Anatomy and Cell Biology

Korean Association of Anatomists (대한해부학회)
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Stem cell transplantation and functional recovery after spinal cord injury: a systematic review and meta-analysis

  • Abbaszadeh, Hojjat-Allah (Hearing Disorders Research Center, Loghman Hakim Medical Center and Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences) ;
  • Niknazar, Somayeh (Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences) ;
  • Darabi, Shahram (Cellular and Molecular Research Center, Qazvin University of Medical Sciences) ;
  • Roozbahany, Navid Ahmady (Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences) ;
  • Noori-Zadeh, Ali (Department of Clinical Biochemistry, Faculty of Paramedicine, Ilam University of Medical Sciences) ;
  • Ghoreishi, Seyed Kamran (Department of Statistics, University of Qom) ;
  • Khoramgah, Maryam Sadat (Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences) ;
  • Sadeghi, Yousef (Hearing Disorders Research Center, Loghman Hakim Medical Center and Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences)
  • Received : 2018.02.21
  • Accepted : 2018.04.13
  • Published : 2018.09.30
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Abstract

Spinal cord injury is a significant cause of motor dysfunctions. There is no definite cure for it, and most of the therapeutic modalities are only symptomatic treatment. In this systematic review and meta-analysis, the effectiveness of stem cell therapy in the treatment of the spinal cord injuries in animal models was studied and evaluated. A systematic search through medical databases by using appropriate keywords was conducted. The relevant reports were reviewed in order to find out cases in which inclusion and exclusion criteria had been fulfilled. Finally, 89 articles have been considered, from which 28 had sufficient data for performing statistical analyses. The findings showed a significant improvement in motor functions after cell therapy. The outcome was strongly related to the number of transplanted cells, site of injury, chronicity of the injury, type of the damage, and the induction of immune-suppression. According to our data, improvements in functional recovery after stem cell therapy in the treatment of spinal cord injury in animal models was noticeable, but its outcome is strongly related to the site of injury, number of transplanted cells, and type of transplanted cells.

Keywords

References

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