Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
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Recent Advances on Resting State Functional Abnormalities of the Default Mode Network in Social Anxiety Disorder

사회불안장애에서 내정상태회로의 휴지기 기능 이상에 관한 최신 지견

  • Yoon, Hyung-Jun (Department of Psychiatry, Chosun University College of Medicine) ;
  • Seo, Eun Hyun (Premedical Science, Chosun University College of Medicine) ;
  • Kim, Seung-Gon (Department of Psychiatry, Chosun University College of Medicine)
  • 윤형준 (조선대학교 의과대학 정신건강의학교실) ;
  • 서은현 (조선대학교 의과대학 의예과) ;
  • 김승곤 (조선대학교 의과대학 정신건강의학교실)
  • Received : 2018.05.25
  • Accepted : 2018.09.28
  • Published : 2018.10.31
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Abstract

It has been suggested that aberrant self-referential processing (SRP) is one of the important components of the explanatory models of social anxiety disorder (SAD). The default mode network (DMN), which reflects intrinsic brain functions, is known to play a critical role in SRP. Recently, resting state functional magnetic resonance imaging (fMRI) research on the functional connectivity in the brain network has gained greater attention as a tool to elucidate the neurobiological basis of various psychiatric disorders. We reviewed resting state fMRI studies that investigated the resting state functional connectivity (RSFC) of the DMN in SAD. Despite of the heterogeneity of the analytic methods and occasional negative findings, most studies consistently reported abnormalities of RSFC within the DMN, suggesting that the DMN may be significant neural correlates of aberrant SRP in SAD. Also, changes in RSFC of the DMN are associated with clinical improvements of therapeutic interventions. Moreover, emerging findings provide the basis for potential use of RSFC as a complementary method in diagnosis of SAD. Ongoing and future research to investigate RSFC of the DMN could broaden our understanding regarding the neurobiological basis of SAD, and contribute to the development of novel treatments for SAD.

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References

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