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A Cancer Patient Suffering from Chemotherapy-Induced Anorexia and Nausea Treated by Herbal Medicine (Dokhwaljihwang-tang-gamibang) Resulted in Improved Quality of Life: A Case Report

항암치료 후 발생한 식욕부진, 오심에 대하여 독활지황탕 투여 후 삶의 질 개선 증례 보고 1례

  • Kim, Eun-ji (Dept. of Internal Korean Medicine, Dong-Shin Korean Medicine Hospital) ;
  • Kim, Hye-jin (Dept. of Korean Pediatrics, Dong-Shin Korean Medicine Hospital) ;
  • Jang, Seung-won (Dept. of Korean Acupuncture and Moxibustion, Dong-Shin Korean Medicine Hospital) ;
  • Kim, Hyun-ho (Dept. of Korean Acupuncture and Moxibustion, Dong-Shin Korean Medicine Hospital) ;
  • Han, Yang-hee (Dept. of Internal Korean Medicine, Dong-Shin Korean Medicine Hospital) ;
  • Leem, Jung-tae (Dept. of Internal Korean Medicine, Dong-Shin Korean Medicine Hospital)
  • 김은지 (목동동신한방병원 한방내과) ;
  • 김혜진 (목동동신한방병원 한방여성청소년과) ;
  • 장승원 (목동동신한방병원 침구의학과) ;
  • 김현호 (목동동신한방병원 침구의학과) ;
  • 한양희 (목동동신한방병원 한방내과) ;
  • 임정태 (목동동신한방병원 한방내과)
  • Received : 2018.08.03
  • Accepted : 2018.10.27
  • Published : 2018.10.30

Abstract

Despite a considerable improvement in antiemetic chemotherapy and the use of antiemetic prophylaxis for decades, there are still numerous cancer patients suffering from anorexia and nausea after chemotherapy, which forces them to postpone or refuse treatment. This case report is about a 66-year-old female patient diagnosed with malignant lymphoma of the small intestine who underwent right hemicolectomy. After the tumor and the colon adjacent to it were surgically removed, the patient continued to undergo chemotherapy. Chemotherapy-induced anorexia and nausea appeared but were well treated with administration of Dokhwaljihwang-tang-gamibang. During the treatment, no adverse effect related to this Korean medicine was reported. The outcome was evaluated by the functional assessment of anorexia/cachexia therapy (FAACT); the total score increased from 85 to 130 within 12 days, and the symptoms were alleviated. This improvement might suggest the feasibility of Dokhwaljihwang-tang-gamibang to help cancer patients suffering from chemotherapy-induced anorexia and nausea.

