Research in Vestibular Science

The Korean Balance Society (대한평형의학회)
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Identification of Vestibular Organ Originated Information on Spatial Memory in Mice

마우스 공간지각과 기억 형성에 미치는 전정 유래 정보의 규명

  • Han, Gyu Cheol (Department of Otolaryngology-Head and Neck Surgery, Gachon University of Medicine and Science, Graduate School of Medicine) ;
  • Kim, Minbum (Department of Otorhinolaryngology-Head and Neck Surgery, Catholic Kwandong University, International St. Mary's Hospital) ;
  • Kim, Mi Joo (Department of Otorhinolaryngology-Head and Neck Surgery, Catholic Kwandong University, International St. Mary's Hospital)
  • 한규철 (가천대학교 길병원 이비인후과) ;
  • 김민범 (가톨릭관동대학교 의과대학 이비인후과학교실) ;
  • 김미주 (가톨릭관동대학교 의과대학 이비인후과학교실)
  • Received : 2018.11.05
  • Accepted : 2018.12.02
  • Published : 2018.12.15
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Abstract

Objectives: We aimed to study the role of vestibular input on spatial memory performance in mice that had undergone bilateral surgical labyrinthectomy, semicircular canal (SCC) occlusion and 4G hypergravity exposure. Methods: Twelve to 16 weeks old ICR mice (n=30) were used for the experiment. The experimental group divided into 3 groups. One group had undergone bilateral chemical labyrinthectomy, and the other group had performed SCC occlusion surgery, and the last group was exposed to 4G hypergravity for 2 weeks. The movement of mice was recorded using camera in Y maze which had 3 radial arms (35 cm long, 7 cm high, 10 cm wide). We counted the number of visiting arms and analyzed the information of arm selection using program we developed before and after procedure. Results: The bilateral labyrinthectomy group which semicircular canal and otolithic function was impaired showed low behavioral performance and spacial memory. The semicircular canal occlusion with $CO_2$ laser group which only semicircular canal function was impaired showed no difference in performance activity and spatial memory. However the hypergravity exposure group in which only otolithic function impaired showed spatial memory function was affected but the behavioral performance was spared. The impairment of spatial memory recovered after a few days after exposure in hypergravity group. Conclusions: This spatial memory function was affected by bilateral vestibular loss. Space-related information processing seems to be determined by otolithic organ information rather than semicircular canals. Due to otolithic function impairment, spatial learning was impaired after exposure to gravity changes in animals and this impaired performance was compensated after normal gravity exposure.

Keywords

Acknowledgement

Supported by : 한국연구재단

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  1. The Differential Effects of Acute Right- vs. Left-Sided Vestibular Deafferentation on Spatial Cognition in Unilateral Labyrinthectomized Mice vol.12, pp.None, 2018, https://doi.org/10.3389/fneur.2021.789487