of a novel electronic brachytherapy (EBT) device and radiotherapy (RT) experiments on both skin cancer cells and animals using the device. Methods and materials: The performance of the EBT device was evaluated by measuring and analyzing the dosimetric characteristics of X-rays generated from the device. The apoptosis of skin cancer cells was analyzed using B16F10 melanoma cancer cells. Animal experiments were performed using C57BL/6 mice. Results: The X-ray characteristics of the EBT device satisfied the accepted tolerance level for RT. The results of the RT experiments on the skin cancer cells show that a significant apoptosis induction occurred after irradiation with 50 kVp X-rays generated from the EBT device. Furthermore, the results of the animal RT experiments demonstrate that the superficial X-rays significantly delay the tumor growth and that the tumor growth delay induced by irradiation with low-energy X-rays was almost the same as that induced by irradiation with a high-energy electron beam. Conclusions: The developed new EBT device has almost the same therapeutic effect on the skin cancer with a conventional linear accelerator. Consequently, the EBT device can be practically used for human skin cancer treatment in the near future.

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참고문헌

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