Keywords

References

  1. Cho WCS. Acupuncture and Moxibustion as an Evidence-based Therapy for Cancer. Dordrecht: Springer Netherlands: 2012.
  2. Hesketh PJ. Chemotherapy-Induced Nausea and Vomiting. N Engl J Me 2008:358(23):2482-94. https://doi.org/10.1056/NEJMra0706547
  3. Hilarius DL, Kloeg PH, van der Wall E, van den Heuvel JJG, Gundy CM, Aaronson NK. Chemotherapy-induced nausea and vomiting in daily clinical practice:a community hospital-based study. Support Care Cancer 2012:20(1):107-17. https://doi.org/10.1007/s00520-010-1073-9
  4. Grassi L, Berardi MA, Ruffilli F, Meggiolaro E, Andritsch E, Sirgo A, et al. Role of Psychosocial Variables on Chemotherapy-Induced Nausea and Vomiting and Health-Related Quality of Life among Cancer Patients:A European Study. Psychother Psychosom 2015:84(6):339-47. https://doi.org/10.1159/000431256
  5. Dewys WD, Begg C, Lavin PT, Band PR, Bennett JM, Bertino JR, et al. Prognostic effect of weight loss prior tochemotherapy in cancer patients. Am J Med 1980:69(4):491-7. https://doi.org/10.1016/S0149-2918(05)80001-3
  6. Yavuzsen T, Davis MP, Walsh D, LeGrand S, Lagman R. Systematic review of the treatment of cancer-associated anorexia and weight loss. J Clin Oncol Off J Am Soc Clin Oncol 2005:23(33):8500-11. https://doi.org/10.1200/JCO.2005.01.8010
  7. Gilmore J, D'Amato S, Griffith N, Schwartzberg L. Recent advances in antiemetics:new formulations of 5HT3-receptor antagonists. Cancer Manag Res 2018:10:1827-57. https://doi.org/10.2147/CMAR.S166912
  8. Cheng KC, Li YX, Cheng JT. The use of herbal medicine in cancer-related anorexia/ cachexia treatment around the world. Curr Pharm Des 2012:18(31):4819-26. https://doi.org/10.2174/138161212803216979
  9. Genc F, Tan M. The effect of acupressure application on chemotherapy-induced nausea, vomiting, and anxiety in patients with breast cancer. Palliat Support Care 2015;13(02):275-84. https://doi.org/10.1017/S1478951514000248
  10. Huang Z, Qin Z, Yao Q, Wang Y, Liu Z. Moxibustion for Chemotherapy-Induced Nausea and Vomiting:A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med 2017:2017:1-11.
  11. Inoue T, Takagi H, Owada Y, Watanabe Y, Yamaura T, Fukuhara M, et al. The efficacy of the Kampo medicine rikkunshito for chemotherapy-induced anorexia (RICH trial):study protocol for a randomized controlled trial. Trials 2017:18(1):485. https://doi.org/10.1186/s13063-017-2227-6
  12. Morishige K. Traditional herbal medicine, Rikkunshito, for chemotherapy-induced nausea and vomiting. J Gynecol Oncol 2017:28(5):e57. https://doi.org/10.3802/jgo.2017.28.e57
  13. Ohnishi S, Watari H, Kanno M, Ohba Y, Takeuchi S, Miyaji T, et al. Additive effect of rikkunshito, an herbal medicine, on chemotherapy -induced nausea, vomiting, and anorexia in uterine cervical or corpus cancer patients treated with cisplatin and paclitaxel:results of a randomized phase II study (JORTC KMP-02). J Gynecol Oncol 2017:28(5):e44. https://doi.org/10.3802/jgo.2017.28.e44
  14. Cheon C, Park S, Park YL, Huang CW, Ko Y, Jang BH, et al. Sipjeondaebo-tang in patients with cancer with anorexia:a protocol for a pilot, randomised, controlled trial. BMJ Open 2016:6(5):e011212. https://doi.org/10.1136/bmjopen-2016-011212
  15. Yang G, Hu R, Deng A, Huang Y, Li J. Effects of Electro-Acupuncture at Zusanli, Guanyuan for Sepsis Patients and Its Mechanism through Immune Regulation. Chin J Integr Med 2016:22(3):219-24. https://doi.org/10.1007/s11655-016-2462-9
  16. Su YS, Xin JJ, Yang ZK, H We, Shi H, Wang XY, et al. Effects of Different Local Moxibustion-Like Stimuli at Zusanli (ST36) and Zhongwan (CV12) on Gastric Motility and Its Underlying Receptor Mechanism. Evid Based Complement Alternat Med 2015:2015:1-8.
  17. Markowski A, Sanford S, Pikowski J, Fauvell D, Cimino D, Caplan S. A Pilot Study Analyzing the Effects of Chinese Cupping as an Adjunct Treatment for Patients with Subacute Low Back Pain on Relieving Pain, Improving Range of Motion, and Improving Function. J Altern Complement Med 2014:20(2):113-7. https://doi.org/10.1089/acm.2012.0769
  18. Emerich M, Braeunig M, Clement HW, Ludtke R, Huber R. Mode of action of cupping-Local metabolism and pain thresholds in neck pain patients and healthy subjects. Complement Ther Med 2014:22(1):148-58. https://doi.org/10.1016/j.ctim.2013.12.013
