The korean journal of orthodontics (대한치과교정학회지)

The Korean Association Of Orthodontists (대한치과교정학회)
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Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis

  • Nowrin, Shifat A (Orthodontic Unit, School of Dental Sciences, Universiti Sains Malaysia) ;
  • Jaafar, Saidi (Craniofacial Biology Research Group, School of Dental Sciences, Universiti Sains Malaysia) ;
  • Rahman, Norma Ab (Orthodontic Unit, School of Dental Sciences, Universiti Sains Malaysia) ;
  • Basri, Rehana (Department of Medicine, College of Medicine, Al Jouf University) ;
  • Alam, Mohammad Khursheed (Orthodontic Unit, College of Dentistry, Al Jouf University) ;
  • Shahid, Fazal (Orthodontic Unit, School of Dental Sciences, Universiti Sains Malaysia)
  • Received : 2018.03.08
  • Accepted : 2018.07.04
  • Published : 2018.11.01
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Abstract

Objective: To date, only a few studies have investigated the relationships between genetic polymorphisms and external apical root resorption (EARR). Hence, the aim of this systematic review was to explore the relationship between different gene polymorphisms and their association with EARR. Methods: A complete literature search was conducted by two independent reviewers. The PubMed, Science Direct, and Scopus databases were searched. In addition, the bibliographies of all textbooks and relevant articles were searched manually. A meta-analysis was performed using data entered into the electronic databases until February 28, 2017. Results: On the basis of the search, we identified 17 and 7 publications for the systematic review and meta-analysis, respectively. Odds ratio (OR) was used to evaluate the association of the interleukin 1B (+3954) polymorphism and the risk of EARR. The overall OR from the studies was used to estimate the risk of EARR. However, no association was found and no publication bias was apparent for the risk of EARR in patients receiving orthodontic treatment. Conclusions: More research on the relationship between gene polymorphism and EARR is necessary to determine better specificity of possible interactions.

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References

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