Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibitory Effect of Sparassis crispa (Wulf.) Extract on Monosodium Iodoacetate Induced Osteoarthritis

꽃송이버섯 추출물의 Monosodium Iodoacetate로 유도된 골관절염 억제 효과

  • 김은남 (계명대학교 약학대학) ;
  • 노성수 (대구한의대학교 한의과대학) ;
  • 정길생 (계명대학교 약학대학)
  • Received : 2018.09.07
  • Accepted : 2018.09.21
  • Published : 2018.09.30
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Abstract

Sparassis crispa (Wulf.) is an edible/medicinal mushroom and has been reported to biological activities such as antitumor, anti-angiogenesis, antioxidant and wound healing. However, there have not been many researches on osteoarthritis of S. crispa. The aim of this study was to investigate the effects of S. crispa extract on rats with osteoarthritis induced by MIA. Osteoarthritis is a gradually developmental disease that early stage, causes joint stiffness and complains of joint pain. In addition, it gives rise to edema and hypo-function. The results of this study, S. crispa extract effectively inhibited ROS production, increased the production of antioxidant protein SOD and catalase in knee joint cartilage tissue. In addition, S. crispa extract inhibited the expression of pro-inflammatory cytokines and enzymes such as NOX4 and $P47^{phox}$, which are involved in the expression of COX-2, iNOS and the production of ROS. Also, S. crispa extract inhibited the destruction of synovial tissue, cartilage tissue and proteoglycans in articular cartilage in rats.

Keywords

References

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