Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
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Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications

  • Uthaman, Saji (Department of Polymer Science and Engineering, Chungnam National University) ;
  • Huh, Kang Moo (Department of Polymer Science and Engineering, Chungnam National University) ;
  • Park, In-Kyu (Department of Biomedical Sciences, BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School)
  • Received : 2018.06.16
  • Accepted : 2018.08.02
  • Published : 2018.09.30
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Abstract

Background: Cancer is one of the deadliest threats to human health. Abnormal physiochemical conditions and dysregulated biosynthetic intermediates in the tumor microenvironment (TME) play a significant role in modulating cancer cells to evade or defend conventional anti-cancer therapy such as surgery, chemotherapy and radiotherapy. One of the most important challenges in the development of anti-tumor therapy is the successful delivery of therapeutic and imaging agents specifically to solid tumors. Main body: The recent progresses in development of TME responsive nanoparticles offers promising strategies for combating cancer by making use of the common attributes of tumor such as acidic and hypoxic microenvironments. In this review, we discussed the prominent strategies utilized in the development of tumor microenvironment-responsive nanoparticles and mode of release of therapeutic cargo. Conclusion: Tumor microenvironment-responsive nanoparticles offers a universal approach for anti-cancer therapy.

Keywords

Acknowledgement

Grant : Externally Actuatable Nanorobot System for Precise Targeting and Controlled Releasing of Drugs

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