Brain Tumor Research and Treatment

The Korean Brain Tumor Society (대한뇌종양학회)
권호 표지
DOI QR코드

DOI QR Code

Pheochromocytoma with Brain Metastasis: A Extremely Rare Case in Worldwide

  • Cho, Yun Seong (Department of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine) ;
  • Ryu, Hyang Joo (Department of Pathology, Severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Se Hoon (Department of Pathology, Severance Hospital, Yonsei University College of Medicine) ;
  • Kang, Seok-Gu (Department of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine)
  • Received : 2018.08.10
  • Accepted : 2018.10.05
  • Published : 2018.10.31
⟨ Previous Next ⟩

Abstract

Pheochromocytoma (PCC) is a neuroendocrine tumor that mainly arises from the medulla of the adrenal gland. Some PCCs become malignant and metastasize to other organs. For example, it typically involves skeletal system, liver, lung, and regional lymph nodes. However, only a few cases of PCC with brain metastasis have been reported worldwide. We report a case of metastatic brain tumor from PCC in South Korea in 2016. A 52-year-old man presented with headache, dizziness and motor aphasia. He had a medical history of PCC with multi-organ metastasis, previously underwent several operations, and was treated with chemotherapy and radiotherapy. Brain MRIs showed a brain tumor on the left parietal lobe. Postoperative pathology confirmed that the metastatic brain tumor derived from malignant PCC. This is the first report PCC with brain metastasis in South Korea.

Keywords

Acknowledgement

Supported by : Ministry of Health & Welfare, National Research Foundation of Korea (NRF)

References

  1. Mallory GW, Fang S, Giannini C, Van Gompel JJ, Parney IF. Brain carcinoid metastases: outcomes and prognostic factors. J Neurosurg 2013;118:889-95. https://doi.org/10.3171/2013.1.JNS121556
  2. Hlatky R, Suki D, Sawaya R. Carcinoid metastasis to the brain. Cancer 2004;101:2605-13. https://doi.org/10.1002/cncr.20659
  3. Eisenhofer G, Bornstein SR, Brouwers FM, et al. Malignant pheochromocytoma: current status and initiatives for future progress. Endocr Relat Cancer 2004;11:423-36.
  4. Thouennon E, Elkahloun AG, Guillemot J, et al. Identification of potential gene markers and insights into the pathophysiology of pheochromocytoma malignancy. J Clin Endocrinol Metab 2007;92:4865-72. https://doi.org/10.1210/jc.2007-1253
  5. Ferrari G, Togni R, Pizzedaz C, Aldovini D. Cerebral metastases in pheochromocytoma. Pathologica 1979;71:703-10.
  6. Gentile S, Rainero I, Savi L, Rivoiro C, Pinessi L. Brain metastasis from pheochromocytoma in a patient with multiple endocrine neoplasia type 2A. Panminerva Med 2001;43:305-6.
  7. Melicow MM. One hundred cases of pheochromocytoma (107 tumors) at the Columbia-Presbyterian Medical Center, 1926-1976: a clinicopathological analysis. Cancer 1977;40:1987-2004. https://doi.org/10.1002/1097-0142(197711)40:5<1987::AID-CNCR2820400502>3.0.CO;2-R
  8. Mornex R, Badet C, Peyrin L. Malignant pheochromocytoma: a series of 14 cases observed between 1966 and 1990. J Endocrinol Invest 1992;15:643-9. https://doi.org/10.1007/BF03345808
  9. Gimenez-Roqueplo AP, Favier J, Rustin P, et al. Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. Cancer Res 2003;63:5615-21.
  10. Mannelli M, Lenders JW, Pacak K, Parenti G, Eisenhofer G. Subclinical phaeochromocytoma. Best Pract Res Clin Endocrinol Metab 2012;26:507-15. https://doi.org/10.1016/j.beem.2011.10.008

Cited by

  1. Malignant pheochromocytoma with cerebral and skull metastasis: A case report and literature review vol.9, pp.12, 2021, https://doi.org/10.12998/wjcc.v9.i12.2791