  19. LeBlanc TW, Samsa GP, Wolf SP, Locke SC, Cella DF, Abernethy AP. Validation and real-world assessment of the Functional Assessment of Anorexia-Cachexia Therapy (FAACT) scale in patients with advanced non-small cell lung cancer and the cancer anorexia-cachexia syndrome (CACS). Support. Care Cancer 2015:23(8):2341-7. https://doi.org/10.1007/s00520-015-2606-z
  20. Arezzo di Trifiletti A, Misino P, Giannantoni P, Giannantoni B, Cascino A, Fazi L, et al. Comparison of the performance of four different tools in diagnosing disease-associated anorexia and their relationship with nutritional, functional and clinical outcome measures in hospitalized patients. Clin Nutr 2013:32(4):527-32. https://doi.org/10.1016/j.clnu.2012.11.011
  21. Brunelli C, Zecca E, Martini C, Campa T, Fagnoni E, Bagnasco M, et al. Comparison of numerical and verbal rating scales to measure pain exacerbations in patients with chronic cancer pain. Health Qual Life Outcomes 2010:8(1):42. https://doi.org/10.1186/1477-7525-8-42
  22. Jordan K, Gralla R, Jahn F, Molassiotis A. International antiemetic guidelines on chemotherapy induced nausea and vomiting (CINV):Content and implementation in daily routine practice. Eur J Pharmacol 2014:722:197-202. https://doi.org/10.1016/j.ejphar.2013.09.073
  23. Tina Shih YC, Xu Y, Elting LS. Costs of uncontrolled chemotherapy-induced nausea and vomiting among working-age cancer patients receiving highly or moderately emetogenic chemotherapy. Cancer 2007:110(3):678-85. https://doi.org/10.1002/cncr.22823
  24. Burke TA, Wisniewski T, Ernst FR. Resource utilization and costs associated with chemotherapy -induced nausea and vomiting (CINV) following highly or moderately emetogenic chemotherapy administered in the US outpatient hospital setting. Support Care Cancer 2011:19(1):131-40. https://doi.org/10.1007/s00520-009-0797-x
  25. Fearon KC, Voss AC, Hustead DS. Cancer Cachexia Study Group. Definition of cancer cachexia:effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis. Am J Clin Nutr 2006:83(6):1345-50. https://doi.org/10.1093/ajcn/83.6.1345
  26. Mantovani G, Madeddu C, Maccio A, Gramignano G, Lusso MR, Massa E, et al. Cancer-related anorexia/cachexia syndrome and oxidative stress:an innovative approach beyond current treatment. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol 2004:13(10):1651-9.
  27. McClement S. Cancer anorexia-cachexia syndrome:psychological effect on the patient and family. J Wound Ostomy Cont Nurs Off Publ Wound Ostomy Cont Nurses Soc 2005:32(4):264-8. https://doi.org/10.1097/00152192-200507000-00012
  28. Topkan E, Yavuz AA, Ozyilkan O. Cancer cachexia:pathophysiologic aspects and treatment options. Asian Pac J Cancer Prev APJCP 2007:8(3):445-51.
  29. McGuire M. Nutritional care of surgical oncology patients. Semin Oncol Nurs 2000:16(2):128-34. https://doi.org/10.1053/on.2000.5551
  30. Aaltonen LA, Hamilton SR. World Health Organization International Agency for Research on Cancer. Pathology and genetics of tumours of the digestive system. Lyon: Oxford: IARC Press;Oxford University Press (distributor): 2000.
  31. Herrstedt J. Nausea and emesis:still an unsolved problem in cancer patients? Support Care Cancer 2002:10(2):85-7. https://doi.org/10.1007/s00520-001-0339-7
  32. Jang HS, Kim YH, Kim SH, Lee JH, Lee EJ, Song IB, et al. A Case Study of a Somatoform Disorder Patient Diagnosed with Soyangin Symptomatic Pattern of "Yin-Deficiency-Midday -Fever (陰虛午熱證)." J Sasang Const Med 2008:20(2):119-28.
  33. Kim HS, Kim MK, Lee M, Kwon BS, Suh DH, Song YS. Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial. Nutrients 2017:9(7):772. https://doi.org/10.3390/nu9070772
  34. Wang CZ, Yuan CS. Potential Role of Ginseng in the Treatment of Colorectal Cancer. Am J Chin Med 2008:36(6):1019-28. https://doi.org/10.1142/S0192415X08006545
  35. Ma L. Acupuncture as a complementary therapy in chemotherapy-induced nausea and vomiting. Proc Bayl Univ Med Cent 2009:22(2):138-41. https://doi.org/10.1080/08998280.2009.11928494
  36. Jeon JH, Cho CK, Park SJ, Kang HJ, Kim K, Jung IC, et al. A Feasibility Study of Moxibustion for Treating Anorexia and Improving Quality of Life in Patients With Metastatic Cancer: A Randomized Sham-Controlled Trial. Integr Cancer Ther 2017:16(1):118-25. https://doi.org/10.1177/1534735416654762

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