Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Cone-Beam CT Virtual Navigation-Guided Percutaneous Needle Biopsy of Suspicious Pleural Metastasis: A Pilot Study

  • Lim, Hyun-ju (Department of Radiology, Seoul National University Hospital) ;
  • Park, Chang Min (Department of Radiology, Seoul National University Hospital) ;
  • Yoon, Soon Ho (Department of Radiology, Seoul National University Hospital) ;
  • Bae, Jae Seok (Department of Radiology, Seoul National University Hospital) ;
  • Goo, Jin Mo (Department of Radiology, Seoul National University Hospital)
  • Received : 2017.11.10
  • Accepted : 2018.02.06
  • Published : 2018.10.01
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Abstract

Objective: To evaluate the diagnostic performance of cone-beam computed tomography (CBCT) virtual navigation-guided percutaneous pleural biopsy for suspected malignant pleural disease. Materials and Methods: This study enrolled 59 patients (31 males and 28 females; mean age, 63.4 years) with suspected malignant pleural disease diagnosed with CBCT from December 2010 to December 2016. Sixty-three CBCT-guided biopsies were performed using a coaxial system with 18- or 20-gauge cutting needles. Procedural details, diagnostic performance, radiation exposure, and complication rates were investigated. Results: The mean diameter perpendicular to the pleura of 51 focal and 12 diffuse pleural lesions was $1.53{\pm}0.76 cm$. The mean distance from the skin to the target was $3.40{\pm}1.51cm$. Mean numbers of CT acquisitions and biopsies were $3.21{\pm}0.57$ and $3.05{\pm}1.54$. Total procedure time and coaxial introducer indwelling time were $11.87{\pm}5.59min$ and $8.78{\pm}4.95min$, respectively. The mean dose area product was $12013.61{\pm}7969.59mGym^2$. There were 48 malignant, 10 benign, and 5 indeterminate lesions. Sensitivity, specificity, and diagnostic accuracy were 93.8% (45/48), 100% (10/10), and 94.8% (55/58), respectively. Positive and negative predictive values for malignancy were 100% (45/45) and 76.9% (10/13), respectively. Four patients (6.8%) with benign pathology during initial biopsy but still showing a high suspicion of malignancy underwent repeat biopsy and three of them were finally diagnosed with malignant pleural disease. There were three cases of minimal pneumothorax and no grave procedure-related complications. Conclusion: Cone-beam computed tomography-guided biopsy is an accurate and safe diagnostic technique for suspected malignant pleural lesion with reasonable radiation exposure and procedure time.

Keywords

Acknowledgement

Supported by : Korea Health Industry Development Institute (KHIDI)

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